All Outputs (182)

Misappropriation of the 1986 WHO analgesic ladder: the pitfalls of labelling opioids as weak or strong (2022)
Journal Article
Crush, J., Levy, N., Knaggs, R. D., & Lobo, D. N. (2022). Misappropriation of the 1986 WHO analgesic ladder: the pitfalls of labelling opioids as weak or strong. British Journal of Anaesthesia, 129(2), 137-142. https://doi.org/10.1016/j.bja.2022.03.004

Opioids have a vital role in alleviating pain from cancer and surgery. Despite good intentions, it is now recognised that the original WHO Cancer Pain Relief guidance from 1986, in which opioids were classified as either weak or strong, has been both... Read More about Misappropriation of the 1986 WHO analgesic ladder: the pitfalls of labelling opioids as weak or strong.

Early Postoperative Supplementary Parenteral Nutrition (2022)
Journal Article
Ljungqvist, O., Gustafsson, U. O., & Lobo, D. N. (2022). Early Postoperative Supplementary Parenteral Nutrition. JAMA Surgery, 209, Article 118333. https://doi.org/10.1001/jamasurg.2022.0266

Molten salts have been used in solar thermal energy storage due to their high energy storage density, low cost and excellent chemical stability. However, their application is limited by “bad days” such as cloudy days and winter because the weak conce... Read More about Early Postoperative Supplementary Parenteral Nutrition.

System-level policies on appropriate opioid use, a multi-stakeholder consensus (2022)
Journal Article
Forget, P., Patullo, C., Hill, D., Ambekar, A., Baldacchino, A., Cata, J., Chetty, S., Cox, F. J., de Boer, H. D., Dinwoodie, K., Dom, G., Eccleston, C., Fullen, B., Jutila, L., Knaggs, R. D., Lavand’homme, P., Levy, N., Lobo, D. N., Pogatzki-Zahn, E., Scherbaum, N., …Gilbert, S. (2022). System-level policies on appropriate opioid use, a multi-stakeholder consensus. BMC Health Services Research, 22(1), Article 329. https://doi.org/10.1186/s12913-022-07696-x

Background: This consensus statement was developed because there are concerns about the appropriate use of opioids for acute pain management, with opposing views in the literature. Consensus statement on policies for system-level interventions may he... Read More about System-level policies on appropriate opioid use, a multi-stakeholder consensus.

Mapping brain activity of gut-brain signaling to appetite and satiety in healthy adults: A systematic review and functional neuroimaging meta-analysis (2022)
Journal Article
Althubeati, S., Avery, A., Tench, C., Lobo, D. N., Salter, A., & Eldeghaidy, S. (2022). Mapping brain activity of gut-brain signaling to appetite and satiety in healthy adults: A systematic review and functional neuroimaging meta-analysis. Neuroscience and Biobehavioral Reviews, 136, Article 104603. https://doi.org/10.1016/j.neubiorev.2022.104603

Understanding how neurohormonal gut-brain signaling regulates appetite and satiety is vital for the development of therapies for obesity and altered eating behavior. However, reported brain areas associated with appetite or satiety regulators show in... Read More about Mapping brain activity of gut-brain signaling to appetite and satiety in healthy adults: A systematic review and functional neuroimaging meta-analysis.

Validation of modified GLIM criteria to predict adverse clinical outcome and response to nutritional treatment: A secondary analysis of a randomized clinical trial (2022)
Journal Article
Kaegi-Braun, N., Boesiger, F., Tribolet, P., Gomes, F., Kutz, A., Hoess, C., Pavlicek, V., Bilz, S., Sigrist, S., Brändle, M., Henzen, C., Thomann, R., Rutishauser, J., Aujesky, D., Rodondi, N., Donzé, J., Stanga, Z., Lobo, D. N., Cederholm, T., Mueller, B., & Schuetz, P. (2022). Validation of modified GLIM criteria to predict adverse clinical outcome and response to nutritional treatment: A secondary analysis of a randomized clinical trial. Clinical Nutrition, 41(4), 795-804. https://doi.org/10.1016/j.clnu.2022.02.009

Background & aims: The Global Leadership Initiative on Malnutrition (GLIM) recently suggested specific criteria to standardize the diagnosis of malnutrition. There is need for validation of these criteria regarding response to nutrition treatment. Ou... Read More about Validation of modified GLIM criteria to predict adverse clinical outcome and response to nutritional treatment: A secondary analysis of a randomized clinical trial.

