All Outputs (170)

Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis (2021)
Journal Article

Objective Liver biopsy is still needed for fibrosis staging in many patients with non-alcoholic fatty liver disease. The aims of this study were to evaluate the individual diagnostic performance of liver stiffness measurement by vibration controlled... Read More about Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis.

Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis (2021)
Journal Article

Background and Aims: Vibration-controlled transient elastography (VCTE), point shear wave elastography (pSWE), two-dimensional shear wave elastography (2DSWE), magnetic resonance elastography (MRE), and magnetic resonance imaging (MRI) are proposed a... Read More about Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis.

Incidence and risk factors of anti-tuberculosis drug induced liver injury (DILI): Large cohort study involving 4652 Chinese adult tuberculosis patients (2021)
Journal Article

Background and Aims: Anti-tuberculosis drugs remain as an important cause of drug-induced liver injury (DILI) worldwide. Adverse drug reactions reduce the effectiveness of treatment. We aimed to determine the incidence and risk factors associated wit... Read More about Incidence and risk factors of anti-tuberculosis drug induced liver injury (DILI): Large cohort study involving 4652 Chinese adult tuberculosis patients.

Longitudinal assessment of symptoms and risk of SARS-CoV-2 infection in healthcare workers across 5 hospitals to understand ethnic differences in infection risk. (2021)
Journal Article

Background:: Healthcare workers (HCWs) have increased rates of SARS-CoV-2 infection compared with the general population. We aimed to understand ethnic differences in SARS-CoV-2 seropositivity among hospital healthcare workers depending on their hosp... Read More about Longitudinal assessment of symptoms and risk of SARS-CoV-2 infection in healthcare workers across 5 hospitals to understand ethnic differences in infection risk..

What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline? (2021)
Journal Article

Objectives: To examine incidence of treatment changes due to abnormal blood-test results and, to explore rates of treatment changes due to liver, kidney and haematological blood-test abnormalities in autoimmune rheumatic diseases (AIRD) treated with... Read More about What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline?.

Gut microbial profile is associated with residential settings and not nutritional status in adults in Karnataka, India (2021)
Journal Article

Safety and efficacy of hydrothermal duodenal mucosal resurfacing in patients with type 2 diabetes: the randomised, double-blind, sham-controlled, multicentre REVITA-2 feasibility trial (2021)
Journal Article

Objective: Hydrothermal duodenal mucosal resurfacing (DMR) is a safe, outpatient endoscopic procedure. REVITA-2, a double-blind, superiority RCT, investigates safety and efficacy of DMR using the single catheter Revita system (Revita DMR [catheter an... Read More about Safety and efficacy of hydrothermal duodenal mucosal resurfacing in patients with type 2 diabetes: the randomised, double-blind, sham-controlled, multicentre REVITA-2 feasibility trial.

Serum glucose, lactate dehydrogenase and hypertension are mediators of the 1 effect of body mass index on severity of COVID-19 (2021)
Journal Article

Background: COVID-19 has a broad clinical specturm. We investigated the role of serum markers measured on admission on severity as assessed at discharge and investigated those which relate to the effect of BMI on severity. Methods: Clinical and la... Read More about Serum glucose, lactate dehydrogenase and hypertension are mediators of the 1 effect of body mass index on severity of COVID-19.

Metabolic Imaging in Non-Alcoholic Fatty Liver Disease: Applications of Magnetic Resonance Spectroscopy (2021)
Journal Article

Non-alcoholic fatty liver disease (NAFLD) is poised to dominate the landscape of clinical hepatology in the 21st century. Its complex, interdependent aetiologies, non-linear disease progression and uncertain natural history have presented great chall... Read More about Metabolic Imaging in Non-Alcoholic Fatty Liver Disease: Applications of Magnetic Resonance Spectroscopy.

Evaluating the sensitivity and specificity of promising circulating biomarkers to diagnose liver injury in humans (2021)
Journal Article

Early diagnosis of drug-induced liver injury (DILI) continues to be a major hurdle during drug development and post marketing. The objective of this study was to evaluate the diagnostic performance of promising biomarkers of liver injury - glutamate... Read More about Evaluating the sensitivity and specificity of promising circulating biomarkers to diagnose liver injury in humans.

