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Core outcome sets in dermatology: report from the second meeting of the International Cochrane Skin Group Core Outcome Set Initiative

Kottner, Jan; Jacobi, Lena; Hahnel, Elisabeth; Alam, Murad; Beeckman, Dimitri; Busard, Celine; Chalmers, J.R.; Deckert, Stefanie; Eleftheriadou, Viktoria; Furlan, Karina; Horbach, Sophie E.R.; Kirkham, Jamie J.; Nast, Alexander; Thiboutot, Diane; Thorlacius, Linnea; Weller, Karsten; Williams, Hywel C.; Schmitt, Jochen

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Authors

Jan Kottner

Lena Jacobi

Elisabeth Hahnel

Murad Alam

Dimitri Beeckman

Celine Busard

J.R. Chalmers

Stefanie Deckert

Viktoria Eleftheriadou

Karina Furlan

Sophie E.R. Horbach

Jamie J. Kirkham

Alexander Nast

Diane Thiboutot

Linnea Thorlacius

Karsten Weller

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HYWEL WILLIAMS HYWEL.WILLIAMS@NOTTINGHAM.AC.UK
Professor of Dermato-Epidemiology

Jochen Schmitt



Abstract

Results of clinical trials are the most important information source for generating external clinical evidence. The use of different outcomes across trials, which investigate similar interventions for similar patient groups, significantly limits the interpretation, comparability and clinical application of trial results. Core outcome sets (COSs) aim to overcome this limitation. A COS is an agreed standardized collection of outcomes that should be measured and reported in all clinical trials for a specific clinical condition. The Core Outcome Set Initiative within the Cochrane Skin Group (CSG-COUSIN) supports the development of core outcomes in dermatology.

In the second CSG-COUSIN meeting held in 2017, 11 COS development groups working on skin diseases presented their current work. The presentations and discussions identified the following overarching methodological challenges for COS development in dermatology: it is not always easy to define the disease focus of a COS; the optimal method for outcome domain identification and level of detail needed to specify such domains is challenging to many; decision rules within Delphi surveys need to be improved; appropriate ways of patient involvement are not always clear. In addition, there appear to be outcome domains that may be relevant as potential core outcome domains for the majority of skin diseases. The close collaboration between methodologists in the Core Outcome Set Initiative and the international Cochrane Skin Group has major advantages for trialists, systematic reviewers and COS developers.

Citation

Kottner, J., Jacobi, L., Hahnel, E., Alam, M., Beeckman, D., Busard, C., …Schmitt, J. (2018). Core outcome sets in dermatology: report from the second meeting of the International Cochrane Skin Group Core Outcome Set Initiative. British Journal of Dermatology, 178(4), Article e279-e285. https://doi.org/10.1111/bjd.16324

Journal Article Type Article
Acceptance Date Oct 16, 2017
Online Publication Date Feb 14, 2018
Publication Date Apr 1, 2018
Deposit Date Oct 20, 2017
Publicly Available Date Mar 28, 2024
Journal British Journal of Dermatology
Print ISSN 0007-0963
Electronic ISSN 1365-2133
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 178
Issue 4
Article Number e279-e285
DOI https://doi.org/10.1111/bjd.16324
Public URL https://nottingham-repository.worktribe.com/output/962161
Publisher URL http://onlinelibrary.wiley.com/doi/10.1111/bjd.16324/abstract

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