Topographical and chemical effects of electrochemically assisted deposited hydroxyapatite coatings on osteoblast-like cells

Pegg, Elise C.; Matboli, Faisal; Marriott, Tim; Khan, Imran; Scotchford, Colin

Abstract

A recently commercialised hydroxyapatite electrochemically assisted chemical deposition technique (BoneMaster) has been shown to induce increased bone apposition; whether this response is caused by the surface topography or chemistry is unknown. An in-vitro examination using human osteoblast-like cells was performed on a series of BoneMaster-coated surfaces. The chemistry was separated from the topography using a thin gold coating; Thermanox coverslips were used as a control. BoneMaster surfaces showed significantly greater alkaline phosphatase activity and osteocalcin production compared with controls; however, no difference was found between the gold-coated and uncoated BoneMaster samples, indicating topography is the main contributing factor.

Citation

Pegg, E. C., Matboli, F., Marriott, T., Khan, I., & Scotchford, C. (2014). Topographical and chemical effects of electrochemically assisted deposited hydroxyapatite coatings on osteoblast-like cells. Journal of Biomaterials Applications, 28(6), https://doi.org/10.1177/0885328213487410

• Journal Article Type: Article
• Acceptance Date: Mar 21, 2013
• Online Publication Date: May 15, 2013
• Publication Date: Feb 1, 2014
• Deposit Date: Aug 15, 2017
• Publicly Available Date: Aug 15, 2017
• Journal: Journal of Biomaterials Applications
• Print ISSN: 0885-3282
• Electronic ISSN: 1530-8022
• Publisher: SAGE Publications
• Peer Reviewed: Peer Reviewed
• Volume: 28
• Issue: 6
• DOI: https://doi.org/10.1177/0885328213487410
• Keywords: Fixation, hydroxyapatite, bone, topography, chemistry, surface
• Public URL: https://nottingham-repository.worktribe.com/output/720735
• Publisher URL: http://journals.sagepub.com/doi/10.1177/0885328213487410
• Contract Date: Aug 15, 2017