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Topographical and chemical effects of electrochemically assisted deposited hydroxyapatite coatings on osteoblast-like cells

Pegg, Elise C.; Matboli, Faisal; Marriott, Tim; Khan, Imran; Scotchford, Colin

Authors

Elise C. Pegg

Faisal Matboli

Tim Marriott

Imran Khan

Colin Scotchford

Abstract

A recently commercialised hydroxyapatite electrochemically assisted chemical deposition technique (BoneMaster) has been shown to induce increased bone apposition; whether this response is caused by the surface topography or chemistry is unknown. An in-vitro examination using human osteoblast-like cells was performed on a series of BoneMaster-coated surfaces. The chemistry was separated from the topography using a thin gold coating; Thermanox coverslips were used as a control. BoneMaster surfaces showed significantly greater alkaline phosphatase activity and osteocalcin production compared with controls; however, no difference was found between the gold-coated and uncoated BoneMaster samples, indicating topography is the main contributing factor.

Journal Article Type Article
Publication Date Feb 1, 2014
Journal Journal of Biomaterials Applications
Print ISSN 0885-3282
Electronic ISSN 1530-8022
Publisher SAGE Publications (UK and US)
Peer Reviewed Peer Reviewed
Volume 28
Issue 6
Institution Citation Pegg, E. C., Matboli, F., Marriott, T., Khan, I., & Scotchford, C. (2014). Topographical and chemical effects of electrochemically assisted deposited hydroxyapatite coatings on osteoblast-like cells. Journal of Biomaterials Applications, 28(6), doi:10.1177/0885328213487410
DOI https://doi.org/10.1177/0885328213487410
Keywords Fixation, hydroxyapatite, bone, topography, chemistry, surface
Publisher URL http://journals.sagepub.com/doi/10.1177/0885328213487410
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf




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