All Outputs (98)

Bidirectional association between disturbed sleep and neuropathic pain symptoms: a prospective cohort study in post-total joint replacement participants (2018)
Journal Article

Disturbed sleep is strongly correlated with chronic pain. The aim of this study was to examine the association between sleep disturbance and incident joint pain focusing on neuropathic pain-like symptoms. 423 individuals who had undergone total joint... Read More about Bidirectional association between disturbed sleep and neuropathic pain symptoms: a prospective cohort study in post-total joint replacement participants.

A clinical assessment tool to improve the use of pain relieving treatments in knee osteoarthritis (2018)
Journal Article

Purpose: Approximately 1 in 4 individuals in the UK over the age of 55 experience knee pain (KP), predominantly due to osteoarthritis (OA). Following treatment targeted at the affected knee, pain relief is reported in only 60%–80% of individuals with... Read More about A clinical assessment tool to improve the use of pain relieving treatments in knee osteoarthritis.

General and disease-specific pain trajectories as predictors of social and political outcomes in arthritis and cancer (2018)
Journal Article

Background: While the heterogeniety of pain progression has been studied in chronic diseases, it is unclear the extent to which patterns of pain progression among people in general as well as across different diseases impacts on social, civic and po... Read More about General and disease-specific pain trajectories as predictors of social and political outcomes in arthritis and cancer.

Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis (2018)
Journal Article

Background: DAS28 is interpreted as the inflammatory disease activity of RA. Non-inflammatory pain mechanisms can confound assessment. We aimed to examine the use of DAS28 components or DAS28-derived measures that have been published as indices of no... Read More about Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis.

Traits associated with central pain augmentation in the Knee Pain in the Community (KPIC) cohort (2018)
Journal Article

This study aimed to identify self-report correlates of central pain augmentation in individuals with knee pain. A subset of participants (n=420) in the Knee Pain and related health In the Community (KPIC) baseline survey undertook pressure pain thres... Read More about Traits associated with central pain augmentation in the Knee Pain in the Community (KPIC) cohort.

Home-based pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): a feasibility randomised controlled trial (2018)
Journal Article

Objective: To determine the feasibility of conducting a trial of a pre-surgical psychological intervention on pain, function, and mood in people with knee osteoarthritis listed for total knee arthroplasty. Design: Multi-centre, mixed-methods feasibi... Read More about Home-based pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): a feasibility randomised controlled trial.

Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data (2017)
Journal Article

Background: Recently an important role for synovial pathology in the initiation and progression of knee osteoarthritis (OA) has been emphasised. This study aimed to examine whether ultrasonographydetected synovial changes (USSCs) associate with knee... Read More about Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data.

Pain mechanisms in rheumatoid arthritis (2017)
Journal Article

Understanding of the causes and underlying mechanisms of pain in people with RA is rapidly changing. With the advent of more effective disease modifying drugs, joint inflammation is becoming a more treatable cause of pain, and joint damage can often... Read More about Pain mechanisms in rheumatoid arthritis.

Knee pain and related health in the community study (KPIC): a cohort study protocol (2017)
Journal Article

Background: The incidence, progression and related risk factors for recent-onset knee pain (KP) remain uncertain. This study aims to examine the natural history of KP including incidence and progression and to identify possible phenotypes and their a... Read More about Knee pain and related health in the community study (KPIC): a cohort study protocol.

Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome (2017)
Journal Article

Introduction: Osteoarthritis (OA) pain is a major cause of long-term disability and chronic pain in the adult population. One in five patients does not receive satisfactory pain relief, which reflects the complexity of chronic pain and the current la... Read More about Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome.

New therapeutic targets for osteoarthritis pain (2017)
Journal Article

Osteoarthritis (OA), the most common form of arthritis, causes pain and disability, as well as emotional distress. While total joint replacement is one of the most effective treatments available for improving the quality of life in people with severe... Read More about New therapeutic targets for osteoarthritis pain.

Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR 1) gene (2017)
Journal Article

Background: Substance P (SP) is a pain- and inflammation-related neuropeptide which preferentially binds to the neurokinin receptor 1 (NK1). SP and NK1 receptors have been implicated in joint pain, inflammation and damage in animal models and human s... Read More about Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR 1) gene.

Arthritis pain: moving between early- and late- stage disease (2017)
Journal Article

Reductions in radiographic progression in early RA over 25-years: changing contribution from RF in 2 multi-centre UK inception cohorts (2017)
Journal Article

Objectives: To assess 5-year progression of erosions and Joint Space Narrowing (JSN), and their associations with RF status in two large, multi-centre early-RA cohorts spanning 25-years. Methods: Radiographic joint damage was recorded using the Sh... Read More about Reductions in radiographic progression in early RA over 25-years: changing contribution from RF in 2 multi-centre UK inception cohorts.

Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA (2017)
Journal Article

Objectives: To investigate serum biomarkers, tartrate resistant acid phosphatase 5b (TRAcP5b) and cathepsin K, indicative of osteoclastic bone resorption, and their relationship to pain and pain change in knee osteoarthritis (OA). Methods: Sera and... Read More about Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA.

Discordant inflammation and pain in early and established rheumatoid arthritis: Latent Class Analysis of Early Rheumatoid Arthritis Network and British Society for Rheumatology Biologics Register data (2016)
Journal Article

Background Rheumatoid arthritis (RA) disease activity is often measured using the 28 joint Disease Activity Score (DAS28). We aimed to identify and independently verify subgroups of people with RA that may be discordant with respect to self-reported... Read More about Discordant inflammation and pain in early and established rheumatoid arthritis: Latent Class Analysis of Early Rheumatoid Arthritis Network and British Society for Rheumatology Biologics Register data.

Identifying placebo responders and predictors of response in osteoarthritis: a protocol for individual patient data meta-analysis (2016)
Journal Article

Background: The management of osteoarthritis (OA) is unsatisfactory, as most treatments are not clinically effective over placebo and most drugs have considerable side effects. On average, 75 % of the analgesic effect from OA treatments in clinical t... Read More about Identifying placebo responders and predictors of response in osteoarthritis: a protocol for individual patient data meta-analysis.

Histopathological subgroups in knee osteoarthritis (2016)
Journal Article

Objective: Osteoarthritis (OA) is a heterogeneous, multi-tissue disease. We hypothesised that different histopathological features characterise different stages during knee OA progression, and that discrete subgroups can be defined based on validated... Read More about Histopathological subgroups in knee osteoarthritis.

Relative efficacy of topical non-steroidal anti-inflammatory drugs and topical capsaicin in osteoarthritis: protocol for an individual patient data meta-analysis (2016)
Journal Article

Background Pain is the most troubling issue to patients with osteoarthritis (OA), yet current pharmacological treatments offer only small-to-moderate pain reduction. Current guidelines therefore emphasise the need to identify predictors of treatme... Read More about Relative efficacy of topical non-steroidal anti-inflammatory drugs and topical capsaicin in osteoarthritis: protocol for an individual patient data meta-analysis.

Factors predicting pain and early discontinuation of tumour necrosis factor-?-inhibitors in people with rheumatoid arthritis: results from the British society for rheumatology biologics register (2016)
Journal Article

Background: We examined pain levels in 2 cohorts assembled from the British Society for Rheumatology Biologics Register (BSRBR), and investigated which factors predicted Bodily Pain scores and discontinuation of TNF?-inhibitors. Method: Data were re... Read More about Factors predicting pain and early discontinuation of tumour necrosis factor-?-inhibitors in people with rheumatoid arthritis: results from the British society for rheumatology biologics register.