Skip to main content

Research Repository

See what's under the surface

Advanced Search

Opposing effects of 5,7-DHT lesions to the core and shell of the nucleus accumbens on the processing of irrelevant stimuli

Nelson, Andrew J.D.; Thur, Karen E.; Marsden, Charles A.; Cassaday, Helen J.

Authors

Andrew J.D. Nelson

Karen E. Thur

Charles A. Marsden

Helen J. Cassaday



Abstract

There is good evidence that forebrain serotonergic systems modulate cognitive flexibility. Latent inhibition (LI) is a cross-species phenomenon which manifests as poor conditioning to a stimulus that has previously been experienced without consequence and is widely considered an index of the ability to ignore irrelevant stimuli. While much research has focused on dopaminergic mechanisms underlying LI, there is also considerable evidence of serotonergic modulation. However, the neuroanatomical locus of these effects remains poorly understood. Previous work has identified the nucleus accumbens (NAc) as a key component of the neural circuit underpinning LI and furthermore, this work has shown that the core and shell subregions of the NAc contribute differentially to the expression of LI. To examine the role of the serotonergic input to NAc in LI, we tested animals with 5,7-dihydroxytryptamine (5,7-DHT) lesions to the core and shell subregions on LI assessed under experimental conditions that produce LI in shams and subsequently with weak stimulus pre-exposure designed to prevent the emergence of LI in shams. We found that serotonergic deafferentation of the core disrupted LI whereas 5,7-DHT lesions to the shell produced the opposite effect and potentiated LI.

Journal Article Type Article
Publication Date May 1, 2012
Journal International Journal of Neuropsychopharmacology
Print ISSN 1461-1457
Electronic ISSN 1461-1457
Publisher Oxford University Press (OUP)
Peer Reviewed Peer Reviewed
Volume 15
Issue 4
APA6 Citation Nelson, A. J., Thur, K. E., Marsden, C. A., & Cassaday, H. J. (2012). Opposing effects of 5,7-DHT lesions to the core and shell of the nucleus accumbens on the processing of irrelevant stimuli. International Journal of Neuropsychopharmacology, 15(4), doi:10.1017/S1461145711000599
DOI https://doi.org/10.1017/S1461145711000599
Keywords Core; latent inhibition; nucleus accumbens; serotonin; shell
Publisher URL http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8536928
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nd-sa/4.0

Files

Cassaday_Opposing_effects_of_5,7-DHT_lesions_to_the_core.pdf (161 Kb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nd-sa/4.0





You might also like



Downloadable Citations

;