All Outputs (26)

In vitro degradation of a chitosan-based osteochondral construct points to a transient effect on cellular viability (2024)
Journal Article
Pitrolino, K., Felfel, R., Roberts, G., Scotchford, C., Grant, D., & Sottile, V. (2024). In vitro degradation of a chitosan-based osteochondral construct points to a transient effect on cellular viability. Biomedical Materials, 19(5), Article 055025. https://doi.org/10.1088/1748-605x/ad6547

Bioresorbable chitosan scaffolds have shown potential for osteochondral repair applications. The in vivo degradation of chitosan, mediated by lysozyme and releasing glucosamine, enables progressive replacement by ingrowing tissue. Here the degradatio... Read More about In vitro degradation of a chitosan-based osteochondral construct points to a transient effect on cellular viability.

Functional performance of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold: a pre-clinical in vitro tribological study (2024)
Journal Article
Cowie, R. M., Macri-Pellizzeri, L., McLaren, J., Sanderson, W. J., Felfel, R. M., Scotchford, C. A., Scammell, B. E., Grant, D. M., Sottile, V., & Jennings, L. M. (2024). Functional performance of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold: a pre-clinical in vitro tribological study. Royal Society Open Science, 11(1), Article 230431. https://doi.org/10.1098/rsos.230431

Osteochondral grafts are used for repair of focal osteochondral lesions. Autologous grafts are the gold standard treatment; however, limited graft availability and donor site morbidity restrict use. Therefore, there is a clinical need for different g... Read More about Functional performance of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold: a pre-clinical in vitro tribological study.

Developing Porous Ortho- and Pyrophosphate-Containing Glass Microspheres; Structural and Cytocompatibility Characterisation (2022)
Journal Article
Milborne, B., Murrell, L., Cardillo-Zallo, I., Titman, J., Briggs, L., Scotchford, C., Thompson, A., Layfield, R., & Ahmed, I. (2022). Developing Porous Ortho- and Pyrophosphate-Containing Glass Microspheres; Structural and Cytocompatibility Characterisation. Bioengineering, 9(11), Article 611. https://doi.org/10.3390/bioengineering9110611

Phosphate-based glasses (PBGs) are promising materials for bone repair and regeneration as they can be formulated to be compositionally similar to the inorganic components of bone. Alterations to the PBG formulation can be used to tailor their degrad... Read More about Developing Porous Ortho- and Pyrophosphate-Containing Glass Microspheres; Structural and Cytocompatibility Characterisation.

Development and in vitro assessment of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold (2022)
Journal Article
Pitrolino, K. A., Felfel, R. M., Pellizzeri, L. M., McLaren, J., Popov, A. A., Sottile, V., Scotchford, C. A., Scammell, B. E., Roberts, G. A., & Grant, D. M. (2022). Development and in vitro assessment of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold. Carbohydrate Polymers, 282, Article 119126. https://doi.org/10.1016/j.carbpol.2022.119126

An innovative approach was developed to engineer a multi-layered chitosan scaffold for osteochondral defect repair. A combination of freeze drying and porogen-leaching out methods produced a porous, bioresorbable scaffold with a distinct gradient of... Read More about Development and in vitro assessment of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold.

Evaluating the cytotoxicity of Ge–Sb–Se chalcogenide glass optical fibres on 3T3 mouse fibroblasts (2021)
Journal Article
Mabwa, D., Kubiena, T., Parnell, H., Su, R., Furniss, D., Tang, Z., Leach, R., Benson, T. M., Scotchford, C. A., & Seddon, A. B. (2021). Evaluating the cytotoxicity of Ge–Sb–Se chalcogenide glass optical fibres on 3T3 mouse fibroblasts. RSC Advances, 11(15), 8682-8693. https://doi.org/10.1039/d0ra00353k

In vivo cancer detection based on the mid-infrared molecular fingerprint of tissue is promising for the fast diagnosis and treatment of suspected cancer patients. Few materials are mid-infrared transmissive, even fewer, which can be converted into fu... Read More about Evaluating the cytotoxicity of Ge–Sb–Se chalcogenide glass optical fibres on 3T3 mouse fibroblasts.

