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Droplet Microfluidic Optimisation Using Micropipette Characterisation of Bio-Instructive Polymeric Surfactants

Henshaw, Charlotte A.; Dundas, Adam A.; Cuzzucoli Crucitti, Valentina; Alexander, Morgan R.; Wildman, Ricky; Rose, Felicity R. A. J.; Irvine, Derek J.; Williams, Philip M.

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Authors

Charlotte A. Henshaw

ADAM DUNDAS ADAM.DUNDAS1@NOTTINGHAM.AC.UK
Assistant Professor

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MORGAN ALEXANDER MORGAN.ALEXANDER@NOTTINGHAM.AC.UK
Professor of Biomedical Surfaces

RICKY WILDMAN RICKY.WILDMAN@NOTTINGHAM.AC.UK
Professor of Multiphase Flow and Mechanics

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FELICITY ROSE FELICITY.ROSE@NOTTINGHAM.AC.UK
Professor of Biomaterials and Tissue Engineering

DEREK IRVINE derek.irvine@nottingham.ac.uk
Professor of Materials Chemistry

PHIL WILLIAMS PHIL.WILLIAMS@NOTTINGHAM.AC.UK
Professor of Biophysics



Abstract

Droplet microfluidics can produce highly tailored microparticles whilst retaining monodispersity. However, these systems often require lengthy optimisation, commonly based on a trial-and-error approach, particularly when using bio-instructive, polymeric surfactants. Here, micropipette manipulation methods were used to optimise the concentration of bespoke polymeric surfactants to produce biodegradable (poly(d,l-lactic acid) (PDLLA)) microparticles with unique, bio-instructive surface chemistries. The effect of these three-dimensional surfactants on the interfacial tension of the system was analysed. It was determined that to provide adequate stabilisation, a low level (0.1% (w/v)) of poly(vinyl acetate-co-alcohol) (PVA) was required. Optimisation of the PVA concentration was informed by micropipette manipulation. As a result, successful, monodisperse particles were produced that maintained the desired bio-instructive surface chemistry.

Citation

Henshaw, C. A., Dundas, A. A., Cuzzucoli Crucitti, V., Alexander, M. R., Wildman, R., Rose, F. R. A. J., …Williams, P. M. (2021). Droplet Microfluidic Optimisation Using Micropipette Characterisation of Bio-Instructive Polymeric Surfactants. Molecules, 26(11), Article 3302. https://doi.org/10.3390/molecules26113302

Journal Article Type Article
Acceptance Date May 27, 2021
Online Publication Date May 31, 2021
Publication Date May 31, 2021
Deposit Date Jul 2, 2021
Publicly Available Date Mar 29, 2024
Journal Molecules
Electronic ISSN 1420-3049
Peer Reviewed Peer Reviewed
Volume 26
Issue 11
Article Number 3302
DOI https://doi.org/10.3390/molecules26113302
Public URL https://nottingham-repository.worktribe.com/output/5692847
Publisher URL https://www.mdpi.com/1420-3049/26/11/3302

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