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Neurovascular coupling methods in healthy individuals using transcranial doppler ultrasonography: A systematic review and consensus agreement (2024)
Journal Article
Ball, J. D., Hills, E., Altaf, A., Ramesh, P., Green, M., Surti, F. B., Minhas, J. S., Robinson, T. G., Bond, B., Lester, A., Hoiland, R., Klein, T., Liu, J., Nasr, N., Junejo, R. T., Müller, M., Lecchini-Visintini, A., Mitsis, G., Burma, J. S., Smirl, J. D., …Beishon, L. . C. (2024). Neurovascular coupling methods in healthy individuals using transcranial doppler ultrasonography: A systematic review and consensus agreement. Journal of Cerebral Blood Flow and Metabolism, https://doi.org/10.1177/0271678x241270452

Neurovascular coupling (NVC) is the perturbation of cerebral blood flow (CBF) to meet varying metabolic demands induced by various levels of neural activity. NVC may be assessed by Transcranial Doppler ultrasonography (TCD), using task activation pro... Read More about Neurovascular coupling methods in healthy individuals using transcranial doppler ultrasonography: A systematic review and consensus agreement.

Simultaneous whole-head electrophysiological recordings using EEG and OPM-MEG (2024)
Journal Article
Seedat, Z. A., Pier, K. S., Holmes, N., Rea, M., Al-Hilaly, L., Tierney, T. M., …Brookes, M. J. (2024). Simultaneous whole-head electrophysiological recordings using EEG and OPM-MEG. Imaging Neuroscience, 2, 1-15. https://doi.org/10.1162/imag_a_00179

Electroencephalography (EEG) and magnetoencephalography (MEG) non-invasively measure human brain electrophysiology. They differ in nature; MEG offers better performance whilst EEG (a wearable platform) is more practical. They are also complementary,... Read More about Simultaneous whole-head electrophysiological recordings using EEG and OPM-MEG.

Post‐task responses following working memory and movement are driven by transient spectral bursts with similar characteristics (2024)
Journal Article
Coleman, S. C., Seedat, Z. A., Pakenham, D. O., Quinn, A. J., Brookes, M. J., Woolrich, M. W., & Mullinger, K. J. (2024). Post‐task responses following working memory and movement are driven by transient spectral bursts with similar characteristics. Human Brain Mapping, 45(7), Article e26700. https://doi.org/10.1002/hbm.26700

The post-movement beta rebound has been studied extensively using magnetoencephalography (MEG) and is reliably modulated by various task parameters as well as illness. Our recent study showed that rebounds, which we generalise as “post-task responses... Read More about Post‐task responses following working memory and movement are driven by transient spectral bursts with similar characteristics.

Measurement of Frontal Midline Theta Oscillations using OPM-MEG (2023)
Journal Article
Rhodes, N., Rea, M., Boto, E., Rier, L., Shah, V., Hill, R. M., …Brookes, M. J. (2023). Measurement of Frontal Midline Theta Oscillations using OPM-MEG. NeuroImage, 271, Article 120024. https://doi.org/10.1016/j.neuroimage.2023.120024

Optically pumped magnetometers (OPMs) are an emerging lightweight and compact sensor that can measure magnetic fields generated by the human brain. OPMs enable construction of wearable magnetoencephalography (MEG) systems, which offer advantages over... Read More about Measurement of Frontal Midline Theta Oscillations using OPM-MEG.

Across the adult lifespan the ipsilateral sensorimotor cortex negative BOLD response exhibits decreases in magnitude and spatial extent suggesting declining inhibitory control (2022)
Journal Article
Mayhew, S. D., Coleman, S. C., & Mullinger, K. J. (2022). Across the adult lifespan the ipsilateral sensorimotor cortex negative BOLD response exhibits decreases in magnitude and spatial extent suggesting declining inhibitory control. NeuroImage, 253, Article 119081. https://doi.org/10.1016/j.neuroimage.2022.119081

Ipsilateral sensorimotor (iSM1) cortex negative BOLD responses (NBR) are observed to unilateral tasks and are thought to reflect a functionally relevant component of sensorimotor inhibition. Evidence suggests that sensorimotor inhibitory mechanisms d... Read More about Across the adult lifespan the ipsilateral sensorimotor cortex negative BOLD response exhibits decreases in magnitude and spatial extent suggesting declining inhibitory control.

