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Functional performance of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold: a pre-clinical in vitro tribological study (2024)
Journal Article
Cowie, R. M., Macri-Pellizzeri, L., McLaren, J., Sanderson, W. J., Felfel, R. M., Scotchford, C. A., …Jennings, L. M. (2024). Functional performance of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold: a pre-clinical in vitro tribological study. Royal Society Open Science, 11(1), Article 230431. https://doi.org/10.1098/rsos.230431

Osteochondral grafts are used for repair of focal osteochondral lesions. Autologous grafts are the gold standard treatment; however, limited graft availability and donor site morbidity restrict use. Therefore, there is a clinical need for different g... Read More about Functional performance of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold: a pre-clinical in vitro tribological study.

Evaluating the cytotoxicity of Ge–Sb–Se chalcogenide glass optical fibres on 3T3 mouse fibroblasts (2021)
Journal Article
Mabwa, D., Kubiena, T., Parnell, H., Su, R., Furniss, D., Tang, Z., …Seddon, A. B. (2021). Evaluating the cytotoxicity of Ge–Sb–Se chalcogenide glass optical fibres on 3T3 mouse fibroblasts. RSC Advances, 11(15), 8682-8693. https://doi.org/10.1039/d0ra00353k

In vivo cancer detection based on the mid-infrared molecular fingerprint of tissue is promising for the fast diagnosis and treatment of suspected cancer patients. Few materials are mid-infrared transmissive, even fewer, which can be converted into fu... Read More about Evaluating the cytotoxicity of Ge–Sb–Se chalcogenide glass optical fibres on 3T3 mouse fibroblasts.

In-vitro cell interaction and apatite forming ability in simulated body fluid of ICIE16 and 13-93 bioactive glass coatings deposited by an emerging suspension high velocity oxy fuel (SHVOF) thermal spray (2020)
Journal Article
Bano, S., Romero, A. R., Grant, D., Nommeots-Nomm, A., Scotchford, C., Ahmed, I., & Hussain, T. (2021). In-vitro cell interaction and apatite forming ability in simulated body fluid of ICIE16 and 13-93 bioactive glass coatings deposited by an emerging suspension high velocity oxy fuel (SHVOF) thermal spray. Surface and Coatings Technology, 407, Article 126764. https://doi.org/10.1016/j.surfcoat.2020.126764

ICIE16 and 13-93 bioactive glasses have been proposed as alternative chemically stable compositions in physiological fluid keeping bioactivity comparable to Bioglass®. ICIE16 and 13-93 bioactive glasses coatings were produced via an emerging suspensi... Read More about In-vitro cell interaction and apatite forming ability in simulated body fluid of ICIE16 and 13-93 bioactive glass coatings deposited by an emerging suspension high velocity oxy fuel (SHVOF) thermal spray.

Impact of Serum Source on Human Mesenchymal Stem Cell Osteogenic Differentiation in Culture (2019)
Journal Article
Popov, A., Scotchford, C., Grant, D., & Sottile, V. (2019). Impact of Serum Source on Human Mesenchymal Stem Cell Osteogenic Differentiation in Culture. International Journal of Molecular Sciences, 20(20), Article 5051. https://doi.org/10.3390/ijms20205051

Human mesenchymal stem cells (MSCs) show promise for musculoskeletal repair applications. Animal-derived serum is extensively used for MSC culture as a source of nutrients, extracellular matrix proteins and growth factors. However, the routine use of... Read More about Impact of Serum Source on Human Mesenchymal Stem Cell Osteogenic Differentiation in Culture.

Integrated multi-assay culture model for stem cell chondrogenic differentiation (2019)
Journal Article
Prosser, A., Scotchford, C., Roberts, G., Grant, D., & Sottile, V. (2019). Integrated multi-assay culture model for stem cell chondrogenic differentiation. International Journal of Molecular Sciences, 20(4), Article 951. https://doi.org/10.3390/ijms20040951

Recent osteochondral repair strategies highlight the promise of mesenchymal progenitors, an accessible stem cell source with osteogenic and chondrogenic potential, used in conjunction with biomaterials for tissue engineering. For this, regenerative m... Read More about Integrated multi-assay culture model for stem cell chondrogenic differentiation.

Laser sintering of nano-hydroxyapatite coated polyamide 12 powders (2018)
Journal Article
Hui, D., Goodridge, R. D., Scotchford, C., & Grant, D. M. (2018). Laser sintering of nano-hydroxyapatite coated polyamide 12 powders. Additive Manufacturing, 22, 560-570. https://doi.org/10.1016/j.addma.2018.05.045

As part of a larger study on the laser sintering (LS) of nano-composite structures for biomedical applications, a wet mixing method was used to coat Polyamide 12 (PA12) particles with nano-hydroxyapatite (nHA). The addition of nHA significantly affec... Read More about Laser sintering of nano-hydroxyapatite coated polyamide 12 powders.

