All Outputs (11)

Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age-related anabolic resistance to exercise in humans (2016)
Journal Article

Ageing is associated with impaired hypertrophic responses to resistance exercise training (RET). Here we investigated the aetiology of ‘anabolic resistance’ in older humans. Twenty healthy male individuals, 10 younger (Y; 23 ± 1 years) and 10 older (... Read More about Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age-related anabolic resistance to exercise in humans.

Stable isotope tracers and exercise physiology: past, present and future (2016)
Journal Article

Supplementing essential amino acids with the nitric oxide precursor, l-arginine, enhances skeletal muscle perfusion without impacting anabolism in older men (2016)
Journal Article

Postprandial limb blood flow and skeletal muscle microvascular perfusion reduce with aging. Here we tested the impact of providing bolus essential amino acids (EAA) in the presence and absence of the nitric oxide precursor, l-Arginine (ARG), upon ske... Read More about Supplementing essential amino acids with the nitric oxide precursor, l-arginine, enhances skeletal muscle perfusion without impacting anabolism in older men.

Human Skeletal Muscle Disuse Atrophy: Effects on Muscle Protein Synthesis, Breakdown, and Insulin Resistance—A Qualitative Review (2016)
Journal Article

The ever increasing burden of an ageing population and pandemic of metabolic syndrome worldwide demands further understanding of the modifiable risk factors in reducing disability and morbidity associated with these conditions. Disuse skeletal muscle... Read More about Human Skeletal Muscle Disuse Atrophy: Effects on Muscle Protein Synthesis, Breakdown, and Insulin Resistance—A Qualitative Review.

Metformin Increases Cortisol Regeneration by 11?HSD1 in Obese Men With and Without Type 2 Diabetes Mellitus (2016)
Journal Article

CONTEXT: The mechanism of action of metformin remains unclear. Given the regulation of the cortisol-regenerating enzyme 11?hydroxysteroid dehydrogenase 1 (11?HSD1) by insulin and the limited efficacy of selective 11?HSD1 inhibitors to lower blood gl... Read More about Metformin Increases Cortisol Regeneration by 11?HSD1 in Obese Men With and Without Type 2 Diabetes Mellitus.

Human Skeletal Muscle Protein Metabolism Responses to Amino Acid Nutrition (2016)
Journal Article

Healthy individuals maintain remarkably constant skeletal muscle mass across much of adult life, suggesting the existence of robust homeostatic mechanisms. Muscle exists in dynamic equilibrium whereby the influx of amino acids (AAs) and the resulting... Read More about Human Skeletal Muscle Protein Metabolism Responses to Amino Acid Nutrition.

Mitochondrial function and dynamics imaged in vivo (2016)
Book Chapter

The previous chapters have described the extraordinary depth of knowledge of mitochondrial biology revealed by in vitro observations where the environment can be closely controlled. However, in recent years there has been increased interest in the st... Read More about Mitochondrial function and dynamics imaged in vivo.

An overview of technical considerations for Western blotting applications to physiological research (2016)
Journal Article

The applications of Western/immuno-blotting (WB) techniques have reached multiple layers of the scientific community and are now considered routine procedures in the field of physiology. This is none more so than in relation to skeletal muscle physio... Read More about An overview of technical considerations for Western blotting applications to physiological research.

Enriching a protein drink with leucine augments muscle protein synthesis after resistance exercise in young and older men (2016)
Journal Article

© 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism Maximizing anabolic responses to feeding and exercise is crucial for muscle maintenance and adaptation to exercise training. We hypothesized that enriching a protein drink... Read More about Enriching a protein drink with leucine augments muscle protein synthesis after resistance exercise in young and older men.

Acute cocoa flavanol supplementation improves muscle macro- and microvascular but not anabolic responses to amino acids in older men (2016)
Journal Article

The anabolic effects of nutrition on skeletal muscle may depend on adequate skeletal muscle perfusion, which is impaired in older people. Cocoa flavanols have been shown to improve flow-mediated dilation, an established measure of endothelial functio... Read More about Acute cocoa flavanol supplementation improves muscle macro- and microvascular but not anabolic responses to amino acids in older men.

Relative Contribution of Intramyocellular Lipid to Whole-Body Fat Oxidation Is Reduced With Age but Subsarcolemmal Lipid Accumulation and Insulin Resistance Are Only Associated With Overweight Individuals (2016)
Journal Article

© 2016 by the American Diabetes Association. Insulin resistance is closely related to intramyocellular lipid (IMCL) accumulation, and both are associated with increasing age. It remains to be determined to what extent perturbations in IMCL metabolism... Read More about Relative Contribution of Intramyocellular Lipid to Whole-Body Fat Oxidation Is Reduced With Age but Subsarcolemmal Lipid Accumulation and Insulin Resistance Are Only Associated With Overweight Individuals.