All Outputs (15)
Clinical examination for hyperlinear palms to determine filaggrin genotype: A diagnostic test accuracy study (2021)
Journal Article
Background: Palmar hyperlinearity is a feature of ichthyosis vulgaris, the monogenic skin disorder caused by FLG loss-of-function mutations. Objective: To investigate how well the presence or absence of hyperlinear palms (HLP) detect FLG genotype in... Read More about Clinical examination for hyperlinear palms to determine filaggrin genotype: A diagnostic test accuracy study.
Patterns of Atopic Eczema Disease Activity from Birth through Midlife in 2 British Birth Cohorts (2021)
Journal Article
Importance: Atopic eczema is characterized by a heterogenous waxing and waning course, with variable age of onset and persistence of symptoms. Distinct patterns of disease activity such as early-onset/resolving and persistent disease have been identi... Read More about Patterns of Atopic Eczema Disease Activity from Birth through Midlife in 2 British Birth Cohorts.
Safety of topical corticosteroids in atopic eczema: an umbrella review (2021)
Journal Article
Objective An umbrella review summarising all safety data from systematic reviews of topical corticosteroids (TCS) in adults and children with atopic eczema. Methods Embase, MEDLINE, PubMed, Cochrane Database of Systematic Reviews and the Centre of Ev... Read More about Safety of topical corticosteroids in atopic eczema: an umbrella review.
Realising the full potential of data-enabled trials in the UK: a call for action (2021)
Journal Article
Rationale: Clinical trials are the gold standard for testing interventions. COVID-19 has further raised their public profile, and emphasised the need to deliver better, faster, more efficient trials for patient benefit. Considerable overlap exists be... Read More about Realising the full potential of data-enabled trials in the UK: a call for action.
Evidence-based management of eczema: five things that should be done more and five things that should be dropped (2021)
Journal Article
Purpose of review We provide readers with an evidence-informed opinion on current treatments for eczema (atopic dermatitis) with the intention of improving patient care. We suggest five treatment aspects that should be promoted and five that shou... Read More about Evidence-based management of eczema: five things that should be done more and five things that should be dropped.
Developing the INCLUDE Ethnicity Framework—a tool to help trialists design trials that better reflect the communities they serve (2021)
Journal Article
Background Ensuring that a trial is designed so that its participants reflect those who might benefit from the results, or be spared harms, is key to the potential benefits of the trial reaching all they should. This paper describes the process, f... Read More about Developing the INCLUDE Ethnicity Framework—a tool to help trialists design trials that better reflect the communities they serve.
Interventions for basal cell carcinoma: abridged Cochrane systematic review and grade assessments (2021)
Journal Article
Background Basal cell carcinoma (BCC) is the commonest cancer affecting white?skinned individuals, and worldwide incidence is increasing. Although rarely fatal, BCC is associated with significant morbidity and costs. Objectives To assess the eff... Read More about Interventions for basal cell carcinoma: abridged Cochrane systematic review and grade assessments.
Can atopic eczema and psoriasis coexist? A systematic review and meta?analysis (2021)
Journal Article
Importance: Previous studies report both co-existence and mutual exclusivity of atopic eczema (AE) and psoriasis, but these have not been appraised systematically. Knowledge of such disease association throws light on disease mechanisms and may influ... Read More about Can atopic eczema and psoriasis coexist? A systematic review and meta?analysis.
Clinical integration of fast Raman spectroscopy for Mohs micrographic surgery of basal cell carcinoma (2021)
Journal Article
We present the first clinical integration of a prototype device based on integrated auto-fluorescence imaging and Raman spectroscopy (Fast Raman device) for intra-operative assessment of surgical margins during Mohs micrographic surgery of basal cell... Read More about Clinical integration of fast Raman spectroscopy for Mohs micrographic surgery of basal cell carcinoma.
Association of frequent moisturizer use in early infancy with the development of food allergy (2021)
Journal Article
Background Food allergy is thought to develop through transcutaneous sensitization, especially in the presence of skin barrier impairment and inflammation. Regular moisturizer application to infant skin could potentially promote transcutaneous sensi... Read More about Association of frequent moisturizer use in early infancy with the development of food allergy.
Skin care interventions in infants for preventing eczema and food allergy (2021)
Journal Article
Background Eczema and food allergy are common health conditions that usually begin in early childhood and often occur together in the same people. They can be associated with an impaired skin barrier in early infancy. It is unclear whether trying... Read More about Skin care interventions in infants for preventing eczema and food allergy.
Supporting self-care for eczema: protocol for two randomised controlled trials of ECO (Eczema Care Online) interventions for young people and parents/carers (2021)
Journal Article
Introduction Eczema care requires management of triggers and various treatments. We developed two online behavioural interventions to support eczema care called ECO (Eczema Care Online) for young people and ECO for families. This protocol describes t... Read More about Supporting self-care for eczema: protocol for two randomised controlled trials of ECO (Eczema Care Online) interventions for young people and parents/carers.
Recommended core outcome instruments for health‐related quality of life, long‐term control and itch intensity in atopic eczema trials: results of the HOME VII consensus meeting (2021)
Journal Article
Background: The Harmonising Outcome Measures for Eczema (HOME) initiative has established a core outcome set of domains for atopic eczema (AE) clinical trials. Previous consensus meetings have agreed on preferred instruments for clinician-reported si... Read More about Recommended core outcome instruments for health‐related quality of life, long‐term control and itch intensity in atopic eczema trials: results of the HOME VII consensus meeting.