In-vitro cell interaction and apatite forming ability in simulated body fluid of ICIE16 and 13-93 bioactive glass coatings deposited by an emerging suspension high velocity oxy fuel (SHVOF) thermal spray (2020)
Journal Article
Bano, S., Romero, A. R., Grant, D., Nommeots-Nomm, A., Scotchford, C., Ahmed, I., & Hussain, T. (2021). In-vitro cell interaction and apatite forming ability in simulated body fluid of ICIE16 and 13-93 bioactive glass coatings deposited by an emerging suspension high velocity oxy fuel (SHVOF) thermal spray. Surface and Coatings Technology, 407, Article 126764. https://doi.org/10.1016/j.surfcoat.2020.126764

ICIE16 and 13-93 bioactive glasses have been proposed as alternative chemically stable compositions in physiological fluid keeping bioactivity comparable to Bioglass®. ICIE16 and 13-93 bioactive glasses coatings were produced via an emerging suspensi... Read More about In-vitro cell interaction and apatite forming ability in simulated body fluid of ICIE16 and 13-93 bioactive glass coatings deposited by an emerging suspension high velocity oxy fuel (SHVOF) thermal spray.

Metallic skeleton promoted two-phase durable icephobic layers (2020)
Journal Article
Wang, J., Wu, M., Liu, J., Xu, F., Hussain, T., Scotchford, C., & Hou, X. (2021). Metallic skeleton promoted two-phase durable icephobic layers. Journal of Colloid and Interface Science, 587, 47-55. https://doi.org/10.1016/j.jcis.2020.12.027

Hypothesis: The accretion of ice on component surfaces often causes severe impacts or accidents in modern industries. Applying icephobic surface is considered as an effective solution to minimise the hazards. However, the durability of the current ic... Read More about Metallic skeleton promoted two-phase durable icephobic layers.

Production of High Silicon-Doped Hydroxyapatite Thin Film Coatings via Magnetron Sputtering: Deposition, Characterisation, and In Vitro Biocompatibility (2020)
Journal Article
Coe, S. C., Wadge, M. D., Felfel, R. M., Ahmed, I., Walker, G. S., Scotchford, C. A., & Grant, D. M. (2020). Production of High Silicon-Doped Hydroxyapatite Thin Film Coatings via Magnetron Sputtering: Deposition, Characterisation, and In Vitro Biocompatibility. Coatings, 10(2), Article 190. https://doi.org/10.3390/coatings10020190

In recent years, it has been found that small weight percent additions of silicon to HA can be used to enhance the initial response between bone tissue and HA. A large amount of research has been concerned with bulk materials, however, only recently... Read More about Production of High Silicon-Doped Hydroxyapatite Thin Film Coatings via Magnetron Sputtering: Deposition, Characterisation, and In Vitro Biocompatibility.

Preclinical biological and physicochemical evaluation of two-photon engineered 3D biomimetic copolymer scaffolds for bone healing (2020)
Journal Article
Kampleitner, C., Changi, K., Felfel, R. M., Scotchford, C. A., Sottile, V., Kluger, R., Hoffmann, O., Grant, D. M., & Epstein, M. M. (2020). Preclinical biological and physicochemical evaluation of two-photon engineered 3D biomimetic copolymer scaffolds for bone healing. Biomaterials Science, 8(6), 1683-1694. https://doi.org/10.1039/c9bm01827a

A major challenge in orthopedics is the repair of large non-union bone fractures. A promising therapy for this indication is the use of biodegradable bioinspired biomaterials that stabilize the fracture site, relieve pain and initiate bone formation... Read More about Preclinical biological and physicochemical evaluation of two-photon engineered 3D biomimetic copolymer scaffolds for bone healing.

Effect of surface adsorption on icing behaviour of metallic coating (2019)
Journal Article
Wang, J., Memon, H., Liu, J., Yang, G., Xu, F., Hussain, T., Scotchford, C., & Hou, X. (2019). Effect of surface adsorption on icing behaviour of metallic coating. Surface and Coatings Technology, 380, Article 125068. https://doi.org/10.1016/j.surfcoat.2019.125068

Icephobicity of materials has received intensive attention in recent years due to the increasing requirement of ice protection in aerospace, wind energy and power lines. However, the influencing factors of material icephobicity have not been well ide... Read More about Effect of surface adsorption on icing behaviour of metallic coating.

