Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation

Vassey, Matthew J.; Figueredo, Grazziela P.; Scurr, David J.; Vasilevich, Aliaksei S.; Vermeulen, Steven; Carlier, Aur�lie; Luckett, Jeni; Beijer, Nick R.M.; Williams, Paul; Winkler, David A.; de Boer, Jan; Ghaemmaghami, Amir M.; Alexander, Morgan R.

doi:10.1002/advs.201903392

All Outputs (5)

Translational pharmacology of an inhaled small molecule ?v?6 integrin inhibitor for idiopathic pulmonary fibrosis (2020)
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Discovery of hemocompatible bacterial biofilm-resistant copolymers (2020)
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© 2020 The Authors Blood-contacting medical devices play an important role within healthcare and are required to be biocompatible, hemocompatible and resistant to microbial colonization. Here we describe a high throughput screen for copolymers with t... Read More about Discovery of hemocompatible bacterial biofilm-resistant copolymers.

Gaussia luciferase as a reporter for quorum sensing in staphylococcus aureus (2020)
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© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Gaussia luciferase (GLuc) is a secreted protein with significant potential for use as a reporter of gene expression in bacterial pathogenicity studies. To date there are relatively few example... Read More about Gaussia luciferase as a reporter for quorum sensing in staphylococcus aureus.

Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo (2020)
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© 2020 The Author(s) Implantation of medical devices can result in inflammation. A large library of polymers is screened, and a selection found to promote macrophage differentiation towards pro- or anti-inflammatory phenotypes. The bioinstructive pro... Read More about Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo.

Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation (2020)
Journal Article

© 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Macrophages play a central role in orchestrating immune responses to foreign materials, which are often responsible for the failure of implanted medical devices. Material t... Read More about Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation.