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Oxidation state of a polyurethane membrane after plasma etching

Moles, Matthew D.; Scotchford, Colin A.; Campbell Ritchie, Alastair

Authors

Matthew D. Moles

Colin A. Scotchford

Alastair Campbell Ritchie



Abstract

Low moduli cell culture substrates can be used to apply dynamic mechanical strain to cells, by surface deformation. Understanding the surface interaction with cells is critical to improving cell adhesion and normal growth. A medical grade polyurethane (PU), Chronoflex AL 80A, was modified by oxygen plasma etching and characterised by X-ray photoelectron spectroscopy. Etching resulted in increased cross-linking at the isocyanate bond and formation of new oxygen moieties. The model, derived from patent data and XPS data of the unetched PU, indicated that the additional oxygen was likely to be hydroxyl and carbonyl groups. Etched membranes enhanced protein adhesion, resulting in full surface coverage compared to unetched PU. The etched PU supported cell adhesion and spreading, while the unetched PU was not conducive to monolayer formation.

Journal Article Type Article
Publication Date Apr 8, 2014
Journal Conference Papers in Science
Electronic ISSN 2356-6108
Peer Reviewed Peer Reviewed
Volume 2014
Article Number 347979
APA6 Citation Moles, M. D., Scotchford, C. A., & Campbell Ritchie, A. (2014). Oxidation state of a polyurethane membrane after plasma etching. 00 Journal not listed, 2014, https://doi.org/10.1155/2014/347979
DOI https://doi.org/10.1155/2014/347979
Publisher URL https://www.hindawi.com/archive/2014/347979/
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
Additional Information This Conference Paper is based on a presentation given by Matthew D. Moles at “UK Society for Biomaterials Annual Conference 2013” held from 24 June 2013 to 25 June 2013 in Birmingham, United Kingdom.

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