All Outputs (65)

Theoretical approaches to understanding root vascular patterning: a consensus between recent models (2016)
Journal Article

The root vascular tissues provide an excellent system for studying organ patterning, as the specification of these tissues signals a transition from radial symmetry to bisymmetric patterns. The patterning process is controlled by the combined action... Read More about Theoretical approaches to understanding root vascular patterning: a consensus between recent models.

Biphasic regulation of the transcription factor ABORTED MICROSPORES (AMS) is essential for tapetum and pollen development in Arabidopsis (2016)
Journal Article

Viable pollen is essential for plant reproduction and crop yield. Its production requires coordinated expression at specific stages during anther development, involving early meiosis-associated events and late pollen wall formation. The ABORTED MICRO... Read More about Biphasic regulation of the transcription factor ABORTED MICROSPORES (AMS) is essential for tapetum and pollen development in Arabidopsis.

Hybrid vertex-midline modelling of elongated plant organs (2016)
Journal Article

We describe a method for the simulation of the growth of elongated plant organs, such as seedling roots. By combining a midline representation of the organ on a tissue scale and a vertex-based representation on the cell scale, we obtain a multiscale... Read More about Hybrid vertex-midline modelling of elongated plant organs.

Dynamic regulation of auxin oxidase and conjugating enzymes AtDAO1 and GH3 modulates auxin homeostasis (2016)
Journal Article

Auxin is a key hormone regulating plant growth and development. We combine experiments and mathematical modeling to reveal how auxin levels are maintained via feedback regulation of genes encoding key metabolic enzymes. We describe how regulation of... Read More about Dynamic regulation of auxin oxidase and conjugating enzymes AtDAO1 and GH3 modulates auxin homeostasis.

The effects of insulin resistance on individual tissues: an application of a mathematical model of metabolism in humans (2016)
Journal Article

Whilst the human body expends energy constantly, the human diet consists of a mix of carbohydrates and fats delivered in a discontinuous manner. To deal with this sporadic supply of energy, there are transport, storage and utilisation mechanisms, for... Read More about The effects of insulin resistance on individual tissues: an application of a mathematical model of metabolism in humans.

A multi-scale model of the interplay between cell signalling and hormone transport in specifying the root meristem of Arabidopsis thaliana (2016)
Journal Article

The growth of the root of Arabidopsis thaliana is sustained by the meristem, a region of cell proliferation and differentiation which is located in the root apex and generates cells which move shootwards, expanding rapidly to cause root growth. The b... Read More about A multi-scale model of the interplay between cell signalling and hormone transport in specifying the root meristem of Arabidopsis thaliana.

Multicellular mathematical modelling of mesendoderm formation in amphibians (2016)
Journal Article

The earliest cell fate decisions in a developing embryo are those associated with establishing the germ layers. The specification of the mesoderm and endoderm is of particular interest as the mesoderm is induced from the endoderm, potentially from an... Read More about Multicellular mathematical modelling of mesendoderm formation in amphibians.

Asymptotic analysis of a doubly nonlinear diffusion equation (2015)
Journal Article

We investigate the doubly nonlinear diffusion equation ?u/?t=1/n ?.(u^m??u?^n-1) ?u) and the same equation expressed in terms of a `pressure' variable. We classify various classes of compacted supported solutions, as well as finite-mass solutions t... Read More about Asymptotic analysis of a doubly nonlinear diffusion equation.

Pushed and pulled fronts in a discrete reaction-diffusion equation (2015)
Journal Article

We consider the propagation of wave fronts connecting unstable and stable uniform solutions to a discrete reaction-diffusion equation on a one-dimensional integer lattice. The dependence of the wavespeed on the coupling strength µ between lattice poi... Read More about Pushed and pulled fronts in a discrete reaction-diffusion equation.

The Hele-Shaw injection problem for an extremely shear-thinning fluid (2015)
Journal Article

We consider Hele-Shaw flows driven by injection of a highly shear-thinning power-law fluid (of exponent n) in the absence of surface tension. We formulate the problem in terms of the streamfunction ψ, which satisfies the p-Laplacian equation ∇·(|∇ψ|p... Read More about The Hele-Shaw injection problem for an extremely shear-thinning fluid.

