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Frequency of elemental events of intracellular Ca²⁺ dynamics

Thul, Ruediger; Falcke, Martin

Authors

Ruediger Thul ruediger.thul@nottingham.ac.uk

Martin Falcke

Abstract

The dynamics of intracellular Ca²⁺ is driven by random events called Ca²⁺ puffs, in which Ca²⁺ is liberated from intracellular stores. We show that the emergence of Ca²⁺ puffs can be mapped to an escape process. The mean first passage times that correspond to the stochastic fraction of puff periods are computed from a novel master equation and two Fokker-Planck equations. Our results demonstrate that the mathematical modeling of Ca²⁺ puffs has to account for the discrete character of the Ca²⁺ release sites and does not permit a continuous description of the number of
open channels.

Journal Article Type Article
Publication Date Jun 29, 2006
Journal Physical Review E
Print ISSN 2470-0045
Electronic ISSN 1539-3755
Publisher American Physical Society
Peer Reviewed Peer Reviewed
Volume 73
Article Number 061923
Institution Citation Thul, R., & Falcke, M. (2006). Frequency of elemental events of intracellular Ca²⁺ dynamics. Physical Review E, 73, doi:10.1103/PhysRevE.73.061923
DOI https://doi.org/10.1103/PhysRevE.73.061923
Publisher URL http://journals.aps.org/pre/abstract/10.1103/PhysRevE.73.061923
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf




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