Impact of Serum Source on Human Mesenchymal Stem Cell Osteogenic Differentiation in Culture (2019)
Journal Article
Popov, A., Scotchford, C., Grant, D., & Sottile, V. (2019). Impact of Serum Source on Human Mesenchymal Stem Cell Osteogenic Differentiation in Culture. International Journal of Molecular Sciences, 20(20), Article 5051. https://doi.org/10.3390/ijms20205051

Human mesenchymal stem cells (MSCs) show promise for musculoskeletal repair applications. Animal-derived serum is extensively used for MSC culture as a source of nutrients, extracellular matrix proteins and growth factors. However, the routine use of... Read More about Impact of Serum Source on Human Mesenchymal Stem Cell Osteogenic Differentiation in Culture.

Integrated multi-assay culture model for stem cell chondrogenic differentiation (2019)
Journal Article
Prosser, A., Scotchford, C., Roberts, G., Grant, D., & Sottile, V. (2019). Integrated multi-assay culture model for stem cell chondrogenic differentiation. International Journal of Molecular Sciences, 20(4), Article 951. https://doi.org/10.3390/ijms20040951

Recent osteochondral repair strategies highlight the promise of mesenchymal progenitors, an accessible stem cell source with osteogenic and chondrogenic potential, used in conjunction with biomaterials for tissue engineering. For this, regenerative m... Read More about Integrated multi-assay culture model for stem cell chondrogenic differentiation.

In vitro cellular testing of Strontium/Calcium substituted phosphate glass discs and microspheres shows potential for bone regeneration (2019)
Journal Article
Patel, U., Macri-Pellizzeri, L., Hossain, K. M. Z., Scammell, B. E., Grant, D. M., Scotchford, C. A., Hannon, A. C., Kennedy, A. R., Barney, E. R., Ahmed, I., & Sottile, V. (2019). In vitro cellular testing of Strontium/Calcium substituted phosphate glass discs and microspheres shows potential for bone regeneration. Journal of Tissue Engineering and Regenerative Medicine, 13(3), 396-405. https://doi.org/10.1002/term.2796

Phosphate glasses (PBG) are ideal materials for regenerative medicine strategies since their composition, degradation rates and ion release profiles can easily be controlled. Strontium has previously been found to simultaneously affect bone resorptio... Read More about In vitro cellular testing of Strontium/Calcium substituted phosphate glass discs and microspheres shows potential for bone regeneration.

Computational mechanical characterization of geometrically transformed Schwarz P lattice tissue scaffolds fabricated via two photon polymerization (2PP) (2018)
Journal Article
Zabidi, A. Z., Li, S., Felfel, R. M., Thomas, K. G., Grant, D. M., Mcnally, D., & Scotchford, C. (2019). Computational mechanical characterization of geometrically transformed Schwarz P lattice tissue scaffolds fabricated via two photon polymerization (2PP). Additive Manufacturing, 25, 399-411. https://doi.org/10.1016/j.addma.2018.11.021

Schwarz P unit cell-based tissue scaffolds comprised of poly(D,L-lactide-co-caprolactone)(PLCL) fabricated via the additive manufacturing technique, two-photon polymerisation (2PP) were found to undergo geometrical transformations from the original i... Read More about Computational mechanical characterization of geometrically transformed Schwarz P lattice tissue scaffolds fabricated via two photon polymerization (2PP).

Performance of multiphase scaffolds for bone repair based on two-photon polymerized poly(d,l-lactide-co-ɛ-caprolactone), recombinamers hydrogel and nano-HA (2018)
Journal Article
Felfel, R. M., Gupta, D., Zabidi, A. Z., Prosser, A., Scotchford, C. A., Sottile, V., & Grant, D. M. (2018). Performance of multiphase scaffolds for bone repair based on two-photon polymerized poly(d,l-lactide-co-ɛ-caprolactone), recombinamers hydrogel and nano-HA. Materials and Design, 160, 455-467. https://doi.org/10.1016/j.matdes.2018.09.035

Multiphase hybrids were fabricated from poly(d,l-lactide-co-ɛ-caprolactone) (PLCL) copolymer scaffolds impregnated with silk-elastin-like recombinamers (SELRs) hydrogel containing 2 wt% hydroxyapatite nanoparticles (nHA). The PLCL scaffolds, triply-p... Read More about Performance of multiphase scaffolds for bone repair based on two-photon polymerized poly(d,l-lactide-co-ɛ-caprolactone), recombinamers hydrogel and nano-HA.

