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Scanning electron microscopy of biomaterials

McKinlay, K.J.; Scotchford, C.A.; Grant, D.M.; Oliver, J.M.; King, John R.; Brown, Paul D.

Authors

K.J. McKinlay

D.M. Grant

J.M. Oliver

John R. King

Paul D. Brown



Contributors

Stephen McVitie
Editor

David McComb
Editor

Abstract

A comparison of conventional high vacuum scanning electron microscopy (HVSEM), environmental SEM (ESEM) and confocal laser scanning microscopy (CLSM) in the assessment of cell-material interactions is made. The processing of cells cultured for conventional HVSEM leads to the loss of morphological features that are retained when using ESEM. The use of ESEM in conjunction with CLSM of the labeled cytoskeleton gives an indication of changes to the cell morphology as a consequence of incubation time and substrate surface features.

Citation

McKinlay, K., Scotchford, C., Grant, D., Oliver, J., King, J. R., & Brown, P. D. (2004). Scanning electron microscopy of biomaterials. In S. McVitie, & D. McComb (Eds.), Electron Microscopy and Analysis 2003: Proceedings of the Institute of Physics Electron Microscopy and Analysis Group Conference, University of Oxford, 3-5 September 2003. Institute of Physics Publishing

Publication Date Jan 1, 2004
Deposit Date Mar 25, 2011
Publicly Available Date Mar 28, 2024
Peer Reviewed Peer Reviewed
Issue 179
Series Title Institute of Physics conference series
Book Title Electron Microscopy and Analysis 2003: Proceedings of the Institute of Physics Electron Microscopy and Analysis Group Conference, University of Oxford, 3-5 September 2003
ISBN 750309679
Keywords SEM
ESEM
CLSM
Biomaterials
Public URL https://nottingham-repository.worktribe.com/output/1021674
Related Public URLs http://iopscience.iop.org/

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