In vitro degradation and mechanical properties of PLA-PCL copolymer unit cell scaffolds generated by two-photon polymerization (2016)
Journal Article
Felfel, R. M., Poocza, L., Gimeno-Fabra, M., Milde, T., Hildebrand, G., Ahmed, I., …Liefeith, K. (2016). In vitro degradation and mechanical properties of PLA-PCL copolymer unit cell scaffolds generated by two-photon polymerization. Biomedical Materials, 11(1), Article 015011. https://doi.org/10.1088/1748-6041/11/1/015011

© 2016 IOP Publishing Ltd. The manufacture of 3D scaffolds with specific controlled porous architecture, defined microstructure and an adjustable degradation profile was achieved using two-photon polymerization (TPP) with a size of 2 × 4 × 2 mm3. Sca... Read More about In vitro degradation and mechanical properties of PLA-PCL copolymer unit cell scaffolds generated by two-photon polymerization.

Oxidation state of a polyurethane membrane after plasma etching (2014)
Journal Article
Moles, M. D., Scotchford, C. A., & Campbell Ritchie, A. (2014). Oxidation state of a polyurethane membrane after plasma etching. 00 Journal not listed, 2014, Article 347979. https://doi.org/10.1155/2014/347979

Low moduli cell culture substrates can be used to apply dynamic mechanical strain to cells, by surface deformation. Understanding the surface interaction with cells is critical to improving cell adhesion and normal growth. A medical grade polyurethan... Read More about Oxidation state of a polyurethane membrane after plasma etching.

Effect of Q-switched laser surface texturing of titanium on osteoblast cell response (2014)
Journal Article
Voisey, K., Scotchford, C., Martin, L., & Gill, H. (2014). Effect of Q-switched laser surface texturing of titanium on osteoblast cell response. Physics Procedia, 56, https://doi.org/10.1016/j.phpro.2014.08.027

Titanium and its alloys are important biomedical materials. It is known that the surface texture of implanted medical devices affects cell response. Control of cell response has the potential to enhance fixation of implants into bone and, in other ap... Read More about Effect of Q-switched laser surface texturing of titanium on osteoblast cell response.

Topographical and chemical effects of electrochemically assisted deposited hydroxyapatite coatings on osteoblast-like cells (2013)
Journal Article
Pegg, E. C., Matboli, F., Marriott, T., Khan, I., & Scotchford, C. (2014). Topographical and chemical effects of electrochemically assisted deposited hydroxyapatite coatings on osteoblast-like cells. Journal of Biomaterials Applications, 28(6), https://doi.org/10.1177/0885328213487410

A recently commercialised hydroxyapatite electrochemically assisted chemical deposition technique (BoneMaster) has been shown to induce increased bone apposition; whether this response is caused by the surface topography or chemistry is unknown. An i... Read More about Topographical and chemical effects of electrochemically assisted deposited hydroxyapatite coatings on osteoblast-like cells.

Transient serum exposure regimes to support dual differentiation of human mesenchymal stem cells (2012)
Journal Article
France, L., Scotchford, C., Grant, D., Rashidi, H., Popov, A., & Sottile, V. (2014). Transient serum exposure regimes to support dual differentiation of human mesenchymal stem cells. Journal of Tissue Engineering and Regenerative Medicine, 8(8), https://doi.org/10.1002/term.1567

Human mesenchymal stem cells (MSCs), which can generate both osteoblasts and chondrocytes, represent an ideal resource for orthopaedic repair using tissue-engineering approaches. One major difficulty for the development of osteochondral constructs us... Read More about Transient serum exposure regimes to support dual differentiation of human mesenchymal stem cells.

Influence of screw holes and gamma sterilization on properties of phosphate glass fiber-reinforced composite bone plates (2011)
Journal Article
Han, N., Ahmed, I., Parsons, A. J., Harper, L., Scotchford, C. A., Scammell, B. E., & Rudd, C. D. (2013). Influence of screw holes and gamma sterilization on properties of phosphate glass fiber-reinforced composite bone plates. Journal of Biomaterials Applications, 27(8), 990-1002. https://doi.org/10.1177/0885328211431855

Polymers prepared from polylactic acid (PLA) have found a multitude of uses as medical devices. For a material that degrades, the main advantage is that an implant would not necessitate a second surgical event for removal. In this study, fibers produ... Read More about Influence of screw holes and gamma sterilization on properties of phosphate glass fiber-reinforced composite bone plates.

Scanning electron microscopy of biomaterials (2004)
Book Chapter
McKinlay, K., Scotchford, C., Grant, D., Oliver, J., King, J. R., & Brown, P. D. (2004). Scanning electron microscopy of biomaterials. In S. McVitie, & D. McComb (Eds.), Electron Microscopy and Analysis 2003: Proceedings of the Institute of Physics Electron Microscopy and Analysis Group Conference, University of Oxford, 3-5 September 2003. Institute of Physics Publishing

A comparison of conventional high vacuum scanning electron microscopy (HVSEM), environmental SEM (ESEM) and confocal laser scanning microscopy (CLSM) in the assessment of cell-material interactions is made. The processing of cells cultured for conven... Read More about Scanning electron microscopy of biomaterials.