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Association between topical corticosteroid use and type 2 diabetes in two European population-based adult cohorts (2019)
Journal Article
Andersen, Y. M., Egeberg, A., Ban, L., Gran, S., Williams, H. C., Francis, N. A., Knop, F. K., Gislason, G. H., Skov, L., & Thyssen, J. P. (2019). Association between topical corticosteroid use and type 2 diabetes in two European population-based adult cohorts. Diabetes Care, 42(6), 1095-1103. https://doi.org/10.2337/dc18-2158

Background
Topical corticosteroids (CS) are commonly used to treat inflammatory skin conditions including eczema and psoriasis. While topical CS package inserts describe hyperglycaemia and glycosuria as adverse drug reactions, it is unclear whether... Read More about Association between topical corticosteroid use and type 2 diabetes in two European population-based adult cohorts.

Navigating the landscape of core outcome set development in dermatology (2019)
Journal Article
Prinsen, C. A., Spuls, P. I., Kottner, J., Thomas, K. S., Apfelbacher, C., Chalmers, J. R., Deckert, S., Furue, M., Gerbens, L., Kirkham, J., Simpson, E. L., Alam, M., Balzer, K., Beeckman, D., Eleftheriadou, V., Ezzedine, K., Horbach, S. E., Ingram, J. R., Layton, A. M., Weller, K., …Schmitt, J. (2019). Navigating the landscape of core outcome set development in dermatology. Journal of The American Academy of Dermatology, 81(1), 297-305. https://doi.org/10.1016/j.jaad.2019.03.009

© 2019 American Academy of Dermatology, Inc. The development of core outcome sets (COSs; ie, a minimum set of core outcomes that should be measured and reported in all trials or in clinical practice for a specific condition) in dermatology is increas... Read More about Navigating the landscape of core outcome set development in dermatology.

Cochrane reviews and dermatological trials outcome concordance: why Core Outcome Sets could make trial results more usable (2018)
Journal Article
Schmitt, J., Lange, T., Kottner, J., Prinsen, C. A. C., Weberschock, T., Hahnel, E., Apfelbacher, C., Brandstetter, S., Dreher, A., Stevens, G., Burden-Teh, E., Rogers, N., Spuls, P., Grainge, M. J., Williams, H. C., Jacobi, L., & Cochrane Skin Core Outcome Set Initiative (CS-COUSIN). (2019). Cochrane reviews and dermatological trials outcome concordance: why Core Outcome Sets could make trial results more usable. Journal of Investigative Dermatology, 139(5), 1045-1053. https://doi.org/10.1016/j.jid.2018.11.019

Evidence-based healthcare requires that relevant outcomes for patients are included in clinical trials which investigating treatment effects allowing subsequent systematic reviews to summarize all relevant evidence to guide clinical practice. Current... Read More about Cochrane reviews and dermatological trials outcome concordance: why Core Outcome Sets could make trial results more usable.

Computer assisted diagnosis techniques (dermoscopy and spectroscopy-based) for diagnosing skin cancer in adults (2018)
Journal Article
Ferrante di Ruffano, L., Takwoingi, Y., Dinnes, J., Chuchu, N., Bayliss, S. E., Davenport, C., Matin, R. N., Godfrey, K., O'Sullivan, C., Gulati, A., Chan, S. A., Durack, A., O'Connell, S., Gardiner, M. D., Bamber, J., Deeks, J. J., & Williams, H. C. (2018). Computer assisted diagnosis techniques (dermoscopy and spectroscopy-based) for diagnosing skin cancer in adults. Cochrane Database of Systematic Reviews, 2018(12), Article CD013186. https://doi.org/10.1002/14651858.CD013186

Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and cutaneous squamous cell carcinoma (cSCC) are high‐risk skin cancers which have the potentia... Read More about Computer assisted diagnosis techniques (dermoscopy and spectroscopy-based) for diagnosing skin cancer in adults.

Are environmental factors for atopic eczema in ISAAC Phase Three due to reverse causation? (2018)
Journal Article
Rutter, C., Silverwood, R. J., Williams, H. C., Elwood, P., Asher, I., Garcia-Marcos, L., Strachan, D. P., Pearce, N., Langan, S. M., & ISAAC Phase Three Group. (2019). Are environmental factors for atopic eczema in ISAAC Phase Three due to reverse causation?. Journal of Investigative Dermatology, 139(5), 1023-1036. https://doi.org/10.1016/j.jid.2018.08.035

Some previously described environmental associations for atopic eczema (AE) may be due to reverse causation. We explored the role of reverse causation by comparing individual- and school-level results for multiple AE risk factors.