Admission serum albumin concentrations and response to nutritional therapy in hospitalised patients at malnutrition risk: Secondary analysis of a randomised clinical trial (2022)
Journal Article
Bretschera, C., Boesiger, F., Kaegi-Braun, N., Hersberger, L., Lobo, D. N., Evans, D. C., Tribolet, P., Gomes, F., Hoess, C., Pavlicek, V., Bilz, S., Sigrist, S., Brändle, M., Henzen, C., Thomann, R., Rutishauser, J., Aujesky, D., Rodondi, N., Donzé, J., Stanga, Z., …Schuetz, P. (2022). Admission serum albumin concentrations and response to nutritional therapy in hospitalised patients at malnutrition risk: Secondary analysis of a randomised clinical trial. eClinicalMedicine, 45, Article 101301. https://doi.org/10.1016/j.eclinm.2022.101301

Background
Historically, admission serum albumin concentrations have been considered useful biochemical markers for nutrition assessment. However, there is a lack of randomised trial data investigating whether low albumin concentrations are helpful... Read More about Admission serum albumin concentrations and response to nutritional therapy in hospitalised patients at malnutrition risk: Secondary analysis of a randomised clinical trial.

The effects of elective abdominal surgery on protein turnover: A meta-analysis of stable isotope techniques to investigate postoperative catabolism (2022)
Journal Article
Jaconelli, M., Greenhaff, P. L., Atherton, P. J., Lobo, D. N., & Brook, M. S. (2022). The effects of elective abdominal surgery on protein turnover: A meta-analysis of stable isotope techniques to investigate postoperative catabolism. Clinical Nutrition, 41(3), 709-722. https://doi.org/10.1016/j.clnu.2022.01.023

Background & aims

Elective surgery induces skeletal muscle wasting driven by an imbalance between muscle protein synthesis and breakdown. From examination of diverse stable isotope tracer techniques, the dynamic processes driving this imbalance ar... Read More about The effects of elective abdominal surgery on protein turnover: A meta-analysis of stable isotope techniques to investigate postoperative catabolism.

Anti-miR-135/SPOCK1 axis antagonizes the influence of metabolism on drug response in intestinal/colon tumour organoids (2022)
Journal Article
Babaei-Jadidi, R., Kashfi, H., Alelwani, W., Bakhtiari, A., Kattan, S. W., Mansouri, O. A., Mukherjee, A., Lobo, D. N., & Nateri, A. S. (2022). Anti-miR-135/SPOCK1 axis antagonizes the influence of metabolism on drug response in intestinal/colon tumour organoids. Oncogenesis, 11, Article 4. https://doi.org/10.1038/s41389-021-00376-1

Little is known about the role of microRNAs (miRNAs) in rewiring the metabolism within tumours and adjacent non-tumour bearing normal tissue and their potential in cancer therapy. This study aimed to investigate the relationship between deregulated m... Read More about Anti-miR-135/SPOCK1 axis antagonizes the influence of metabolism on drug response in intestinal/colon tumour organoids.

Utility of unidimensional and functional pain assessment tools in adult postoperative patients: a systematic review (2022)
Journal Article
Baamer, R. M., Iqbal, A., Lobo, D. N., Knaggs, R. D., Levy, N. A., & Toh, L. S. (2022). Utility of unidimensional and functional pain assessment tools in adult postoperative patients: a systematic review. British Journal of Anaesthesia, 128(5), 874-888. https://doi.org/10.1016/j.bja.2021.11.032

Background: We aimed to appraise the evidence relating to the measurement properties of unidimensional tools to quantify pain after surgery. Furthermore, we wished to identify the tools used to assess interference of pain with functional recovery. Me... Read More about Utility of unidimensional and functional pain assessment tools in adult postoperative patients: a systematic review.

