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Incidence and etiology of drug-induced liver injury in mainland China (2019)
Journal Article
Shen, T., Liu, Y., Shang, J., Xie, Q., Li, J., Yan, M., …Chen, C. (2019). Incidence and etiology of drug-induced liver injury in mainland China. Gastroenterology, doi:10.1053/j.gastro.2019.02.002

Background & Aims: We performed a nationwide, retrospective study to determine the incidence and causes of drug-induced liver injury (DILI) in mainland China. Methods: We collected data on a total of 25,927 confirmed DILI cases, hospitalized from... Read More

Validation of a model for identification of patients with compensated cirrhosis at high risk of decompensation (2019)
Journal Article
Guha, I., Harris, R., Berhane, S., Dillon, A., Coffey, L., James, M., …Johnson, P. (2019). Validation of a model for identification of patients with compensated cirrhosis at high risk of decompensation. Clinical Gastroenterology and Hepatology, doi:10.1016/j.cgh.2019.01.042

Background & Aims: It is important to rapidly identify patients with advanced liver disease. Routine tests to assess liver function and fibrosis provide data that can be used to determine patients’ prognoses. We tested the validated the ability of co... Read More

Identification of a PTPN22 missense variant as a general genetic risk factor for drug-induced liver injury (2019)
Journal Article
Cirulli, E. T., Nicoletti, P., Abramson, K., Andrade, R. J., Bjornsson, E. S., Chalasani, N., …Watkins, P. B. (in press). Identification of a PTPN22 missense variant as a general genetic risk factor for drug-induced liver injury. Gastroenterology,

Background & Aims: We performed genetic analyses of a multiethnic cohort of patients with idiosyncratic drug-induced liver injury (DILI) to identify variants associated with susceptibility. Methods: We performed a genome-wide association study of... Read More

Drug-induced injury due to flucloxacillin: relevance of multiple HLA alleles (2018)
Journal Article
Nicoletti, P., Aithal, G. P., Chamberlain, T. C., Coulthard, S., Alshabeeb, M., Grove, J. I., …Daly, A. K. (in press). Drug-induced injury due to flucloxacillin: relevance of multiple HLA alleles. CPT: Pharmacometrics and Systems Pharmacology,

Some patients prescribed flucloxacillin (~0.01%) develop drug-induced liver injury (DILI). HLAB*57:01 is an established genetic risk factor for flucloxacillin DILI. To consolidate this finding, identify additional genetic factors and assess relevance... Read More

MRI assessment of altered dynamic changes in liver haemodynamics following a meal challenge in compensated cirrhosis (2018)
Journal Article
Cox, E. F., Palaniyappan, N., Aithal, G. P., Guha, I. N., & Francis, S. T. (2018). MRI assessment of altered dynamic changes in liver haemodynamics following a meal challenge in compensated cirrhosis. European Radiology Experimental, 2, doi:10.1186/s41747-018-0056-3. ISSN 2509-9280

Background: To use magnetic resonance imaging (MRI) to dynamically assess postprandial changes in hepatic and collateral blood flow, liver perfusion and oxygenation in healthy participants and patients with liver disease with compensated cirrhosis (C... Read More

ADAPT: an algorithm incorporating PRO-C3 accurately identifies patients with NAFLD and advanced fibrosis (2018)
Journal Article
Daniels, S. J., Leeming, D. J., Eslam, M., Hashem, A. M., Nielsen, M. J., Krag, A., …George, J. (in press). ADAPT: an algorithm incorporating PRO-C3 accurately identifies patients with NAFLD and advanced fibrosis. Hepatology, ISSN 0270-9139

Background and Aim: Given the high global prevalence of non-alcoholic fatty liver disease (NAFLD), the need for relevant non-invasive biomarkers and algorithms to accurately stage disease severity is a critical unmet medical need. Identifying those w... Read More

Multi organ assessment of compensated cirrhosis patients using quantitative magnetic resonance imaging (2018)
Journal Article
Bradley, C. R., Cox, E. F., Scott, R. A., James, M. W., Kaye, P., Aithal, G. P., …Guha, I. N. (in press). Multi organ assessment of compensated cirrhosis patients using quantitative magnetic resonance imaging. Journal of Hepatology, doi:10.1016/j.jhep.2018.05.037. ISSN 0168-8278

Background and Aims: Advancing liver disease results in deleterious changes in a number of critical organs. The ability to measure structure, blood flow and tissue perfusion within multiple organs in a single scan has implications for determining the... Read More

Pharmacogenomics of drug-induced liver injury (DILI): molecular biology to clinical applications (2018)
Journal Article
Kaliyaperumal, K., Grove, J. I., Delahay, R. M., Griffiths, W. J., Duckworth, A., & Aithal, G. P. (in press). Pharmacogenomics of drug-induced liver injury (DILI): molecular biology to clinical applications. Journal of Hepatology, doi:10.1016/j.jhep.2018.05.013. ISSN 0168-8278

A number of drug-specific and host-related factors contribute to the development of drug-induced liver injury (DILI). Investigations focused on genetic susceptibility to DILI have advanced our understanding of the pathogenesis of this rare, yet poten... Read More

The XL probe: a luxury or a necessity? risk stratification in an obese community cohort using transient elastography (2018)
Journal Article
Harris, R., Card, T. R., Delahooke, T., Aithal, G. P., & Guha, I. N. (2018). The XL probe: a luxury or a necessity? risk stratification in an obese community cohort using transient elastography. United European Gastroenterology Journal, doi:10.1177/2050640618772944. ISSN 2050-6406

Background: Transient elastography is a non-invasive tool which can stratify patients at risk of chronic liver disease. However, a raised body mass index has been independently associated with a failed or unreliable examination. Objective: The pur... Read More

A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis (2018)
Journal Article
treatment of nonalcoholic steatohepatitis with fibrosis. Hepatology, 67(5), doi:10.1002/hep.29477. ISSN 0270-9139

The aim of this study was to evaluate cenicriviroc (CVC), a dual antagonist of C-C chemokine receptor types 2 and 5, for treatment of nonalcoholic steatohepatitis (NASH) with liver fibrosis. A randomized, double-blind, multinational phase 2b study e... Read More