ISAAC Phase Thre... Read More about Are environmental factors for atopic eczema in ISAAC Phase Three due to reverse causation?.

Adding emollient bath additives to standard eczema management for children with eczema: the BATHE RCT (2018)
Journal Article
Santer, M., Rumsby, K., Ridd, M. J., Francis, N. A., Stuart, B., Chorozoglou, M., Roberts, A., Liddiard, L., Nollett, C., Hooper, J., Prude, M., Wood, W., Thomas-Jones, E., Becque, T., Thomas, K. S., Williams, H. C., & Little, P. (2018). Adding emollient bath additives to standard eczema management for children with eczema: the BATHE RCT. Health Technology Assessment, 22(57), 1-116. https://doi.org/10.3310/hta22570

Plain English Summary
Eczema is very common in children and can have a significant impact, causing itching and sleep problems. The main treatments are emollients, which are used to moisturise the skin, and steroid creams or ointments to treat flare-... Read More about Adding emollient bath additives to standard eczema management for children with eczema: the BATHE RCT.

Feasibility of weekly participant‐reported data collection in a pragmatic randomised controlled trial in primary care: experiences from the BATHE trial (Bath Additives for the Treatment of cHildhood Eczema) (2018)
Journal Article
Stuart, B., Rumsby, K., Santer, M., Ridd, M. J., Francis, N. A., Chorozoglou, M., Spreadbury, C., Steele, M., Nollett, C., Liddiard, L., Prude, M., Hooper, J., Thomas‐Jones, E., Roberts, A., Thomas, K. S., Williams, H. C., & Little, P. (2018). Feasibility of weekly participant‐reported data collection in a pragmatic randomised controlled trial in primary care: experiences from the BATHE trial (Bath Additives for the Treatment of cHildhood Eczema). Trials, 19, Article 582. https://doi.org/10.1186/s13063-018-2962-3

Background: Patient‐reported outcomes measures in clinical trials ensure that evaluations of effectiveness focus on outcomes that are important to patients. In relapsing‐remitting conditions such as eczema, repeated measurements may allow a more accu... Read More about Feasibility of weekly participant‐reported data collection in a pragmatic randomised controlled trial in primary care: experiences from the BATHE trial (Bath Additives for the Treatment of cHildhood Eczema).

Changes in health in the countries of the UK and 150 English Local Authority areas 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 (2018)
Journal Article
Steel, N., Ford, J. A., Newton, J. N., Davis, A. C. J., Vos, T., Naghavi, M., Glenn, S., Hughes, A., Dalton, A. M., Stockton, D., Humphreys, C., Dallat, M., Schmidt, J., Flowers, J., Fox, S., Abubakar, I., Aldridge, R. W., Brayne, C., Baker, A., Brugha, T., …Murray, C. J. L. (2018). Changes in health in the countries of the UK and 150 English Local Authority areas 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet, 392(10158), 1647-1661. https://doi.org/10.1016/S0140-6736%2818%2932207-4

Background
Previous studies have reported national and regional Global Burden of Disease (GBD) estimates for the UK. Because of substantial variation in health within the UK, action to improve it requires comparable estimates of disease burden and r... Read More about Changes in health in the countries of the UK and 150 English Local Authority areas 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016.

Development of a core outcome set for therapeutic clinical trials enrolling dogs with atopic dermatitis (COSCAD’18) (2018)
Journal Article
Olivry, T., Bensignor, E., Favrot, C., Griffin, C. E., Hill, P. B., Mueller, R. S., Plant, J. D., & Williams, H. C. (2018). Development of a core outcome set for therapeutic clinical trials enrolling dogs with atopic dermatitis (COSCAD’18). BMC Veterinary Research, 14, 1-8. https://doi.org/10.1186/s12917-018-1569-y

Background: For decades, the efficacy of interventions in clinical trials enrolling dogs with atopic dermatitis (AD) relied on heterogeneous evaluations of skin lesions and pruritus using unvalidated tools. Although some instruments for clinical sign... Read More about Development of a core outcome set for therapeutic clinical trials enrolling dogs with atopic dermatitis (COSCAD’18).

