Human-scale tissues with patterned vascular networks by additive manufacturing of sacrificial sugar-protein composites

Eltaher, Hoda M.; Abukunna, Fatima E.; Ruiz-Cantu, Laura; Stone, Zack; Yang, Jing; Dixon, James E.

doi:10.1016/j.actbio.2020.06.012

All Outputs (5)

Rapidly Transducing and Spatially Localized Magnetofection Using Peptide-Mediated Non-Viral Gene Delivery Based on Iron Oxide Nanoparticles (2020)
Journal Article

Non-viral delivery systems are generally of low efficiency, which limits their use in gene therapy and editing applications. We previously developed a technology termed glycosaminoglycan (GAG)-binding enhanced transduction (GET) to efficiently delive... Read More about Rapidly Transducing and Spatially Localized Magnetofection Using Peptide-Mediated Non-Viral Gene Delivery Based on Iron Oxide Nanoparticles.

Enhanced Cellular Transduction of Nanoparticles Resistant to Rapidly Forming Plasma Protein Coronas (2020)
Journal Article

© 2020 The Authors. Published by Wiley-VCH GmbH Nanoparticles (NPs) are increasingly being developed as biomedical platforms for drug/nucleic acid delivery and imaging. However, in biological fluids, NPs interact with a wide range of proteins that fo... Read More about Enhanced Cellular Transduction of Nanoparticles Resistant to Rapidly Forming Plasma Protein Coronas.

Efficient Delivery of Transducing Polymer Nanoparticles for Gene-mediated Induction of Osteogenesis for Bone Regeneration (2020)
Journal Article

Developing non-viral gene therapy vectors that both protect and functionally deliver nucleic acid cargoes will be vital if gene augmentation and editing strategies are to be effectively combined with advanced regenerative medicine approaches. Current... Read More about Efficient Delivery of Transducing Polymer Nanoparticles for Gene-mediated Induction of Osteogenesis for Bone Regeneration.

Genetically-programmed, mesenchymal stromal cell-laden & mechanically strong 3D bioprinted scaffolds for bone repair (2020)
Journal Article

Human-scale tissues with patterned vascular networks by additive manufacturing of sacrificial sugar-protein composites (2020)
Journal Article

© 2020 Combating necrosis, by supplying nutrients and removing waste, presents the major challenge for engineering large three-dimensional (3D) tissues. Previous elegant work used 3D printing with carbohydrate glass as a cytocompatible sacrificial te... Read More about Human-scale tissues with patterned vascular networks by additive manufacturing of sacrificial sugar-protein composites.