Long-term outcomes of liver transplant recipients followed up in non-transplant centres: Care closer to home (2021)
Journal Article

Introduction: Increasing rates of liver transplantation and improved outcomes have led to greater numbers of transplant recipients followed up in non-transplant centres. Our aim was to document long-term clinical outcomes of liver transplant recipien... Read More about Long-term outcomes of liver transplant recipients followed up in non-transplant centres: Care closer to home.

MR Measures of Small Bowel Wall T2 Are Associated With Increased Permeability (2020)
Journal Article

Background: Increased small bowel permeability leads to bacterial translocation, associated with significant morbidity and mortality. Biomarkers are needed to evaluate these changes in vivo, stratify an individual's risk, and evaluate the efficacy of... Read More about MR Measures of Small Bowel Wall T2 Are Associated With Increased Permeability.

Non-alcoholic fatty liver disease: Not time for an obituary just yet! (2020)
Journal Article

Genetic Risk Factors in Drug?Induced Liver Injury Due to Isoniazid?Containing Antituberculosis Drug Regimens (2020)
Journal Article

Drug?induced liver injury (DILI) is a complication of treatment with anti?tuberculosis (TB) drugs, especially in isoniazid?containing regimens. To investigate genetic risk factors, we performed a genome?wide association study (GWAS) involving anti?TB... Read More about Genetic Risk Factors in Drug?Induced Liver Injury Due to Isoniazid?Containing Antituberculosis Drug Regimens.

Acceptability of chronic liver disease screening in a UK primary care setting: a qualitative evaluation (2020)
Journal Article

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. OBJECTIVES: The increasing incidence of chronic liver disease (CLD) in the UK may be attributed to a rise in... Read More about Acceptability of chronic liver disease screening in a UK primary care setting: a qualitative evaluation.

Guidelines on the management of ascites in cirrhosis (2020)
Journal Article

The British Society of Gastroenterology in collaboration with British Association for the Study of the Liver has prepared this document. The aim of this guideline is to review and summarise the evidence that guides clinical diagnosis and management o... Read More about Guidelines on the management of ascites in cirrhosis.

In severe alcoholic hepatitis, serum cytokeratin-18 fragments are diagnostic, prognostic and theragnostic biomarkers (2020)
Journal Article

INTRODUCTION: Up to 40% of patients with severe alcoholic hepatitis (AH) die within 6 months of presentation, making prompt diagnosis and appropriate treatment essential. We determined the associations between serum keratin-18 (K18) and histologi... Read More about In severe alcoholic hepatitis, serum cytokeratin-18 fragments are diagnostic, prognostic and theragnostic biomarkers.

Comparison of the reverse bevel versus Franseen type endoscopic ultrasound needle (2020)
Journal Article

BACKGROUND Reverse bevel (RB) needle is widely used for endoscopic ultrasound fine needle biopsy (EUS-FNB). A 3-plane symmetrical needle with Franseen geometry (FG) has recently become available. AIM To compare the clinical efficacy of FG to that... Read More about Comparison of the reverse bevel versus Franseen type endoscopic ultrasound needle.

Role of drugs used for chronic disease management on susceptibility and severity of COVID-19: A large case-control study (2020)
Journal Article

The study aimed to investigate whether specific medications used in the treatment chronic diseases affected either the development and/ or severity of COVID-19 in a cohort of 610 COVID-19 cases and 48,667 population-based controls from Zheijang, Chin... Read More about Role of drugs used for chronic disease management on susceptibility and severity of COVID-19: A large case-control study.

Polygenic architecture informs potential vulnerability to drug-induced liver injury (2020)
Journal Article

Drug-Induced-Liver-Injury (DILI) is a leading cause of termination in drug development programs and removal of drugs from the market, and this is partially due to the inability to identify patients who are at risk1. Here, we developed a polygenic ris... Read More about Polygenic architecture informs potential vulnerability to drug-induced liver injury.