Computational mechanical characterization of geometrically transformed Schwarz P lattice tissue scaffolds fabricated via two photon polymerization (2PP)

Zabidi, Adi Z.; Li, Shuguang; Felfel, Reda M.; Thomas, Kathryn G.; Grant, David M; Mcnally, Donal; Scotchford, Colin

Abstract

Schwarz P unit cell-based tissue scaffolds comprised of poly(D,L-lactide-co-caprolactone)(PLCL) fabricated via the additive manufacturing technique, two-photon polymerisation (2PP) were found to undergo geometrical transformations from the original input design. A Schwarz P unit cell surface geometry CAD model was reconstructed to take into account the geometrical transformations through CAD modeling techniques using measurements obtained from an image-based averaging technique before its implementation for micromechanical analysis. Effective modulus results obtained from computational mechanical characterization via micromechanical analysis of the reconstructed unit cell assigned with the same material model making up the fabricated scaffolds demonstrated excellent agreement with a small margin of error at 6.94% from the experimental mean modulus (0.69 0.29MPa). The possible sources for the occurrence of geometrical transformations are discussed in this paper. The interrelationships between different dimensional parameters making up the Schwarz P architecture and resulting effective modulus are also assessed and discussed. With the ability to accommodate the geometrical transformations, maintain efficiency in terms of time and computational resources, micromechanical analysis has the potential to be implemented in tissue scaffolds with a periodic microstructure as well as other structures outside the field of tissue engineering in general.

Citation

Zabidi, A. Z., Li, S., Felfel, R. M., Thomas, K. G., Grant, D. M., Mcnally, D., & Scotchford, C. (2019). Computational mechanical characterization of geometrically transformed Schwarz P lattice tissue scaffolds fabricated via two photon polymerization (2PP). Additive Manufacturing, 25, 399-411. https://doi.org/10.1016/j.addma.2018.11.021

• Journal Article Type: Article
• Acceptance Date: Nov 17, 2018
• Online Publication Date: Nov 22, 2018
• Publication Date: Jan 31, 2019
• Deposit Date: Nov 22, 2018
• Publicly Available Date: Nov 23, 2019
• Journal: Additive Manufacturing
• Print ISSN: 2214-7810
• Electronic ISSN: 2214-8604
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 25
• Pages: 399-411
• DOI: https://doi.org/10.1016/j.addma.2018.11.021
• Keywords: Tissue scaffold; Schwarz P TPMS structure; Two-photon polymerization (2PP); Micromechanical analysis; Beam bending; Column buckling
• Public URL: https://nottingham-repository.worktribe.com/output/1300306
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S2214860418307085
• Additional Information: This article is maintained by: Elsevier; Article Title: Computational mechanical characterization of geometrically transformed Schwarz P lattice tissue scaffolds fabricated via two photon polymerization (2PP); Journal Title: Additive Manufacturing; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.addma.2018.11.021; Content Type: article; Copyright: © 2018 The Authors. Published by Elsevier B.V.
• Contract Date: Nov 22, 2018