Investigation on time-dependent wetting behavior of Ni-Cu-P ternary coating (2018)
Journal Article
Wang, J., Liu, J., Neate, N. C., Bai, M., Xu, F., Hussain, T., Scotchford, C., & Hou, X. (2018). Investigation on time-dependent wetting behavior of Ni-Cu-P ternary coating. Journal of Alloys and Compounds, 765, https://doi.org/10.1016/j.jallcom.2018.06.239

Hydrophobic metallic coatings have attracted increasing interest in the recent years due to their excellent mechanical durability. But the wetting behavior and hydrophobic mechanism of metallic coatings are far from clear. In this work, Ni-Cu-P terna... Read More about Investigation on time-dependent wetting behavior of Ni-Cu-P ternary coating.

Laser sintering of nano-hydroxyapatite coated polyamide 12 powders (2018)
Journal Article
Hui, D., Goodridge, R. D., Scotchford, C., & Grant, D. M. (2018). Laser sintering of nano-hydroxyapatite coated polyamide 12 powders. Additive Manufacturing, 22, 560-570. https://doi.org/10.1016/j.addma.2018.05.045

As part of a larger study on the laser sintering (LS) of nano-composite structures for biomedical applications, a wet mixing method was used to coat Polyamide 12 (PA12) particles with nano-hydroxyapatite (nHA). The addition of nHA significantly affec... Read More about Laser sintering of nano-hydroxyapatite coated polyamide 12 powders.

Single solvent based film casting method for the production of porous polymer films (2018)
Journal Article
Hossain, K. M. Z., Felfel, R. M., Ogbilikana, P. S., Thakker, D., Grant, D. M., Scotchford, C., & Ahmed, I. (2018). Single solvent based film casting method for the production of porous polymer films. Macromolecular Materials and Engineering, 303, https://doi.org/10.1002/mame.201700628

A single solvent based film casting process for fabricating porous polymer films was developed in this study. The porous film was produced by mixing concentrated polylactic acid/ chloroform solution (20 wt%) and fresh chloroform solvent followed by f... Read More about Single solvent based film casting method for the production of porous polymer films.

In vitro degradation and mechanical properties of PLA-PCL copolymer unit cell scaffolds generated by two-photon polymerization (2016)
Journal Article
Felfel, R. M., Poocza, L., Gimeno-Fabra, M., Milde, T., Hildebrand, G., Ahmed, I., Scotchford, C., Sottile, V., Grant, D. M., & Liefeith, K. (2016). In vitro degradation and mechanical properties of PLA-PCL copolymer unit cell scaffolds generated by two-photon polymerization. Biomedical Materials, 11(1), Article 015011. https://doi.org/10.1088/1748-6041/11/1/015011

© 2016 IOP Publishing Ltd. The manufacture of 3D scaffolds with specific controlled porous architecture, defined microstructure and an adjustable degradation profile was achieved using two-photon polymerization (TPP) with a size of 2 × 4 × 2 mm3. Sca... Read More about In vitro degradation and mechanical properties of PLA-PCL copolymer unit cell scaffolds generated by two-photon polymerization.

Oxidation state of a polyurethane membrane after plasma etching (2014)
Journal Article
Moles, M. D., Scotchford, C. A., & Campbell Ritchie, A. (2014). Oxidation state of a polyurethane membrane after plasma etching. 00 Journal not listed, 2014, Article 347979. https://doi.org/10.1155/2014/347979

Low moduli cell culture substrates can be used to apply dynamic mechanical strain to cells, by surface deformation. Understanding the surface interaction with cells is critical to improving cell adhesion and normal growth. A medical grade polyurethan... Read More about Oxidation state of a polyurethane membrane after plasma etching.