Current Issues in the Use of Opioids for the Management of Postoperative Pain: A Review (2021)
Journal Article
Macintyre, P. E., Quinlan, J., Levy, N., & Lobo, D. N. (2022). Current Issues in the Use of Opioids for the Management of Postoperative Pain: A Review. JAMA Surgery, 157(2), 158-166. https://doi.org/10.1001/jamasurg.2021.6210

Importance: Uncontrolled and indiscriminate prescribing of opioids has led to an opioid crisis that started in North America and spread throughout high-income countries. The aim of this narrative review was to explore some of the current issues surro... Read More about Current Issues in the Use of Opioids for the Management of Postoperative Pain: A Review.

The importance of protein sources to support muscle anabolism in cancer: An expert group opinion (2021)
Journal Article
Ford, K. L., Arends, J., Atherton, P. J., Engelen, M. P., Gonçalves, T. J., Laviano, A., Lobo, D. N., Phillips, S. M., Ravasco, P., Deutz, N. E., & Prado, C. M. (2022). The importance of protein sources to support muscle anabolism in cancer: An expert group opinion. Clinical Nutrition, 41(1), 192-201. https://doi.org/10.1016/j.clnu.2021.11.032

This opinion paper presents a short review of the potential impact of protein on muscle anabolism in cancer, which is associated with better patient outcomes. Protein source is a topic of interest for patients and clinicians, partly due to recent emp... Read More about The importance of protein sources to support muscle anabolism in cancer: An expert group opinion.

Response to Igor Eckert: Sometimes, the absence of evidence is evidence of its absence (2021)
Journal Article
Adiamah, A., Allison, S. P., & Lobo, D. N. (2022). Response to Igor Eckert: Sometimes, the absence of evidence is evidence of its absence. Clinical Nutrition, 41(1), 261-262. https://doi.org/10.1016/j.clnu.2021.11.022

Burnout Among Surgeons in the UK During the COVID-19 Pandemic: A Cohort Study (2021)
Journal Article
Houdmont, J., Daliya, P., Theophilidou, E., Adiamah, A., Hassard, J., Lobo, D. N., & East Midlands Surgical Academic Network (EMSAN) Burnout Study Group. (2022). Burnout Among Surgeons in the UK During the COVID-19 Pandemic: A Cohort Study. World Journal of Surgery, 46(1), 1-9. https://doi.org/10.1007/s00268-021-06351-6

Background: Surgeon burnout has implications for patient safety and workforce sustainability. The aim of this study was to establish the prevalence of burnout among surgeons in the UK during the COVID-19 pandemic.

Methods: This cross-sectional on... Read More about Burnout Among Surgeons in the UK During the COVID-19 Pandemic: A Cohort Study.

Bowel Preparation for Colorectal Surgery: Have All Questions Been Answered? (2021)
Journal Article
Ljungqvist, O., & Lobo, D. N. (2021). Bowel Preparation for Colorectal Surgery: Have All Questions Been Answered?. JAMA Surgery, 157(1), 41-42. https://doi.org/10.1001/jamasurg.2021.5273

Rosenberg and colleagues1 first proposed the use of nonabsorbable oral antibiotic preparation (OAB) for colorectal surgery in 1971. In a randomized clinical trial, they demonstrated a reduction in surgical site infection and anastomotic leak rates af... Read More about Bowel Preparation for Colorectal Surgery: Have All Questions Been Answered?.

Incidence and treatment of splanchnic vein thrombosis in patients with acute pancreatitis: A systematic review and meta-analysis (2021)
Journal Article
Anis, F. S., Adiamah, A., Lobo, D. N., & Sanyal, S. (2022). Incidence and treatment of splanchnic vein thrombosis in patients with acute pancreatitis: A systematic review and meta-analysis. Journal of Gastroenterology and Hepatology, 37(3), 446-454. https://doi.org/10.1111/jgh.15711

Background and Aim: This meta-analysis aimed to estimate the incidence of splanchnic vein thrombosis (SVT) in patients with acute pancreatitis and assess the effects of therapeutic anticoagulation. Methods: Systematic searches of the Medline, Embase,... Read More about Incidence and treatment of splanchnic vein thrombosis in patients with acute pancreatitis: A systematic review and meta-analysis.