What’s new in psoriasis treatment? An analysis of systematic reviews published in 2015 (2018)
Journal Article
Foulkes, A., Ferguson, F., Grindlay, D. J., Williams, H. C., Griffiths, C., & Warren, R. (2018). What’s new in psoriasis treatment? An analysis of systematic reviews published in 2015. Clinical and Experimental Dermatology, 43(7), 759-765. https://doi.org/10.1111/ced.13601

This review provides a summary of key findings from 27 systematic reviews of 51 articles first published or indexed during 2015, focusing on the treatment of psoriasis as well as precision medicine in psoriasis. Evidence supports weight loss interven... Read More about What’s new in psoriasis treatment? An analysis of systematic reviews published in 2015.

Home interventions and light therapy for treatment of vitiligo (HI-Light Vitiligo Trial): study protocol for a randomized controlled trial (2018)
Journal Article
Haines, R. H., Thomas, K. S., Montgomery, A. A., Ravenscroft, J. C., Akram, P., Chalmers, J., Whitman, D., Duley, L., Eleftheriadou, V., Meakin, G., Mitchell, E., White, J., Rogers, A., Sach, T., Santer, M., Tan, W., Hepburn, T., Williams, H. C., & Batchelor, J. M. (2018). Home interventions and light therapy for treatment of vitiligo (HI-Light Vitiligo Trial): study protocol for a randomized controlled trial. BMJ Open, 8(4), Article e018649. https://doi.org/10.1136/bmjopen-2017-018649

Vitiligo is a condition resulting in white patches on the skin. People with vitiligo can suffer from low self-esteem, psychological disturbance and diminished quality of life. Vitiligo is often poorly managed, partly due to lack of high quality evide... Read More about Home interventions and light therapy for treatment of vitiligo (HI-Light Vitiligo Trial): study protocol for a randomized controlled trial.

Core outcome sets in dermatology: report from the second meeting of the International Cochrane Skin Group Core Outcome Set Initiative (2018)
Journal Article
Kottner, J., Jacobi, L., Hahnel, E., Alam, M., Beeckman, D., Busard, C., Chalmers, J., Deckert, S., Eleftheriadou, V., Furlan, K., Horbach, S. E., Kirkham, J. J., Nast, A., Thiboutot, D., Thorlacius, L., Weller, K., Williams, H. C., & Schmitt, J. (2018). Core outcome sets in dermatology: report from the second meeting of the International Cochrane Skin Group Core Outcome Set Initiative. British Journal of Dermatology, 178(4), Article e279-e285. https://doi.org/10.1111/bjd.16324

Results of clinical trials are the most important information source for generating external clinical evidence. The use of different outcomes across trials, which investigate similar interventions for similar patient groups, significantly limits the... Read More about Core outcome sets in dermatology: report from the second meeting of the International Cochrane Skin Group Core Outcome Set Initiative.

Doxycycline compared to prednisolone therapy for patients with bullous pemphigoid: cost-effectiveness analysis of the BLISTER trial (2018)
Journal Article
Mason, J. M., Chalmers, J., Godec, T. R., Nunn, A. J., Kirtschig, G., Wojnarowska, F., Childs, M., Whitham, D., Schmidt, E., Harman, K., Walton, S., Chapman, A., & Williams, H. C. (in press). Doxycycline compared to prednisolone therapy for patients with bullous pemphigoid: cost-effectiveness analysis of the BLISTER trial. British Journal of Dermatology, 178, https://doi.org/10.1111/bjd.16006

Background: Bullous pemphigoid (BP) is an autoimmune blistering skin disorder associated with significant morbidity and mortality. Doxycycline and prednisolone to treat bullous pemphigoid were compared within a randomised controlled trial (RCT).... Read More about Doxycycline compared to prednisolone therapy for patients with bullous pemphigoid: cost-effectiveness analysis of the BLISTER trial.

Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a critical appraisal (2018)
Journal Article
Thomson, J., Wernham, A., & Williams, H. C. (2018). Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a critical appraisal. British Journal of Dermatology, 178(4), 897-902. https://doi.org/10.1111/bjd.16317

Aim

Blauvelt et al. (The Lancet 2017; 389: 2287-303) aimed to compare the long-term efficacy and safety of dupilumab with medium-potency topical corticosteroids (TCS) versus placebo with TCS in adults with moderate-to-severe atopic dermatitis (AD)... Read More about Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a critical appraisal.

