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Bidirectional association between disturbed sleep and neuropathic pain symptoms: a prospective cohort study in post-total joint replacement participants

Stocks, Joanne; Tang, Nicole K.Y.; Walsh, David A.; Warner, Sophie C.; Harvey, Hollie; Jenkins, Wendy; Abhishek, Abhishek; Doherty, Michael; Valdes, Ana M.

Bidirectional association between disturbed sleep and neuropathic pain symptoms: a prospective cohort study in post-total joint replacement participants Thumbnail


Authors

Nicole K.Y. Tang

DAVID WALSH david.walsh@nottingham.ac.uk
Professor of Rheumatology

Sophie C. Warner

Hollie Harvey

Wendy Jenkins

Michael Doherty



Abstract

Disturbed sleep is strongly correlated with chronic pain. The aim of this study was to examine the association between sleep disturbance and incident joint pain focusing on neuropathic pain-like symptoms. 423 individuals who had undergone total joint replacement (TJR) for osteoarthritis (OA) were assessed 3.6 years post-surgery, using the Medical Outcomes Survey sleep subscale, the WOMAC and PainDETECT instruments, and again 5.9 years post-TJR. Cox hazards ratios (HR) and 95% confidence intervals (CIs) were computed adjusting for age, BMI, sex, use of hypnotic and analgesic medication. The presence of neuropathic pain symptoms predicted incidence of disturbed sleep after adjustment for covariates and pain severity (aHR 2.01, 95% CI: 1.00-4.10 p

Citation

Stocks, J., Tang, N. K., Walsh, D. A., Warner, S. C., Harvey, H., Jenkins, W., …Valdes, A. M. (2018). Bidirectional association between disturbed sleep and neuropathic pain symptoms: a prospective cohort study in post-total joint replacement participants. Journal of Pain Research, 2018(11), 1087—1093. https://doi.org/10.2147/JPR.S149830

Journal Article Type Article
Acceptance Date Nov 29, 2017
Publication Date Jun 6, 2018
Deposit Date Dec 5, 2017
Publicly Available Date Aug 16, 2018
Journal Journal of Pain Research
Electronic ISSN 1178-7090
Publisher Dove Medical Press
Peer Reviewed Peer Reviewed
Volume 2018
Issue 11
Pages 1087—1093
DOI https://doi.org/10.2147/JPR.S149830
Keywords total joint replacement; opioids; osteoarthritis;
Public URL https://nottingham-repository.worktribe.com/output/896896
Publisher URL https://www.dovepress.com/bidirectional-association-between-disturbed-sleep-and-neuropathic-pain-peer-reviewed-article-JPR

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