Endothelium and Subendothelial Matrix Mechanics Modulate Cancer Cell Transendothelial Migration

Javanmardi, Yousef; Agrawal, Ayushi; Malandrino, Andrea; Lasli, Soufian; Chen, Michelle; Shahreza, Somayeh; Serwinski, Bianca; Cammoun, Leila; Li, Ran; Jorfi, Mehdi; Djordjevic, Boris; Szita, Nicolas; Spill, Fabian; Bertazzo, Sergio; Sheridan, Graham K; Shenoy, Vivek; Calvo, Fernando; Kamm, Roger

doi:10.1002/advs.202206554

All Outputs (3)

Emergent mechanical control of vascular morphogenesis (2023)
Journal Article

Vascularization is driven by morphogen signals and mechanical cues that coordinately regulate cellular force generation, migration, and shape change to sculpt the developing vascular network. However, it remains unclear whether developing vasculature... Read More about Emergent mechanical control of vascular morphogenesis.

Hippocampus of the APP NL–G–F mouse model of Alzheimer’s disease exhibits region-specific tissue softening concomitant with elevated astrogliosis (2023)
Journal Article

Widespread neurodegeneration, enlargement of cerebral ventricles, and atrophy of cortical and hippocampal brain structures are classic hallmarks of Alzheimer’s disease (AD). Prominent macroscopic disturbances to the cytoarchitecture of the AD brain o... Read More about Hippocampus of the APP NL–G–F mouse model of Alzheimer’s disease exhibits region-specific tissue softening concomitant with elevated astrogliosis.

Endothelium and Subendothelial Matrix Mechanics Modulate Cancer Cell Transendothelial Migration (2023)
Journal Article

Cancer cell extravasation, a key step in the metastatic cascade, involves cancer cell arrest on the endothelium, transendothelial migration (TEM), followed by the invasion into the subendothelial extracellular matrix (ECM) of distant tissues. While c... Read More about Endothelium and Subendothelial Matrix Mechanics Modulate Cancer Cell Transendothelial Migration.