Frequency of elemental events of intracellular Ca²⁺ dynamics

Thul, Ruediger; Falcke, Martin

Abstract

The dynamics of intracellular Ca²⁺ is driven by random events called Ca²⁺ puffs, in which Ca²⁺ is liberated from intracellular stores. We show that the emergence of Ca²⁺ puffs can be mapped to an escape process. The mean first passage times that correspond to the stochastic fraction of puff periods are computed from a novel master equation and two Fokker-Planck equations. Our results demonstrate that the mathematical modeling of Ca²⁺ puffs has to account for the discrete character of the Ca²⁺ release sites and does not permit a continuous description of the number of
open channels.

Citation

Thul, R., & Falcke, M. (2006). Frequency of elemental events of intracellular Ca²⁺ dynamics. Physical Review E, 73, Article 061923. https://doi.org/10.1103/PhysRevE.73.061923

• Journal Article Type: Article
• Publication Date: Jun 29, 2006
• Deposit Date: Nov 19, 2008
• Publicly Available Date: Nov 19, 2008
• Journal: Physical Review E
• Print ISSN: 2470-0045
• Electronic ISSN: 2470-0053
• Publisher: American Physical Society
• Peer Reviewed: Peer Reviewed
• Volume: 73
• Article Number: 061923
• DOI: https://doi.org/10.1103/PhysRevE.73.061923
• Public URL: https://nottingham-repository.worktribe.com/output/703699
• Publisher URL: http://journals.aps.org/pre/abstract/10.1103/PhysRevE.73.061923
• Contract Date: Nov 19, 2008