Discovery of synergistic material-topography combinations to achieve immunomodulatory osteoinductive biomaterials using a novel in vitro screening method: The ChemoTopoChip

Burroughs, Laurence; Amer, Mahetab; Vassey, Matthew; Koch, Britta; Figueredo, Grazziela; Mukonoweshuro, Blessing; Mikulskis, Paulius; Vasilevich, Aliaksei; Vermeulen, Steven; Dryden, Ian L; Winkler, David A; Ghaemmaghami, Amir M; Rose, Felicity R. A. J.; de Boer, Jan; Alexander, Morgan R

doi:10.1016/j.biomaterials.2021.120740

All Outputs (6)

Ink-jet 3D printing as a strategy for developing bespoke non-eluting biofilm resistant medical devices (2021)
Journal Article

Chronic infection as a result of bacterial biofilm formation on implanted medical devices is a major global healthcare problem requiring new biocompatible, biofilm-resistant materials. Here we demonstrate how bespoke devices can be manufactured throu... Read More about Ink-jet 3D printing as a strategy for developing bespoke non-eluting biofilm resistant medical devices.

Bespoke 3D-Printed Polydrug Implants Created via Microstructural Control of Oligomers (2021)
Journal Article

Controlling the microstructure of materials by means of phase separation is a versatile tool for optimizing material properties. Phase separation has been exploited to fabricate intricate microstructures in many fields including cell biology, tissue... Read More about Bespoke 3D-Printed Polydrug Implants Created via Microstructural Control of Oligomers.

Droplet Microfluidic Optimisation Using Micropipette Characterisation of Bio-Instructive Polymeric Surfactants (2021)
Journal Article

Droplet microfluidics can produce highly tailored microparticles whilst retaining monodispersity. However, these systems often require lengthy optimisation, commonly based on a trial-and-error approach, particularly when using bio-instructive, polyme... Read More about Droplet Microfluidic Optimisation Using Micropipette Characterisation of Bio-Instructive Polymeric Surfactants.

Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices (2021)
Journal Article

As the understanding of disease grows, so does the opportunity for personalization of therapies targeted to the needs of the individual. To bring about a step change in the personalization of medical devices it is shown that multi-material inkjet-bas... Read More about Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices.

Mixed polymer and bioconjugate core/shell electrospun fibres for biphasic protein release (2021)
Journal Article

Effective regenerative medicine requires delivery systems which can release multiple components at appropriate levels and at different phases of tissue growth and repair. However, there are few biomaterials and encapsulation techniques that are fully... Read More about Mixed polymer and bioconjugate core/shell electrospun fibres for biphasic protein release.

Discovery of synergistic material-topography combinations to achieve immunomodulatory osteoinductive biomaterials using a novel in vitro screening method: The ChemoTopoChip (2021)
Journal Article

© 2021 The Authors Human mesenchymal stem cells (hMSCs) are widely represented in regenerative medicine clinical strategies due to their compatibility with autologous implantation. Effective bone regeneration involves crosstalk between macrophages an... Read More about Discovery of synergistic material-topography combinations to achieve immunomodulatory osteoinductive biomaterials using a novel in vitro screening method: The ChemoTopoChip.