All Outputs (8)

Obesity and type 2 diabetes are important risk factors underlying previously undiagnosed cirrhosis in general practice: a cross-sectional study using Transient Elastography (2017)
Journal Article
Harman, D. J., Ryder, S. D., James, M. W., Wilkes, E. A., Card, T. R., Aithal, G. P., & Guha, I. N. (2018). Obesity and type 2 diabetes are important risk factors underlying previously undiagnosed cirrhosis in general practice: a cross-sectional study using Transient Elastography. Alimentary Pharmacology and Therapeutics, 47(4), 504-515. https://doi.org/10.1111/apt.14463

Background: Rising cirrhosis incidence and mortality in the United Kingdom has been attributed predominantly to excess alcohol consumption. However, metabolic risk factors such as type 2 diabetes and obesity may also be important. Aim: To screen at-... Read More about Obesity and type 2 diabetes are important risk factors underlying previously undiagnosed cirrhosis in general practice: a cross-sectional study using Transient Elastography.

Glycaemic, gastrointestinal and appetite responses to breakfast porridges from ancient cereal grains: a MRI pilot study in healthy humans (2017)
Journal Article
Alyami, J., Ladd, N., Pritchard, S. E., Hoad, C. L., Abdul Sultan, A., Spiller, R. C., …Taylor, M. A. (2017). Glycaemic, gastrointestinal and appetite responses to breakfast porridges from ancient cereal grains: a MRI pilot study in healthy humans. Food Research International, https://doi.org/10.1016/j.foodres.2017.11.071

Cereal grain based porridges are commonly consumed throughout the world. Whilst some data are available for varieties that are popular in the Western world such as oats and rye, other ‘ancient’ grains used in the East and in Africa such as millets ar... Read More about Glycaemic, gastrointestinal and appetite responses to breakfast porridges from ancient cereal grains: a MRI pilot study in healthy humans.

Healthcare costs of transarterial chemoembolization in the treatment of hepatocellular carcinoma (2017)
Journal Article
Fateen, W., Khan, F., O’Neill, R., James, M., Ryder, S., & Aithal, G. (2017). Healthcare costs of transarterial chemoembolization in the treatment of hepatocellular carcinoma. Journal of Hepatocellular Carcinoma, 2017(4), https://doi.org/10.2147/JHC.S144068

Background: A meta-analysis comparing drug-eluting beads transarterial chemoembolization (DEB-TACE) with conventional transarterial chemoembolization (cTACE) has recently been published. On balance, no significant differences were found in terms of o... Read More about Healthcare costs of transarterial chemoembolization in the treatment of hepatocellular carcinoma.

Evaluation of laboratory tests for cirrhosis and for alcohol use, in the context of alcoholic cirrhosis (2017)
Journal Article
Whitfield, J. B., Masson, S., Liangpunsakul, S., Hyman, J., Mueller, S., Aithal, G., …Seth, D. (2018). Evaluation of laboratory tests for cirrhosis and for alcohol use, in the context of alcoholic cirrhosis. Alcohol, 66, 1-7. https://doi.org/10.1016/j.alcohol.2017.07.006

Laboratory tests can play an important role in assessment of alcoholic patients, including for evaluation of liver damage and as markers of alcohol intake. Evidence on test performance should lead to better selection of appropriate tests and improved... Read More about Evaluation of laboratory tests for cirrhosis and for alcohol use, in the context of alcoholic cirrhosis.

Spontaneous central venous thrombosis and shunt occlusion following peritoneovenous shunt placement for intractable ascites (2017)
Journal Article
Hariharan, D., Wilkes, E. A., Aithal, G. P., Travis, S., & Lobo, D. N. (2017). Spontaneous central venous thrombosis and shunt occlusion following peritoneovenous shunt placement for intractable ascites. Annals of The Royal College of Surgeons of England, 99(5), Article e145-e147. https://doi.org/10.1308/rcsann.2017.0058

A 43-year-old man had a peritoneovenous shunt inserted for the treatment of chylous ascites secondary to myelofibrosis. Despite being on anticoagulation for superior mesenteric vein thrombosis, he developed shunt dysfunction within two weeks of inser... Read More about Spontaneous central venous thrombosis and shunt occlusion following peritoneovenous shunt placement for intractable ascites.

Minocycline hepatotoxicity: clinical characterization and identification of HLA-B? 35:02 as a risk factor (2017)
Journal Article
Urban, T. J., Nicoletti, P., Chalasani, N., Serrano, J., Stolz, A., Daly, A. K., …Fontana, R. J. (in press). Minocycline hepatotoxicity: clinical characterization and identification of HLA-B∗ 35:02 as a risk factor. Journal of Hepatology, 67(1), 137-144. https://doi.org/10.1016/j.jhep.2017.03.010

Minocycline hepatotoxicity can present with prominent autoimmune features in previously healthy individuals. The aim of this study was to identify genetic determinants of minocycline DILI in a well-phenotyped cohort of patients. Methods: Caucasian pa... Read More about Minocycline hepatotoxicity: clinical characterization and identification of HLA-B? 35:02 as a risk factor.

Risk of hepatocellular carcinoma among individuals with different aetiologies of cirrhosis: a population-based cohort study (2017)
Journal Article
West, J., Card, T. R., Aithal, G. P., & Fleming, K. M. (2017). Risk of hepatocellular carcinoma among individuals with different aetiologies of cirrhosis: a population-based cohort study. Alimentary Pharmacology and Therapeutics, 45(7), 983-990. https://doi.org/10.1111/apt.13961

Background: Among patients with cirrhosis, only those determined to be at risk for hepatocellular carcinoma (HCC) should undergo surveillance. However, little is known about how different aetiologies of cirrhosis affect risk for HCC. Aim: To quantif... Read More about Risk of hepatocellular carcinoma among individuals with different aetiologies of cirrhosis: a population-based cohort study.

Prevalence of clinically significant liver disease within the general population, as defined by non-invasive markers of liver fibrosis: a systematic review (2017)
Journal Article
Harris, R., Harman, D. J., Card, T. R., Aithal, G. P., & Guha, I. N. (2017). Prevalence of clinically significant liver disease within the general population, as defined by non-invasive markers of liver fibrosis: a systematic review. The Lancet Gastroenterology & Hepatology, 2(4), 288-297. https://doi.org/10.1016/S2468-1253%2816%2930205-9

As of 2016, there is no evidence-based pathway to stratify the risk of chronic liver disease in a general population setting. Non-invasive tests of liver fibrosis might provide a mechanism for earlier diagnosis. These tests have been extensively vali... Read More about Prevalence of clinically significant liver disease within the general population, as defined by non-invasive markers of liver fibrosis: a systematic review.