All Outputs (58)

Dopamine D1 receptor involvement in latent inhibition and overshadowing (2012)
Journal Article

Latent inhibition (LI) manifests as poorer conditioning to a stimulus that has previously been experienced without consequence. There is good evidence of dopaminergic modulation of LI, as the e?ect is reliably disrupted by the indirect dopamine (DA... Read More about Dopamine D1 receptor involvement in latent inhibition and overshadowing.

When to hold that thought: an experimental study showing reduced inhibition of pre-trained associations in schizophrenia (2012)
Journal Article

Schizophrenia encompasses a wide variety of cognitive dysfunctions, a number of which can be understood as deficits of inhibition. To date, no research has examined ‘conditioned inhibition’ in schizophrenia - the ability of a stimulus that signals th... Read More about When to hold that thought: an experimental study showing reduced inhibition of pre-trained associations in schizophrenia.

Opposing effects of 5,7-DHT lesions to the core and shell of the nucleus accumbens on the processing of irrelevant stimuli (2012)
Journal Article

There is good evidence that forebrain serotonergic systems modulate cognitive flexibility. Latent inhibition (LI) is a cross-species phenomenon which manifests as poor conditioning to a stimulus that has previously been experienced without consequenc... Read More about Opposing effects of 5,7-DHT lesions to the core and shell of the nucleus accumbens on the processing of irrelevant stimuli.

Dopamine in nucleus accumbens: salience modulation in latent inhibition and overshadowing (2012)
Journal Article

Latent inhibition (LI) is demonstrated when non-reinforced pre-exposure to a to-be-conditioned stimulus retards later learning. Learning is similarly retarded in overshadowing, in this case using the relative intensity of competing cues to manipulate... Read More about Dopamine in nucleus accumbens: salience modulation in latent inhibition and overshadowing.

A clozapine-like effect of cyproheptadine on progressive ratio schedule performance (2011)
Journal Article

The atypical antipsychotic drug clozapine has multiple pharmacological actions, some of which, including 5-hydroxytryptamine (5-HT2) and histamine (H1) receptor antagonist effects, are shared by the non-selective 5-HT receptor antagonist cyproheptadi... Read More about A clozapine-like effect of cyproheptadine on progressive ratio schedule performance.

Catecholaminergic depletion in nucleus accumbens enhances trace conditioning (2011)
Journal Article

Purpose: To examine the effect of dopamine depletion in nucleus accumbens on trace conditioning; to distinguish the role of core and shell sub-regions, as far as possible. Material/Methods: 6-hydroxydopamine was used to lesion dopamine terminals with... Read More about Catecholaminergic depletion in nucleus accumbens enhances trace conditioning.

The effect of catecholaminergic depletion within the prelimbic and infralimbic medial prefrontal cortex on recognition memory for recency, location, and objects (2011)
Journal Article

There is good evidence that the medial prefrontal cortex (mPFC) is involved in different aspects of recognition memory. However, the mPFC is a heterogeneous structure, and the contribution of the prelimbic (PL) and infralimbic (IL) cortices to recogn... Read More about The effect of catecholaminergic depletion within the prelimbic and infralimbic medial prefrontal cortex on recognition memory for recency, location, and objects.

Reduced dopamine function within the medial shell of the nucleus accumbens enhances latent inhibition (2011)
Journal Article

Latent inhibition (LI) manifests as poorer conditioning to a CS that has previously been presented without consequence. There is some evidence that LI can be potentiated by reduced mesoaccumbal dopamine (DA) function but the locus within the nucleus... Read More about Reduced dopamine function within the medial shell of the nucleus accumbens enhances latent inhibition.

Impaired Pavlovian conditioned inhibition in offenders with personality disorders (2011)
Journal Article

Certain types of violent offending are often accompanied by evidence of personality disorders (PDs), a range of heterogeneous conditions characterised by disinhibited behaviours that are generally described as impulsive. The tasks previously used to... Read More about Impaired Pavlovian conditioned inhibition in offenders with personality disorders.

