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All Outputs (34)

A meta-analysis and systematic review of the use of transition tools for patients transitioning from paediatric to adult rheumatology services (2024)
Journal Article
Griffin, K., Pearce, F., & Packham, J. (2024). A meta-analysis and systematic review of the use of transition tools for patients transitioning from paediatric to adult rheumatology services. Rheumatology Advances in Practice, 8(4), Article rkae130. https://doi.org/10.1093/rap/rkae130

Introduction: Transition from paediatric to adult care can be challenging, but transition tools are designed to increase successful rates of transfer.
Objectives: Conduct a meta-analysis and systematic review into the use of transition tools on tran... Read More about A meta-analysis and systematic review of the use of transition tools for patients transitioning from paediatric to adult rheumatology services.

Prevalence, Incidence, and Mortality of Raynaud’s phenomenon, Sjögren’s syndrome, and scleroderma: an umbrella review of systematic reviews (2024)
Journal Article
Chen, A., Lax, S. J., Grainge, M. J., Lanyon, P. C., & Pearce, F. A. (2024). Prevalence, Incidence, and Mortality of Raynaud’s phenomenon, Sjögren’s syndrome, and scleroderma: an umbrella review of systematic reviews. Rheumatology Advances in Practice, 8(3), Article rkae086. https://doi.org/10.1093/rap/rkae086

Objectives:

To comprehensively review systematic reviews of prevalence, incidence, and mortality of Raynaud’s, Sjögren’s, and Scleroderma, and to identify any research gaps.

Methods:

An umbrella review of English language systematic review... Read More about Prevalence, Incidence, and Mortality of Raynaud’s phenomenon, Sjögren’s syndrome, and scleroderma: an umbrella review of systematic reviews.

Antibody response to four doses of SARS-CoV-2 vaccine in rare autoimmune rheumatic diseases: an observational study (2023)
Journal Article
Gumber, L., Jackson, H., Gomez, N., Hopkins, G., Tucis, D., Chakravorty, M., Tighe, P., Grainge, M. J., Rutter, M., Ferraro, A., Power, S., Pradère, M.-J., Lanyon, P. C., Pearce, F. A., & Fairclough, L. (2023). Antibody response to four doses of SARS-CoV-2 vaccine in rare autoimmune rheumatic diseases: an observational study. Rheumatology Advances in Practice, 7(3), Article rkad097. https://doi.org/10.1093/rap/rkad097

Objective: Antibody responses to coronavirus disease 2019 (COVID-19) vaccines are reduced among immunocompromised patients but are not well quantified among people with rare disease. We conducted an observational study to evaluate the antibody respon... Read More about Antibody response to four doses of SARS-CoV-2 vaccine in rare autoimmune rheumatic diseases: an observational study.

Long-term outcomes (beyond 5 years) of liver transplant recipients--a transatlantic multicenter study (2023)
Journal Article
Palaniyappan, N., Peach, E., Pearce, F., Dhaliwal, A., Campos-Varela, I., Cant, M. R., Dopazo, C., Trotter, J., Divani-Patel, S., Hatta, A. A., Hopkins, L., Testa, G., Bilbao, A., Kasmani, Z., Faloon, S., Mirza, D. F., Klintmalm, G. B., Bilbao, I., Asrani, S. K., Rajoriya, N., & Aravinthan, A. D. (2024). Long-term outcomes (beyond 5 years) of liver transplant recipients--a transatlantic multicenter study. Liver Transplantation, 30(2), 170-181. https://doi.org/10.1097/LVT.0000000000000244

The long-term (>5y) outcomes following liver transplantation (LT) have not been extensively reported. The aim was to evaluate outcomes of LT recipients who have survived the first 5 years. A multicenter retrospective analysis of prospectively collect... Read More about Long-term outcomes (beyond 5 years) of liver transplant recipients--a transatlantic multicenter study.