Imaging Cerebral Blood Flow for Brain Health Measurement (2021)
Book Chapter
Burley, C. V., Mullinger, K. J., Thomas, K. N., Rendeiro, C., Dehghani, H., & Lucas, S. J. (2021). Imaging Cerebral Blood Flow for Brain Health Measurement. In Reference Module in Neuroscience and Biobehavioral Psychology (126-135). Elsevier. https://doi.org/10.1016/b978-0-12-819641-0.00157-2

Cerebral blood flow (CBF) measures are used in clinical settings to diagnose conditions (e.g., vasospasms, sickle cell disease, stroke, dementia, confirmation of brain death), as well as in research, emerging as potential early biomarkers of declinin... Read More about Imaging Cerebral Blood Flow for Brain Health Measurement.

Measuring resting cerebral haemodynamics using MRI arterial spin labelling and transcranial Doppler ultrasound: comparison in younger and older adults (2021)
Journal Article
Burley, C. V., Francis, S. T., Whittaker, A. C., Mullinger, K. J., & Lucas, S. J. E. (2021). Measuring resting cerebral haemodynamics using MRI arterial spin labelling and transcranial Doppler ultrasound: comparison in younger and older adults. Brain and Behavior, 11(7), Article e02126. https://doi.org/10.1002/brb3.2126

Introduction: Resting cerebral blood flow (CBF) and perfusion measures have been used to determine brain health. Studies showing variation in resting CBF with age and fitness level using different imaging approaches have produced mixed findings. We a... Read More about Measuring resting cerebral haemodynamics using MRI arterial spin labelling and transcranial Doppler ultrasound: comparison in younger and older adults.

Contrasting Measures of Cerebrovascular Reactivity Between MRI and Doppler: A Cross-Sectional Study of Younger and Older Healthy Individuals (2021)
Journal Article
Burley, C. V., Francis, S. T., Thomas, K. N., Whittaker, A. C., Lucas, S. J., & Mullinger, K. J. (2021). Contrasting Measures of Cerebrovascular Reactivity Between MRI and Doppler: A Cross-Sectional Study of Younger and Older Healthy Individuals. Frontiers in Physiology, 12, Article 656746. https://doi.org/10.3389/fphys.2021.656746

Cerebrovascular reactivity (CVR) is used as an outcome measure of brain health. Traditionally, lower CVR is associated with ageing, poor fitness and brain-related conditions (e.g. stroke, dementia). Indeed, CVR is suggested as a biomarker for disease... Read More about Contrasting Measures of Cerebrovascular Reactivity Between MRI and Doppler: A Cross-Sectional Study of Younger and Older Healthy Individuals.

The CO2‐stimulus duration and steady‐state time‐point used for data extraction alters the cerebrovascular reactivity outcome measure (2020)
Journal Article
Burley, C. V., Lucas, R. A., Whittaker, A. C., Mullinger, K., & Lucas, S. J. (2020). The CO2‐stimulus duration and steady‐state time‐point used for data extraction alters the cerebrovascular reactivity outcome measure. Experimental Physiology, 105(5), 893-903. https://doi.org/10.1113/ep087883

Cerebrovascular reactivity to carbon dioxide (CVR) is a common functional test to assess brain vascular health, though conflicting age and fitness effects have been reported. Studies have used different CO2 -stimulus durations to induce CVR and extra... Read More about The CO2‐stimulus duration and steady‐state time‐point used for data extraction alters the cerebrovascular reactivity outcome measure.

Alpha/beta power decreases track the fidelity of stimulus-specific information (2019)
Journal Article
Griffiths, B. J., Mayhew, S. D., Mullinger, K. J., Jorge, J., Charest, I., Wimber, M., & Hanslmayr, S. (2019). Alpha/beta power decreases track the fidelity of stimulus-specific information. eLife, 8, Article e49562. https://doi.org/10.7554/elife.49562

© 2019, Griffiths et al. Massed synchronised neuronal firing is detrimental to information processing. When networks of task-irrelevant neurons fire in unison, they mask the signal generated by task-critical neurons. On a macroscopic level, such sync... Read More about Alpha/beta power decreases track the fidelity of stimulus-specific information.