Associative learning in ADHD: improved expression under methylphenidate (2011)
Journal Article

Attention Deficit/Hyperactivity Disorder (ADHD) is characterised by developmentally inappropriate levels of inattention, impulsivity and hyperactivity. As might be expected of a disorder in which inhibitory deficits form part of the diagnostic criter... Read More about Associative learning in ADHD: improved expression under methylphenidate.

The normal inhibition of associations is impaired by clonidine in Tourette syndrome (2011)
Journal Article

Objective: We examined the inhibition of stimulus-stimulus associations (formally ‘conditioned inhibition’) in Tourette syndrome (TS). Method: The present study used video game style conditioned inhibition procedures suitable for children and adolesc... Read More about The normal inhibition of associations is impaired by clonidine in Tourette syndrome.

Dissociable roles of dopamine within the core and medial shell of the nucleus accumbens in memory for objects and place (2010)
Journal Article

There is increasing focus on the role of the nucleus accumbens (NAc) in learning and memory, but there is little consensus as to how the core and medial shell subregions of the NAc contribute to these processes. In the current experiments, we used sp... Read More about Dissociable roles of dopamine within the core and medial shell of the nucleus accumbens in memory for objects and place.

Catecholaminergic depletion within the prelimbic medial prefrontal cortex enhances latent inhibition (2010)
Journal Article

Latent inhibition (LI) refers to the reduction in conditioning to a stimulus that has received repeated non-reinforced pre-exposure. Investigations into the neural substrates of LI have focused on the nucleus accumbens (NAc) and its inputs from the h... Read More about Catecholaminergic depletion within the prelimbic medial prefrontal cortex enhances latent inhibition.

Corticosterone differences rather than social housing predict performance of T-maze alternation in male CD-1 mice (2009)
Journal Article

This study examined the effects of social housing manipulations on body weight, corticosterone levels, and performance of T-maze alternation in male CD-1 mice. Males that adopted a dominant social rank were heavier than those that adopted a subordina... Read More about Corticosterone differences rather than social housing predict performance of T-maze alternation in male CD-1 mice.

There’s no place like home: cage odours and place preference in subordinate CD-1 male mice (2006)
Journal Article

Prior studies using mice have shown that scent marks are an important source of information and can cause behavioural changes in other individuals. Studies have also shown that scent marks in the environment can affect the outcome of social interacti... Read More about There’s no place like home: cage odours and place preference in subordinate CD-1 male mice.

What’s special about the ethical challenges of studying disorders with altered brain activity?
Book Chapter

Where there is no viable alternative, studies of neuronal activity are conducted on animals. The use of animals, particularly for invasive studies of the brain, raises a number of ethical issues. Practical or normative ethics are enforced by legislat... Read More about What’s special about the ethical challenges of studying disorders with altered brain activity?.

Effects of SKF-83566 and haloperidol on performance on progressive ratio schedules maintained by sucrose and corn oil reinforcement: quantitative analysis using a new model derived from the Mathematical Principles of Reinforcement (MPR)
Journal Article

Rationale Mathematical models can assist the interpretation of the effects of interventions on schedule-controlled behaviour and help to differentiate between processes that may be confounded in traditional performance measures such as response rate... Read More about Effects of SKF-83566 and haloperidol on performance on progressive ratio schedules maintained by sucrose and corn oil reinforcement: quantitative analysis using a new model derived from the Mathematical Principles of Reinforcement (MPR).

Effect of orexin-B-saporin-induced lesions of the lateral hypothalamus on performance on a progressive ratio schedule
Journal Article

It has been suggested that a sub-population of orexinergic neurones whose somata lie in the lateral hypothalamic area (LHA) play an important role in regulating the reinforcing value of both food and drugs. This experiment examined the effect of disr... Read More about Effect of orexin-B-saporin-induced lesions of the lateral hypothalamus on performance on a progressive ratio schedule.