Long-term outcomes (beyond 5 years) of liver transplant recipients - a transatlantic multicentre study (2023)
Journal Article
Palaniyappan, N., Peach, E., Pearce, F., Dhaliwal, A., Campos-Varela, I., Cant, M. R., Dopazo, C., Trotter, J., Divani-Patel, S., AZ Hatta, A., Hopkins, L., Testa, G., Bilbao, A., Kasmani, Z., Faloon, S., Mirza, D. F., Klintmalm, G. B., Bilbao, I., Asrani, S. K., Rajoriya, N., & Aravinthan, A. D. (2024). Long-term outcomes (beyond 5 years) of liver transplant recipients - a transatlantic multicentre study. Liver Transplantation, 30(2), 170-181. https://doi.org/10.1097/LVT.0000000000000244

The long-term (>5 year) outcomes following liver transplantation (LT) have not been extensively reported. The aim was to evaluate outcomes of LT recipients who have survived the first 5 years. A
multicentre retrospective analysis of prospectively... Read More about Long-term outcomes (beyond 5 years) of liver transplant recipients - a transatlantic multicentre study.

Antibody prevalence after three or more COVID-19 vaccine doses in individuals who are immunosuppressed in the UK: a cross-sectional study from MELODY (2023)
Journal Article
Pearce, F. A., Lim, S. H., Bythell, M., Lanyon, P., Hogg, R., Taylor, A., Powter, G., Cooke, G. S., Ward, H., Chilcot, J., Thomas, H., Mumford, L., McAdoo, S. P., Pettigrew, G. J., Lightstone, L., & Willicombe, M. (2023). Antibody prevalence after three or more COVID-19 vaccine doses in individuals who are immunosuppressed in the UK: a cross-sectional study from MELODY. The Lancet Rheumatology, 5(8), E461-E473. https://doi.org/10.1016/S2665-9913%2823%2900160-1

Background: In the UK, additional COVID-19 vaccine booster doses and treatments are offered to people who are immunosuppressed to protect against severe COVID-19, but how best to choose the individuals that receive these vaccine booster doses and tre... Read More about Antibody prevalence after three or more COVID-19 vaccine doses in individuals who are immunosuppressed in the UK: a cross-sectional study from MELODY.

COVID-19 infection, admission and death and the impact of corticosteroids amongst people with rare autoimmune rheumatic disease during the second wave of covid-19 in England: results from the RECORDER Project (2023)
Journal Article
Rutter, M., Lanyon, P. C., Grainge, M. J., Hubbard, R., Bythell, M., Stilwell, P., Aston, J., McPhail, S., Stevens, S., & Pearce, F. A. (2023). COVID-19 infection, admission and death and the impact of corticosteroids amongst people with rare autoimmune rheumatic disease during the second wave of covid-19 in England: results from the RECORDER Project. Rheumatology, 62(12), 3828-3837. https://doi.org/10.1093/rheumatology/kead150

Objectives
To calculate the rates of COVID-19 infection and COVID-19-related death among people with rare autoimmune rheumatic diseases (RAIRD) during the second wave of the COVID-19 pandemic in England, and describe the impact of corticosteroids on... Read More about COVID-19 infection, admission and death and the impact of corticosteroids amongst people with rare autoimmune rheumatic disease during the second wave of covid-19 in England: results from the RECORDER Project.

The incidence of Kawasaki disease using hospital admissions data for England 2006-2021 (2023)
Journal Article
Odingo, M., Rutter, M., Bowley, J., Peach, E. J., Lanyon, P. C., Grainge, M. J., Stillwell, P., McPhail, S., Bythell, M., Aston, J., Stevens, S., McCormack, R., Brogan, P., & Pearce, F. A. (2023). The incidence of Kawasaki disease using hospital admissions data for England 2006-2021. Rheumatology, 62(9), 3117–3125. https://doi.org/10.1093/rheumatology/kead051

Objective: To describe the incidence of Kawasaki Disease (kDa) between 2006 and 2021 in England. Methods: We identified all cases in hospital episode statistics with an ICD-10 diagnostic code M303 (for kDa) between 1 April 2006 and 31 March 2021. We... Read More about The incidence of Kawasaki disease using hospital admissions data for England 2006-2021.

Validation of methods to identify people with idiopathic inflammatory myopathies using hospital episode statistics (2022)
Journal Article
Hannah, J., Gordon, P., Galloway, J., Rutter, M., Peach, E., Rooney, M., Stilwell, P., Grainge, M., Lanyon, P., Bythell, M., & Pearce, F. (2022). Validation of methods to identify people with idiopathic inflammatory myopathies using hospital episode statistics. Rheumatology Advances in Practice, 6(3), Article rkac102. https://doi.org/10.1093/rap/rkac102

Objective: Hospital episode statistics (HES) are routinely recorded at every hospital admission within the National Health Service (NHS) in England. This study validates diagnostic ICD-10 codes within HES as a method of identifying cases of idiopathi... Read More about Validation of methods to identify people with idiopathic inflammatory myopathies using hospital episode statistics.