Post-stimulus beta responses are modulated by task duration (2019)
Journal Article
Pakenham, D. O., Quinn, A. J., Fry, A., Francis, S. T., Woolrich, M. W., Brookes, M. J., & Mullinger, K. J. (2020). Post-stimulus beta responses are modulated by task duration. NeuroImage, 206, Article 116288. https://doi.org/10.1016/j.neuroimage.2019.116288

Modulation of beta-band neural oscillations during and following movement is a robust marker of brain function. In particular, the post-movement beta rebound (PMBR), which occurs on movement cessation, has been related to inhibition and connectivity... Read More about Post-stimulus beta responses are modulated by task duration.

The relationship between negative BOLD responses and ERS and ERD of alpha/beta oscillations in visual and motor cortex (2019)
Journal Article
Wilson, R., Mullinger, K. J., Francis, S. T., & Mayhew, S. D. (2019). The relationship between negative BOLD responses and ERS and ERD of alpha/beta oscillations in visual and motor cortex. NeuroImage, 199, 635-650. https://doi.org/10.1016/j.neuroimage.2019.06.009

Previous work has investigated the electrophysiological origins of the intra-modal (within the stimulated sensory cortex) negative BOLD fMRI response (NBR, decrease from baseline) but little attention has been paid to the origin of cross-modal NBRs,... Read More about The relationship between negative BOLD responses and ERS and ERD of alpha/beta oscillations in visual and motor cortex.

Addressing challenges of high spatial resolution, UHF field fMRI for group analysis of higher-order cognitive tasks; an inter-sensory task directing attention between visual and somatosensory domains (2018)
Other
Aquino, K. M., Sokoliuk, R., Pakenham, D., Sanchez, R., Hanslmayr, S., Mayhew, S., …Francis, S. (2019). Addressing challenges of high spatial resolution, UHF field fMRI for group analysis of higher-order cognitive tasks; an inter-sensory task directing attention between visual and somatosensory domains

Moving magnetoencephalography towards real-world applications with a wearable system (2018)
Journal Article
Boto, E., Holmes, N., Leggett, J., Roberts, G., Shah, V., Meyer, S. S., …Brookes, M. J. (2018). Moving magnetoencephalography towards real-world applications with a wearable system. Nature, 555, 657-661. https://doi.org/10.1038/nature26147

Imaging human brain function with techniques such as magnetoencephalography1 (MEG) typically requires a subject to perform tasks whilst their head remains still within a restrictive scanner. This artificial environment makes the technique inaccessibl... Read More about Moving magnetoencephalography towards real-world applications with a wearable system.

Exploring the advantages of multiband fMRI with simultaneous EEG to investigate coupling between gamma frequency neural activity and the BOLD response in humans (2018)
Journal Article
Uji, M., Wilson, R., Francis, S. T., Mullinger, K. J., & Mayhew, S. D. (2018). Exploring the advantages of multiband fMRI with simultaneous EEG to investigate coupling between gamma frequency neural activity and the BOLD response in humans. Human Brain Mapping, 39(4), 1673-1687. https://doi.org/10.1002/hbm.23943

We established an optimal combination of EEG recording during sparse multiband (MB) fMRI that preserves high resolution, whole brain fMRI coverage whilst enabling broad-band EEG recordings which are uncorrupted by MRI gradient artefacts (GAs). We fir... Read More about Exploring the advantages of multiband fMRI with simultaneous EEG to investigate coupling between gamma frequency neural activity and the BOLD response in humans.

Decoding fMRI events in sensorimotor motor network using sparse paradigm free mapping and activation likelihood estimates: Decoding fMRI Events in SMN (2017)
Journal Article
Tan, F. M., Caballero-Gaudes, C., Mullinger, K. J., Cho, S.-Y., Zhang, Y., Dryden, I. L., …Gowland, P. A. (2017). Decoding fMRI events in sensorimotor motor network using sparse paradigm free mapping and activation likelihood estimates: Decoding fMRI Events in SMN. Human Brain Mapping, 38(11), 5778-5794. https://doi.org/10.1002/hbm.23767

Most functional MRI (fMRI) studies map task-driven brain activity using a block or event-related paradigm. Sparse paradigm free mapping (SPFM) can detect the onset and spatial distribution of BOLD events in the brain without prior timing information,... Read More about Decoding fMRI events in sensorimotor motor network using sparse paradigm free mapping and activation likelihood estimates: Decoding fMRI Events in SMN.