All Outputs (68)

Inflammation and angiogenesis in osteoarthritis (2003)
Journal Article
Haywood, L., McWilliams, D. F., Pearson, C. I., Gill, S. E., Ganesan, A., Wilson, D., & Walsh, D. A. (2003). Inflammation and angiogenesis in osteoarthritis. Arthritis and Rheumatism, 48(8), 2173-2177. https://doi.org/10.1002/art.11094

Objective. To quantify the relationship between inflammation and angiogenesis in synovial tissue from patients with osteoarthritis (OA). Methods. Hematoxylin and eosin staining and histologic grading for inflammation were performed for 104 patients w... Read More about Inflammation and angiogenesis in osteoarthritis.

Genetic modification of cell lines to enhance their metastatic capability (2001)
Book Chapter
D, M., & H, C. (2001). Genetic modification of cell lines to enhance their metastatic capability. In S. A. Brooks, & U. Schumacher (Eds.), Metastasis Research Protocols (25-30). Springer. https://doi.org/10.1385/1-59259-137-X%3A025

Antibodies raised against the extracellular tail of the CCKB/gastrin receptor inhibit gastrin-stimulated signalling (2001)
Journal Article
McWilliams, D. F., Grimes, S., & Watson, S. A. (2001). Antibodies raised against the extracellular tail of the CCKB/gastrin receptor inhibit gastrin-stimulated signalling. Regulatory Peptides, 99(2-3), 157-161. https://doi.org/10.1016/S0167-0115%2801%2900245-2

Introduction: Gastrin acts to stimulate gastric acid secretion and is an acknowledged growth factor for human gastrointestinal (GI) cancer. The identity of the exact receptor type mediating the growth promoting effects of gastrin in tumours is uncert... Read More about Antibodies raised against the extracellular tail of the CCKB/gastrin receptor inhibit gastrin-stimulated signalling.

Coexpression of gastrin and gastrin receptors (CCK-B and ΔCCK-B) in gastrointestinal tumour cell lines (1998)
Journal Article
McWilliams, D. F., Watson, S. A., Crosbee, D. M., Michaeli, D., & Seth, R. (1998). Coexpression of gastrin and gastrin receptors (CCK-B and ΔCCK-B) in gastrointestinal tumour cell lines. Gut, 42(6), 795-798. https://doi.org/10.1136/gut.42.6.795

Background - The peptide hormone gastrin is a recognised growth factor for gastrointestinal (GI) tumour cells. Carboxyamidated gastrins bind to the cell surface gastrin/cholecystokinin B (CCK-B) receptor which can be expressed as either a normal or a... Read More about Coexpression of gastrin and gastrin receptors (CCK-B and ΔCCK-B) in gastrointestinal tumour cell lines.

A clinical assessment tool to improve the use of pain relieving treatments in knee osteoarthritis
Presentation / Conference Contribution
Akin-Akinyosoye, K., Frowd, N., Marshall, L., Stocks, J., Fernandes, G., Valdes, A., McWilliams, D., Zhang, W., Doherty, M., Ferguson, E., & Walsh, D. (2018, April). A clinical assessment tool to improve the use of pain relieving treatments in knee osteoarthritis. Presented at 2018 OARSI World Congress on Osteoarthritis : Promoting Clinical and Basic Research in Osteoarthritis, Liverpool, United Kingdom

Purpose: Approximately 1 in 4 individuals in the UK over the age of 55 experience knee pain (KP), predominantly due to osteoarthritis (OA). Following treatment targeted at the affected knee, pain relief is reported in only 60%–80% of individuals with... Read More about A clinical assessment tool to improve the use of pain relieving treatments in knee osteoarthritis.

Mediators of the predictive relationship between a self-report measure of central mechanisms and future knee pain outcomes in the knee pain in the community (KPIC) cohort
Presentation / Conference Contribution
Matthews, R., Akin-Akinyosoye, K., Frowd, N., Swaithes, L., Stocks, J., Sarmanova, A., Fernandes, G. S., Valdes, A., McWilliams, D. F., Zhang, W., Doherty, M., Ferguson, E., & Walsh, D. A. (2020, April). Mediators of the predictive relationship between a self-report measure of central mechanisms and future knee pain outcomes in the knee pain in the community (KPIC) cohort. Presented at OARSI 2020 World Congress, Vienna, Austria

Pain distant from the index site and sensitization in people with knee pain and low back pain
Presentation / Conference Contribution
Akin-Akinyosoye, K., Georgopoulos, V., Frowd, N., Swaithes, L., Stocks, J., Fernandes, G. S., Valdes, A., McWilliams, D., Zhang, W., Doherty, M., Ferguson, E., & Walsh, D. (2020, April). Pain distant from the index site and sensitization in people with knee pain and low back pain. Presented at OARSI 2020 World Congress, Vienna, Austria

P073 Comparative effectiveness of different exercise interventions on central sensitisation indices in humans: A systematic review and network meta-analysis
Presentation / Conference Contribution
Abd Elkhabir, A. A., McWilliams, D. F., Smith, S., Chaplin, W., Salimian, M., Georgopoulos, V., Kouraki, A., & Walsh, D. A. (2023, April). P073 Comparative effectiveness of different exercise interventions on central sensitisation indices in humans: A systematic review and network meta-analysis. Presented at British Society for Rheumatology Annual Conference 2023, Manchester

Background/Aims

Exercise has shown a promising effect in reducing central sensitisation (CS), but it is unknown which exercise type is the most effective. This review aimed to rank and compare the effectiveness of different exercise interventions... Read More about P073 Comparative effectiveness of different exercise interventions on central sensitisation indices in humans: A systematic review and network meta-analysis.