Humoral and cellular immunity in patients with rare autoimmune rheumatic diseases following SARS-CoV-2 vaccination (2022)
Journal Article
Gumber, L., Gomez, N., Hopkins, G., Tucis, D., Bartlett, L., Ayling, K., Vedhara, K., Steers, G., Chakravorty, M., Rutter, M., Jackson, H., Tighe, P., Ferraro, A., Power, S., Pradère, M.-J., Onion, D., Lanyon, P. C., Pearce, F. A., & Fairclough, L. (2023). Humoral and cellular immunity in patients with rare autoimmune rheumatic diseases following SARS-CoV-2 vaccination. Rheumatology, 62(6), 2294-2303. https://doi.org/10.1093/rheumatology/keac574

Objectives: COVID-19 vaccine responses in rare autoimmune rheumatic diseases (RAIRD) remain poorly understood, in particular there is little known about whether people develop effective T-cell responses. We conducted a prospective cohort study to eva... Read More about Humoral and cellular immunity in patients with rare autoimmune rheumatic diseases following SARS-CoV-2 vaccination.

COVID-19 infection and hospitalization risk according to vaccination status and DMARD treatment in patients with rheumatoid arthritis (2022)
Journal Article
Cordtz, R., Kristensen, S., Westermann, R., Duch, K., Pearce, F., Lindhardsen, J., Torp-Pedersen, C., Andersen, M. P., & Dreyer, L. (2023). COVID-19 infection and hospitalization risk according to vaccination status and DMARD treatment in patients with rheumatoid arthritis. Rheumatology, 62(1), 77-88. https://doi.org/10.1093/rheumatology/keac241

Objectives: The objectives of this study were to investigate the incidence of COVID-19 hospitalization in unvaccinated and vaccinated patients with RA compared with matched controls, and in patients with RA according to DMARD treatment.

Methods: T... Read More about COVID-19 infection and hospitalization risk according to vaccination status and DMARD treatment in patients with rheumatoid arthritis.

COVID-19 infection, admission and death among people with rare autoimmune rheumatic disease in England: results from the RECORDER project (2021)
Journal Article
Rutter, M., Lanyon, P. C., Grainge, M. J., Hubbard, R., Peach, E., Bythell, M., Stilwell, P., Aston, J., Stevens, S., & Pearce, F. A. (2022). COVID-19 infection, admission and death among people with rare autoimmune rheumatic disease in England: results from the RECORDER project. Rheumatology, 61(8), 3161-3171. https://doi.org/10.1093/rheumatology/keab794

Objectives: To calculate the rates of COVID-19 infection and COVID-19-related death among people with rare autoimmune rheumatic diseases (RAIRD) during the first wave of the COVID-19 pandemic in England compared to the general population.

Methods... Read More about COVID-19 infection, admission and death among people with rare autoimmune rheumatic disease in England: results from the RECORDER project.

Estimating the clinical prevalence of Wilson’s disease in the UK (2021)
Journal Article
Wijayasiri, P., Hayre, J., Nicholson, E. S., Kaye, P., Wilkes, E. A., Evans, J., Aithal, G. P., Jones, G., Pearce, F., & Aravinthan, A. D. (2021). Estimating the clinical prevalence of Wilson’s disease in the UK. JHEP Reports, 3(5), Article 100329. https://doi.org/10.1016/j.jhepr.2021.100329

Background and Aim
The clinical prevalence of Wilson’s disease (WD) in the UK remains unknown. The estimated genetic prevalence in the UK, 142/million, is higher than the clinical prevalence (15/million) reported in other European studies. The aim o... Read More about Estimating the clinical prevalence of Wilson’s disease in the UK.

A Systematic Review and Meta-Analysis of the Incidence Rate of Takayasu Arteritis (2021)
Journal Article
Grainge, M. J., Rutter, M., Lanyon, P. C., Pearce, F. A., Bowley, J., & Claringburn, T. (2021). A Systematic Review and Meta-Analysis of the Incidence Rate of Takayasu Arteritis. Rheumatology, 60(11), 4982-4990. https://doi.org/10.1093/rheumatology/keab406

Objectives:
Takayasu arteritis (TAK), is a rare autoimmune rheumatic disease causing large vessel vasculitis. Onset is typically between the ages of 20-30. It is associated with substantial morbidity and mortality, notably due to its effects on the... Read More about A Systematic Review and Meta-Analysis of the Incidence Rate of Takayasu Arteritis.

