Resolution of the three dimensional structure of components of the glomerular filtration barrier

Qvortrup, Klaus; ARKILL, KENTON; Starborg, Tobias; Mantell, Judith; Knupp, Carlo; Michel, Charles; Harper, Steve; Salmon, Andy; Squire, John; Bates, Dave; Neal, Chris

doi:10.1186/1471-2369-15-24

All Outputs (7)

Serine-arginine protein kinase 1 (SRPK1) inhibition as a potential novel targeted therapeutic strategy in prostate cancer (2014)
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Angiogenesis is required for tumour growth and is induced principally by vascular endothelial growth factor A (VEGF-A). VEGF-A pre-mRNA is alternatively spliced at the terminal exon to produce two families of isoforms, pro- and anti-angiogenic, only... Read More about Serine-arginine protein kinase 1 (SRPK1) inhibition as a potential novel targeted therapeutic strategy in prostate cancer.

An antiangiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease (2014)
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Regulation of alternative VEGF-A mRNA splicing is a therapeutic target for analgesia (2014)
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Vascular endothelial growth factor-A (VEGF-A) is best known as a key regulator of the formation of new blood vessels. Neutralization of VEGF-A with anti-VEGF therapy e.g. bevacizumab, can be painful, and this is hypothesized to result from a loss of... Read More about Regulation of alternative VEGF-A mRNA splicing is a therapeutic target for analgesia.

Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, angiogenesis, tumour growth and bevacizumab resistance (2014)
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Antiangiogenic actions of vascular endothelial growth factor-A165b, an inhibitory isoform of vascular endothelial growth factor-A, in human obesity (2014)
Journal Article

Background—Experimental studies suggest that visceral adiposity and adipose tissue dysfunction play a central role in obesity-related cardiometabolic complications. Impaired angiogenesis in fat has been implicated in the development of adipose tissue... Read More about Antiangiogenic actions of vascular endothelial growth factor-A165b, an inhibitory isoform of vascular endothelial growth factor-A, in human obesity.

Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma (2014)
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Resolution of the three dimensional structure of components of the glomerular filtration barrier (2014)
Journal Article

Background: The human glomerulus is the primary filtration unit of the kidney, and contains the Glomerular Filtration Barrier (GFB). The GFB had been thought to comprise 3 layers - the endothelium, the basement membrane and the podocyte foot processe... Read More about Resolution of the three dimensional structure of components of the glomerular filtration barrier.