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All Outputs (18)

On the phase space structure of IP3 induced Ca2+ signalling and concepts for predictive modeling (2018)
Journal Article
Falcke, M., Moein, M., Tilunaite, A., Thul, R., & Skupin, A. (2018). On the phase space structure of IP3 induced Ca2+ signalling and concepts for predictive modeling. Chaos, 28(4), Article 045115. https://doi.org/10.1063/1.5021073

The correspondence between mathematical structures and experimental systems is the basis of the generalizability of results found with specific systems, and is the basis of the predictive power of theoretical physics. While physicists have confidence... Read More about On the phase space structure of IP3 induced Ca2+ signalling and concepts for predictive modeling.

Bread stories: understanding the drivers of bread consumption for digital food customisation (2017)
Presentation / Conference Contribution
Pantidi, N., Selinas, P., Flintham, M., Baurley, S., & Rodden, T. (2017). Bread stories: understanding the drivers of bread consumption for digital food customisation.

Consumer demand for food that satisfies specific needs rather than generic mass produced food is growing. In response, the food industry is actively investigating techniques for efficient and comprehensive food customisation. Digital approaches to fo... Read More about Bread stories: understanding the drivers of bread consumption for digital food customisation.

The portormin (dunbeath) runestone (2016)
Journal Article
Findell, M. (2016). The portormin (dunbeath) runestone. Futhark: International Journal of Runic Studies, 6, 153-170

A stone with a short runic inscription was discovered on the beach at Portormin Harbour in Dunbeath, Caithness, in 1996. The find attracted some press attention at the time, but has been largely ignored by the runological com­mu­nity amid doubts over... Read More about The portormin (dunbeath) runestone.

Run spot run: capturing and tagging footage of a race by crowds of spectators (2015)
Presentation / Conference Contribution
Flintham, M. D., Velt, R., Wilson, M. L., Anstead, E. J., Benford, S., Brown, A., …Sprinks, J. (2015). Run spot run: capturing and tagging footage of a race by crowds of spectators. In CHI '15: Proceedings of the 33rd Annual ACM Conference on Human Factors in Computing Systems (747-756). https://doi.org/10.1145/2702123.2702463

There has been a massive growth in the number of people who film and upload amateur footage of events to services such as Facebook and Youtube, or even stream live to services such as LiveStream. We present an exploratory study that investigates the... Read More about Run spot run: capturing and tagging footage of a race by crowds of spectators.

Linguistic variation in early Anglo-Saxon England (2015)
Book Chapter
Findell, M. (2015). Linguistic variation in early Anglo-Saxon England. In R. Cohen, J. Story, & N. Moon (Eds.), The impact of diasporas. Oxford Diasporas Programme & The Impact of Diasporas on the Making of Britain: Evidence, Memories, Inventions

The Malthusian Paradox: performance in an alternate reality game (2014)
Journal Article
Evans, E., Flintham, M., & Martindale, S. (2014). The Malthusian Paradox: performance in an alternate reality game. Personal and Ubiquitous Computing, 18(7), https://doi.org/10.1007/s00779-014-0762-7

The Malthusian Paradox is a transmedia alternate reality game (ARG) created by artists Dominic Shaw and Adam Sporne played by 300 participants over three months. We explore the design of the game, which cast players as agents of a radical organisatio... Read More about The Malthusian Paradox: performance in an alternate reality game.

Fundamental properties of Ca²⁺ signals (2011)
Journal Article
Thurley, K., Skupin, A., Thul, R., & Falcke, M. (2011). Fundamental properties of Ca²⁺ signals. BBA - General Subjects, 1820(8), https://doi.org/10.1016/j.bbagen.2011.10.007

Background
Ca²⁺ is a ubiquitous and versatile second messenger that transmits information through changes of the cytosolic Ca²⁺ concentration. Recent investigations changed basic ideas on the dynamic character of Ca²⁺ signals and challenge tradition... Read More about Fundamental properties of Ca²⁺ signals.

Cardiac cell modelling: observations from the heart of the cardiac physiome project (2011)
Journal Article
Fink, M., Niederer, S. A., Cherry, E. M., Fenton, F. H., Koivumäki, J. T., Seemann, G., …Smith, N. P. (2011). Cardiac cell modelling: observations from the heart of the cardiac physiome project. Progress in Biophysics and Molecular Biology, 104(1-3), https://doi.org/10.1016/j.pbiomolbio.2010.03.002

In this manuscript we review the state of cardiac cell modelling in the context of international initiatives such as the IUPS Physiome and Virtual Physiological Human Projects, which aim to integrate computational models across scales and physics. In... Read More about Cardiac cell modelling: observations from the heart of the cardiac physiome project.