Opioids and the risk of fracture: a self-controlled case series study in the Clinical Practice Research Datalink (2021)
Journal Article
Peach, E., Pearce, F., Gibson, J., Cooper, A., Chen, L.-C., & Knaggs, R. (2021). Opioids and the risk of fracture: a self-controlled case series study in the Clinical Practice Research Datalink. American Journal of Epidemiology, 190(7), 1324-1331. https://doi.org/10.1093/aje/kwab042

Self-controlled study designs can be used to assess the association between exposures and acute outcomes while controlling for important confounders. Using routinely collected health data, a self-controlled case series design was used to investigate... Read More about Opioids and the risk of fracture: a self-controlled case series study in the Clinical Practice Research Datalink.

Opioids and the risk of fracture: a self-controlled case series study in the Clinical Practice Research Datalink (2021)
Journal Article
Peach, E. J., Pearce, F. A., Gibson, J., Andrew J. Cooper, A. J., Chen, L.-C., & Knaggs, R. D. (2021). Opioids and the risk of fracture: a self-controlled case series study in the Clinical Practice Research Datalink. American Journal of Epidemiology, 190(7), 1324-1331. https://doi.org/10.1093/aje/kwab042

Self-controlled study designs can be used to assess the association between exposures and acute outcomes while controlling for important confounders. Using routinely collected health data, a self-controlled case series design was used to investigate... Read More about Opioids and the risk of fracture: a self-controlled case series study in the Clinical Practice Research Datalink.

Worldwide relative smoking prevalence among people living with and without HIV: a systematic review and meta-analysis (2021)
Journal Article
Johnston, P. I., Wright, S. W., Orr, M., Pearce, F. A., Stevens, J. W., Hubbard, R. B., & Collini, P. J. (2021). Worldwide relative smoking prevalence among people living with and without HIV: a systematic review and meta-analysis. AIDS, 35(6), 957-970. https://doi.org/10.1097/QAD.0000000000002815

Objective and design: People living with HIV (PLH) suffer disproportionately from the chronic diseases exacerbated by smoking tobacco. We performed a systematic review and meta-analysis to establish the relative prevalence of smoking among PLH.

M... Read More about Worldwide relative smoking prevalence among people living with and without HIV: a systematic review and meta-analysis.

BSR guideline on the management of adults with systemic lupus erythematosus (SLE) 2018: Baseline multi-centre audit in the UK (2020)
Journal Article
Pearce, F. A., Rutter, M., Sandhu, R., Batten, R. L., Garner, R., Little, J., Narayan, N., Sharp, C. A., Bruce, I. N., Erb, N., Griffiths, B., Guest, H., Macphie, E., Packham, J., Hiley, C., Obrenovic, K., Rivett, A., Gordon, C., & Lanyon, P. C. (2021). BSR guideline on the management of adults with systemic lupus erythematosus (SLE) 2018: Baseline multi-centre audit in the UK. Rheumatology, 60(3), 1480-1490. https://doi.org/10.1093/rheumatology/keaa759

Objectives: To assess the baseline care provided to patients with SLE attending UK Rheumatology units, audited against standards derived from the recently published BSR guideline for the management of adults with SLE, the NICE technology appraisal fo... Read More about BSR guideline on the management of adults with systemic lupus erythematosus (SLE) 2018: Baseline multi-centre audit in the UK.

Risk of death among people with rare autoimmune diseases compared with the general population in England during the 2020 COVID-19 pandemic (2020)
Journal Article
Peach, E., Rutter, M., Lanyon, P., Grainge, M. J., Hubbard, R., Aston, J., Bythell, M., Stevens, S., & Pearce, F. (2021). Risk of death among people with rare autoimmune diseases compared with the general population in England during the 2020 COVID-19 pandemic. Rheumatology, 60(4), 1902–1909. https://doi.org/10.1093/rheumatology/keaa855

Objectives: To quantify the risk of death among people with rare autoimmune rheumatic diseases (RAIRD) during the UK 2020 COVID-19 pandemic compared with the general population, and compared with their pre-COVID risk. Methods: We conducted a cohort s... Read More about Risk of death among people with rare autoimmune diseases compared with the general population in England during the 2020 COVID-19 pandemic.