Orientation-Dependent Pinning and Homoclinic Snaking on a Planar Lattice (2015)
Journal Article

We study homoclinic snaking of one-dimensional, localized states on two-dimensional, bistable lattices via the method of exponential asymptotics. Within a narrow region of parameter space, fronts connecting the two stable states are pinned to the und... Read More about Orientation-Dependent Pinning and Homoclinic Snaking on a Planar Lattice.

FlowerNet: a gene expression correlation metwork for anther and pollen development (2015)
Journal Article

Floral formation, in particular anther and pollen development, is a complex biological process with critical importance for seed set and for targeted plant breeding. Many key transcription factors regulating this process have been identified; however... Read More about FlowerNet: a gene expression correlation metwork for anther and pollen development.

Enhanced waterlogging tolerance in barley by manipulation of expression of the N-end rule pathway E3 ligase PROTEOLYSIS6 (2015)
Journal Article

© 2016 Society for Experimental Biology, Association of Applied Biologists and John Wiley & Sons Ltd. Increased tolerance of crops to low oxygen (hypoxia) during flooding is a key target for food security. In Arabidopsis thaliana (L.) Heynh., the N... Read More about Enhanced waterlogging tolerance in barley by manipulation of expression of the N-end rule pathway E3 ligase PROTEOLYSIS6.

Promotion of testa rupture during garden cress germination involves seed compartment-specific expression and activity of pectin methylesterases (2015)
Journal Article

Pectin methylesterase (PME) controls the methylesterification status of pectins and thereby determines the biophysical properties of plant cell walls, which are important for tissue growth and weakening processes. We demonstrate here that tissue-spec... Read More about Promotion of testa rupture during garden cress germination involves seed compartment-specific expression and activity of pectin methylesterases.

A mathematical model of the human metabolic system and metabolic flexibility (2014)
Journal Article

In healthy subjects some tissues in the human body display metabolic flexibility, by this we mean the ability for the tissue to switch its fuel source between predominantly carbohydrates in the post prandial state and predominantly fats in the fasted... Read More about A mathematical model of the human metabolic system and metabolic flexibility.

Systems Analysis of Auxin Transport in the Arabidopsis Root Apex (2014)
Journal Article

Auxin is a key regulator of plant growth and development. Within the root tip, auxin distribution plays a crucial role specifying developmental zones and coordinating tropic responses. Determining how the organ-scale auxin pattern is regulated at the... Read More about Systems Analysis of Auxin Transport in the Arabidopsis Root Apex.

Vertex-element models for anisotropic growth of elongated plant organs (2013)
Journal Article

New tools are required to address the challenge of relating plant hormone levels, hormone responses, wall biochemistry and wall mechanical properties to organ-scale growth. Current vertex-based models (applied in other contexts) can be unsuitable for... Read More about Vertex-element models for anisotropic growth of elongated plant organs.

The putative influence of the agr operon upon survival mechanisms used by Clostridium acetobutylicum (2013)
Journal Article

The bacterium Clostridium acetobutylicum produces acids as an energy-yielding process during exponential growth. An acidic environment, however, is toxic to the cells and two survival mechanisms are in place to prevent them from dying. Firstly, durin... Read More about The putative influence of the agr operon upon survival mechanisms used by Clostridium acetobutylicum.

Transgenic nematodes as biosensors for metal stress in soil pore water samples (2012)
Journal Article

Caenorhabditis elegans strains carrying stress-reporter green fluorescent protein transgenes were used to explore patterns of response to metals. Multiple stress pathways were induced at high doses by most metals tested, including members of the heat... Read More about Transgenic nematodes as biosensors for metal stress in soil pore water samples.

Continuum limits of pattern formation in hexagonal-cell monolayers (2012)
Journal Article

Intercellular signalling is key in determining cell fate. In closely packed tissues such as epithelia, juxtacrine signalling is thought to be a mechanism for the generation of fine-grained spatial patterns in cell differentiation commonly observed in... Read More about Continuum limits of pattern formation in hexagonal-cell monolayers.