Automated multimodal spectral histopathology for quantitative diagnosis of residual tumour during basal cell carcinoma surgery (2017)
Journal Article
Boitor, R., Kong, K., Shipp, D., Varma, S., Koloydenko, A., Kusum, K., Elsheikh, S., Bakker Schut, T., Caspers, P., Puppels, G., Wolf, M. V. D., Sokolova, E., Nijsten, T., Salence, B., Williams, H. C., & Ioan, N. (in press). Automated multimodal spectral histopathology for quantitative diagnosis of residual tumour during basal cell carcinoma surgery. Biomedical Optics Express, 8(12), https://doi.org/10.1364/BOE.8.005749

Multimodal spectral histopathology (MSH), an optical technique combining tissue auto-fluorescence (AF) imaging and Raman micro-spectroscopy (RMS), was previously proposed for detection of residual basal cell carcinoma (BCC) at the surface of surgical... Read More about Automated multimodal spectral histopathology for quantitative diagnosis of residual tumour during basal cell carcinoma surgery.

Measuring long-term disease control in patients with atopic dermatitis: A validation study of well-controlled weeks (2017)
Journal Article
Langan, S. M., Stuart, B., Bradshaw, L., Schmitt, J., Williams, H. C., & Thomas, K. S. (2017). Measuring long-term disease control in patients with atopic dermatitis: A validation study of well-controlled weeks. Journal of Allergy and Clinical Immunology, 140(6), 1580-1586. https://doi.org/10.1016/j.jaci.2017.02.043

Background:Because atopic dermatitis (AD) is a relapsing, remitting disease, assessing long‐term control is important. Well controlled weeks (WCWs) have been used to assess asthma long‐term control, but never validated for AD.
Objectives: To assess... Read More about Measuring long-term disease control in patients with atopic dermatitis: A validation study of well-controlled weeks.

Development and validation of an algorithm to accurately identify atopic eczema patients in primary care electronic health records from the UK (2017)
Journal Article
Abuabara, K., Magyari, A., Hoffstad, O., Jabbar-Lopez, Z., Smeeth, L., Williams, H., Gelfand, J., Margolis, D., & Langan, S. (2017). Development and validation of an algorithm to accurately identify atopic eczema patients in primary care electronic health records from the UK. Journal of Investigative Dermatology, 137(8), 1655-1662. https://doi.org/10.1016/j.jid.2017.03.029

Electronic health records hold great promise for clinical and epidemiologic research. Undertaking atopic eczema (AE) research using such data is challenging due to its episodic and heterogeneous nature. We sought to develop and validate a diagnostic... Read More about Development and validation of an algorithm to accurately identify atopic eczema patients in primary care electronic health records from the UK.

Is speed of healing a good predictor of eventual healing of pyoderma gangrenosum? (2016)
Journal Article
Wilkes, S. R., Williams, H. C., Ormerod, A. D., Craig, F. E., Greenlaw, N., Norrie, J., Mitchell, E., Mason, J. M., & Thomas, K. S. (2016). Is speed of healing a good predictor of eventual healing of pyoderma gangrenosum?. Journal of The American Academy of Dermatology, 75(6), 1216-1220.e2. https://doi.org/10.1016/j.jaad.2016.07.049

Background: Pyoderma gangrenosum is a rare inflammatory skin condition. The STOPGAP studies compared treatments for pyoderma gangrenosum using a primary outcome of healing speed at 6 weeks.
Objective: Using data from both studies we assessed the pre... Read More about Is speed of healing a good predictor of eventual healing of pyoderma gangrenosum?.

How Clinically Relevant Are Treatment Comparisons of Topical Calcineurin Inhibitor Trials for Atopic Eczema? (2016)
Journal Article
Wilkes, S. R., Nankervis, H., Tavernier, E., Maruani, A., & Williams, H. C. (2016). How Clinically Relevant Are Treatment Comparisons of Topical Calcineurin Inhibitor Trials for Atopic Eczema?. Journal of Investigative Dermatology, 136(10), 1944-1949. https://doi.org/10.1016/j.jid.2016.05.104

We sought to explore the architecture of trials of calcineurin inhibitors for atopic eczema to document the extent to which comparisons with active treatments such as topical corticosteroids (TCS) might have been included or avoided. We identified al... Read More about How Clinically Relevant Are Treatment Comparisons of Topical Calcineurin Inhibitor Trials for Atopic Eczema?.