Hyperlipidaemia alone and in combination with acidosis can increase the incidence and severity of statin-induced myotoxicity

Taha, Dhiaa A.; Zgair, Atheer; Lee, Jong Bong; de Moor, Cornelia H.; Barrett, David A.; Bruce, Kimberley D.; Sungelo, Mitchell; Eckel, Robert H.; Gershkovich, Pavel

doi:10.1016/j.ejps.2017.01.018

All Outputs (3)

Development of cordycepin formulations for preclinical and clinical studies (2017)
Journal Article

There is extensive literature on in vivo studies with cordycepin but these studies were generally conducted without validation of the various formulations, especially in terms of the solubility of cordycepin in the dosing vehicles used. Cordycepin is... Read More about Development of cordycepin formulations for preclinical and clinical studies.

Lung function associated gene Integrator Complex subunit 12 regulates protein synthesis pathways (2017)
Journal Article

BACKGROUND: Genetic studies of human lung function and Chronic Obstructive Pulmonary Disease have identified a highly significant and reproducible signal on 4q24. It remains unclear which of the two candidate genes within this locus may regulate lung... Read More about Lung function associated gene Integrator Complex subunit 12 regulates protein synthesis pathways.

Hyperlipidaemia alone and in combination with acidosis can increase the incidence and severity of statin-induced myotoxicity (2017)
Journal Article

The association of lipophilic statins with plasma lipoproteins in the presence of disturbed acid-base balance can modify the pharmacokinetics and tissue distribution of these drugs, resulting in alteration in their efficacy and toxicity profiles. The... Read More about Hyperlipidaemia alone and in combination with acidosis can increase the incidence and severity of statin-induced myotoxicity.