Klaus Qvortrup
Resolution of the three dimensional structure of components of the glomerular filtration barrier
Qvortrup, Klaus; ARKILL, KENTON; Starborg, Tobias; Mantell, Judith; Knupp, Carlo; Michel, Charles; Harper, Steve; Salmon, Andy; Squire, John; Bates, Dave; Neal, Chris
Authors
KENTON ARKILL Kenton.Arkill@nottingham.ac.uk
Associate Professor
Tobias Starborg
Judith Mantell
Carlo Knupp
Charles Michel
Steve Harper
Andy Salmon
John Squire
DAVID BATES David.Bates@nottingham.ac.uk
Professor of Oncology
Chris Neal
Abstract
Background: The human glomerulus is the primary filtration unit of the kidney, and contains the Glomerular Filtration Barrier (GFB). The GFB had been thought to comprise 3 layers - the endothelium, the basement membrane and the podocyte foot processes. However, recent studies have suggested that at least two additional layers contribute to the function of the GFB, the endothelial glycocalyx on the vascular side, and the sub-podocyte space on the urinary side. To investigate the structure of these additional layers is difficult as it requires three-dimensional reconstruction of delicate sub-microscopic (
Citation
Qvortrup, K., ARKILL, K., Starborg, T., Mantell, J., Knupp, C., Michel, C., …Neal, C. (2014). Resolution of the three dimensional structure of components of the glomerular filtration barrier. BMC Nephrology, 15(1), Article 24. https://doi.org/10.1186/1471-2369-15-24
Journal Article Type | Article |
---|---|
Acceptance Date | Jan 21, 2014 |
Online Publication Date | Feb 1, 2014 |
Publication Date | Feb 1, 2014 |
Deposit Date | Aug 28, 2018 |
Journal | BMC Nephrology |
Electronic ISSN | 1471-2369 |
Publisher | Springer Verlag |
Peer Reviewed | Peer Reviewed |
Volume | 15 |
Issue | 1 |
Article Number | 24 |
DOI | https://doi.org/10.1186/1471-2369-15-24 |
Public URL | https://nottingham-repository.worktribe.com/output/1104954 |
Publisher URL | https://bmcnephrol.biomedcentral.com/articles/10.1186/1471-2369-15-24 |
PMID | 00033212 |
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