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Topographical and chemical effects of electrochemically assisted deposited hydroxyapatite coatings on osteoblast-like cells

Pegg, Elise C.; Matboli, Faisal; Marriott, Tim; Khan, Imran; Scotchford, Colin

Authors

Elise C. Pegg

Faisal Matboli

Tim Marriott

Imran Khan



Abstract

A recently commercialised hydroxyapatite electrochemically assisted chemical deposition technique (BoneMaster) has been shown to induce increased bone apposition; whether this response is caused by the surface topography or chemistry is unknown. An in-vitro examination using human osteoblast-like cells was performed on a series of BoneMaster-coated surfaces. The chemistry was separated from the topography using a thin gold coating; Thermanox coverslips were used as a control. BoneMaster surfaces showed significantly greater alkaline phosphatase activity and osteocalcin production compared with controls; however, no difference was found between the gold-coated and uncoated BoneMaster samples, indicating topography is the main contributing factor.

Citation

Pegg, E. C., Matboli, F., Marriott, T., Khan, I., & Scotchford, C. (2014). Topographical and chemical effects of electrochemically assisted deposited hydroxyapatite coatings on osteoblast-like cells. Journal of Biomaterials Applications, 28(6), https://doi.org/10.1177/0885328213487410

Journal Article Type Article
Acceptance Date Mar 21, 2013
Online Publication Date May 15, 2013
Publication Date Feb 1, 2014
Deposit Date Aug 15, 2017
Publicly Available Date Aug 15, 2017
Journal Journal of Biomaterials Applications
Print ISSN 0885-3282
Electronic ISSN 1530-8022
Publisher SAGE Publications
Peer Reviewed Peer Reviewed
Volume 28
Issue 6
DOI https://doi.org/10.1177/0885328213487410
Keywords Fixation, hydroxyapatite, bone, topography, chemistry, surface
Public URL http://eprints.nottingham.ac.uk/id/eprint/44917
Publisher URL http://journals.sagepub.com/doi/10.1177/0885328213487410
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Pegg_2014_JBiomatAppl_Symplectic.pdf (861 Kb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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