Towards a predictive model of Ca²⁺ puffs (2009)
Journal Article
Thul, R., Thurley, K., & Falcke, M. (2009). Towards a predictive model of Ca²⁺ puffs. Chaos, 19, https://doi.org/10.1063/1.3183809

We investigate key characteristics of Ca²⁺ puffs in deterministic and stochastic frameworks that all incorporate the cellular morphology of IP[subscript]3 receptor channel clusters. In a first step, we numerically study Ca²⁺ liberation in a three dim... Read More about Towards a predictive model of Ca²⁺ puffs.

Waiting time distributions for clusters of complex molecules (2007)
Journal Article
Thul, R., & Falcke, M. (2007). Waiting time distributions for clusters of complex molecules. EPL, 79(3), https://doi.org/10.1209/0295-5075/79/38003

Waiting time distributions are in the core of theories for a large variety of subjects ranging from the analysis of patch clamp records to stochastic excitable systems. Here, we present a novel exact method for the calculation of waiting time distrib... Read More about Waiting time distributions for clusters of complex molecules.

Building oscillations bottom up: Elemental time scales of intracellular calcium dynamics (2007)
Book Chapter
Thul, R., & Falcke, M. (2007). Building oscillations bottom up: Elemental time scales of intracellular calcium dynamics. In L. Schimansky-Geier, B. Fiedler, J. Kurths, & E. Schöll (Eds.), Analysis and control of complex nonlinear processes in physics, chemistry and biology (293-324). World Scientific. https://doi.org/10.1142/9789812706911_0011

We analyze the elemental time scale of intracellular calcium dynamics. It is determined by the time course of Ca2+ puffs, which represent the fundamental quantum of Ca2+ release from intracellular storage compartments. Since Ca2+ puffs are truly rand... Read More about Building oscillations bottom up: Elemental time scales of intracellular calcium dynamics.

Frequency of elemental events of intracellular Ca²⁺ dynamics (2006)
Journal Article
Thul, R., & Falcke, M. (2006). Frequency of elemental events of intracellular Ca²⁺ dynamics. Physical Review E, 73, Article 061923. https://doi.org/10.1103/PhysRevE.73.061923

The dynamics of intracellular Ca²⁺ is driven by random events called Ca²⁺ puffs, in which Ca²⁺ is liberated from intracellular stores. We show that the emergence of Ca²⁺ puffs can be mapped to an escape process. The mean first passage times that corresp... Read More about Frequency of elemental events of intracellular Ca²⁺ dynamics.

The multimedia challenges raised by pervasive games (2005)
Presentation / Conference Contribution
Capra, M., Radenkovic, M., Benford, S., Oppermann, L., Drozd, A., & Flintham, M. The multimedia challenges raised by pervasive games. Presented at 13th Annual ACM International Conference on Multimedia (MULTIMEDIA '05)

Pervasive gaming is a new form of multimedia entertainment that extends the traditional computer gaming experience out into the real world. Through a combination of personal devices, positioning systems and other multimedia sensors, combined with wir... Read More about The multimedia challenges raised by pervasive games.

Release currents of IP₃ receptor channel clusters and concentration profiles (2004)
Journal Article
Thul, R., & Falcke, M. (2004). Release currents of IP₃ receptor channel clusters and concentration profiles. Biophysical Journal, 86(5),

We simulate currents and concentration profiles generated by Ca2+ release from the endoplasmic reticulum (ER)
to the cytosol through IP3 receptor channel clusters. Clusters are described as conducting pores in the lumenal membrane with a diameter f... Read More about Release currents of IP₃ receptor channel clusters and concentration profiles.

Stability of membrane bound reactions (2004)
Journal Article
Thul, R., & Falcke, M. (2004). Stability of membrane bound reactions. Physical Review Letters, 93(18), https://doi.org/10.1103/+PhysRevLet+t.93.188103

We present a novel approach to the dynamics of reactions of diffusing chemical species with species fixed in space e.g. by binding to a membrane. The non-diffusing reaction partners are clustered in areas with a diameter smaller than the diffusion length... Read More about Stability of membrane bound reactions.