Management of disease-related malnutrition for patients being treated in hospital (2021)
Journal Article
Schuetz, P., Seres, D., Lobo, D. N., Gomes, F., Kaegi-Braun, N., & Stanga, Z. (2021). Management of disease-related malnutrition for patients being treated in hospital. Lancet, 398(10314), 1927-1938. https://doi.org/10.1016/S0140-6736%2821%2901451-3

Disease-related malnutrition in adult patients who have been admitted to hospital is a syndrome associated with substantially increased morbidity, disability, short-term and long-term mortality, impaired recovery from illness, and cost of care. There... Read More about Management of disease-related malnutrition for patients being treated in hospital.

Postoperative arginine-enriched immune modulating nutrition: Long-term survival results from a randomised clinical trial in patients with oesophagogastric and pancreaticobiliary cancer (2021)
Journal Article
Adiamah, A., Rollins, K. E., Kapeleris, A., Welch, N. T., Iftikhar, S. Y., Allison, S. P., & Lobo, D. N. (2021). Postoperative arginine-enriched immune modulating nutrition: Long-term survival results from a randomised clinical trial in patients with oesophagogastric and pancreaticobiliary cancer. Clinical Nutrition, 40(11), 5482-5485. https://doi.org/10.1016/j.clnu.2021.09.040

Background & aims: Immune modulating nutrition (IMN) has been shown to reduce postoperative infectious complications and length of stay in patients with gastrointestinal cancer. Two studies of IMN in patients undergoing surgery for head and neck canc... Read More about Postoperative arginine-enriched immune modulating nutrition: Long-term survival results from a randomised clinical trial in patients with oesophagogastric and pancreaticobiliary cancer.

Immunohistochemical inflammation in histologically normal appendices in patients with right iliac fossa pain (2021)
Journal Article
Psaltis, E., Zaitoun, A. M., Neal, K. R., & Lobo, D. N. (2021). Immunohistochemical inflammation in histologically normal appendices in patients with right iliac fossa pain. World Journal of Surgery, 45(12), 3592-3602. https://doi.org/10.1007/s00268-021-06288-w

Background
Histologically normal appendices resected for right iliac fossa pain in children demonstrate immunohistochemical markers of inflammation. We aimed to establish if subclinical inflammation was present in histologically normal appendices re... Read More about Immunohistochemical inflammation in histologically normal appendices in patients with right iliac fossa pain.

Publication Rates, Ethnic and Sex Disparities in UK and Ireland Surgical Research Prize Presentations: An Analysis of Data From the Moynihan and Patey Prizes From 2000 to 2020 (2021)
Journal Article
Seehra, J. K., Lewis-Lloyd, C., Koh, A., Theophilidou, E., Daliya, P., Adiamah, A., & Lobo, D. N. (2021). Publication Rates, Ethnic and Sex Disparities in UK and Ireland Surgical Research Prize Presentations: An Analysis of Data From the Moynihan and Patey Prizes From 2000 to 2020. World Journal of Surgery, 45(11), 3266-3277. https://doi.org/10.1007/s00268-021-06268-0

Background: Presentation at academic conferences is an important marker of research productivity. However, not all accepted abstracts progress to full publication, and there is anecdotal evidence suggesting an imbalance in sex and ethnicity amongst p... Read More about Publication Rates, Ethnic and Sex Disparities in UK and Ireland Surgical Research Prize Presentations: An Analysis of Data From the Moynihan and Patey Prizes From 2000 to 2020.

Perioperative Opioids - Reclaiming Lost Ground (2021)
Journal Article
Fawcett, W. J., Ljungqvist, O., & Lobo, D. N. (2021). Perioperative Opioids - Reclaiming Lost Ground. JAMA Surgery, 156(11), 997-998. https://doi.org/10.1001/jamasurg.2021.2858

Opium (poppy tears) has been in use since 3400 BCE, with historical writings recording its sedative, euphoric, and analgesic properties, but it was not until the 19th century that morphine was isolated, paving the way for its therapeutic use. The 20t... Read More about Perioperative Opioids - Reclaiming Lost Ground.