All Outputs (65)

Human antimicrobial peptides in ocular surface defense (2017)
Journal Article

Sight depends on the passage of light through the transparent cornea and being focused on the fovea. Its exposed position renders it vulnerable to microbial infection. The cornea has developed a wide array of defense mechanisms against infection, of... Read More about Human antimicrobial peptides in ocular surface defense.

3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review (2017)
Journal Article

In recent years, there has been increased research interest in generating corneal substitutes, either for use in the clinic or as in vitro corneal models. The advancement of 3D microfabrication technologies has allowed the reconstruction of the nativ... Read More about 3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review.

Cultivation and characterisation of the surface markers and carbohydrate profile of human corneal endothelial cells (2016)
Journal Article

Background The study aims to characterise human corneal endothelial cell (HCEnC) cultures generated by the peel?and?digest method based on their surface protein/carbohydrate expression pattern. Methods Quantitative polymerase chain reaction was... Read More about Cultivation and characterisation of the surface markers and carbohydrate profile of human corneal endothelial cells.

Scrolling Characteristics of Pre-Descemet Endothelial Keratoplasty Tissue: An Ex Vivo Study (2016)
Journal Article

Purpose To evaluate the scrolling propensity of pre-Descemet endothelial keratoplasty (PDEK) tissue and to compare it with each component of the PDEK tissue, namely the pre-Descemet layer (Dua's layer [PDL]) and the Descemet membrane (DM). Desi... Read More about Scrolling Characteristics of Pre-Descemet Endothelial Keratoplasty Tissue: An Ex Vivo Study.

Effect of culture medium on propagation and phenotype of corneal stroma-derived stem cells (2015)
Journal Article

Background: The limbal area of the corneal stroma has been identified as a source of mesenchymal-like stem cells, which have potential for exploitation as a cell therapy. However, the optimal culture conditions are disputed and few direct media compa... Read More about Effect of culture medium on propagation and phenotype of corneal stroma-derived stem cells.

Corneal Decellularization: A Method of Recycling Unsuitable Donor Tissue for Clinical Translation? (2015)
Journal Article

Background: There is a clinical need for biomimetic corneas that are as effective, preferably superior, to cadaveric donor tissue. Decellularized tissues are advantageous compared to synthetic or semi-synthetic engineered tissues in that the native m... Read More about Corneal Decellularization: A Method of Recycling Unsuitable Donor Tissue for Clinical Translation?.

Clinical evaluation and characterisation of corneal vascularisation (2015)
Journal Article

Background/aims: To clinically characterise corneal neovascularisation (CVas) with a view to elaborate clinical presentations and to standardise descriptors for clinical evaluation and research. Methods: Corneas of 165 patients with CVas due to a va... Read More about Clinical evaluation and characterisation of corneal vascularisation.

Corneal hypoesthesia with normal sub-basal nerve density following surgery for trigeminal neuralgia (2015)
Journal Article

Calcified corneal nerves (2015)
Journal Article

In vitro studies on the antimicrobial peptide human beta-defensin 9 (HBD9): signalling pathways and pathogen-related response (an American Ophthalmological Society thesis) (2014)
Journal Article

Purpose: Human β-defensins (HBDs) are an important part of the innate immune host defense at the ocular surface. Unlike other defensins, expression of HBD9 at the ocular surface is reduced during microbial infection, but activation of toll-like recep... Read More about In vitro studies on the antimicrobial peptide human beta-defensin 9 (HBD9): signalling pathways and pathogen-related response (an American Ophthalmological Society thesis).

The collagen matrix of the human trabecular meshwork is an extension of the novel pre-Descemet's layer (Dua's layer) (2014)
Journal Article

Pre-Descemet's endothelial keratoplasty (PDEK) (2014)
Journal Article

A new surgical technique for endothelial keratoplasty is described, in which the composite of pre-Descemet's layer (Dua's layer) with Descemet's membrane and endothelium is transplanted subsequent to the removal of the recipient's Descemet's membrane... Read More about Pre-Descemet's endothelial keratoplasty (PDEK).

Anaesthetic corneas with intact sub-basal nerve plexus (2014)
Journal Article

Collagen cross-linking with photoactivated riboflavin (PACK-CXL) for the treatment of advanced infectious keratitis with corneal melting (2014)
Journal Article

Concise review: evidence for CD34 as a common marker for diverse progenitors (2014)
Journal Article

CD34 is a transmembrane phosphoglycoprotein, first identified on hematopoietic stem and progenitor cells. Clinically, it is associated with the selection and enrichment of hematopoietic stem cells for bone marrow transplants. Due to these historical... Read More about Concise review: evidence for CD34 as a common marker for diverse progenitors.

Optimised laser microdissection of the human ocular surface epithelial regions for microarray studies (2013)
Journal Article

Background The most important challenge of performing insitu transcriptional profiling of the human ocular surface epithelial regions is obtaining samples in sufficient amounts, without contamination from adjacent tissue, as the region of interest i... Read More about Optimised laser microdissection of the human ocular surface epithelial regions for microarray studies.

Profile of sight-threatening infectious keratitis: a prospective study (2012)
Journal Article

Corneal Densitometry as an Indicator of Corneal Health (2011)
Journal Article

Purpose To establish prospectively the normal values of corneal density of healthy subjects using the Pentacam Scheimpflug system (Oculus, Inc., Wetzlar, Germany) and to investigate alteration in corneal density during active and healed stages of ba... Read More about Corneal Densitometry as an Indicator of Corneal Health.

Increased Expression of Hepcidin and Toll-Like Receptors 8 and 10 in Viral Keratitis (2011)
Journal Article

Purpose: Antimicrobial peptides (AMPs) and toll-like receptors (TLRs) form part of the “chemical barrier” of the ocular surface to microbes. Evidence suggests that pathogen recognition by TLR releases AMPs, altering AMP-TLR profiles in pathologic... Read More about Increased Expression of Hepcidin and Toll-Like Receptors 8 and 10 in Viral Keratitis.

Validation of Endogenous Control Genes for Gene Expression Studies on Human Ocular Surface Epithelium (2011)
Journal Article