All Outputs (69)

Motivation to Reduce Drinking and Engagement in Alcohol Misuse Treatment in Alcohol-Related Liver Disease: A National Health Survey (2021)
Journal Article

INTRODUCTION: The study aim was to identify predictors of motivation to reduce alcohol consumption and whether motivation predicts engagement in alcohol misuse treatment in alcohol-related liver disease (ALD). METHODS: Data from health surveys and he... Read More about Motivation to Reduce Drinking and Engagement in Alcohol Misuse Treatment in Alcohol-Related Liver Disease: A National Health Survey.

Incidence and survival of haemophagocytic lymphohistiocytosis: A population‐based cohort study from England (2021)
Journal Article

Background: Haemophagocytic lymphohistiocytosis (HLH) is a rare hyper-inflammatory condition with poor outcomes. Objectives: Few population-based estimates of the incidence and survival in adults exist. We aimed to provide these data for England. Met... Read More about Incidence and survival of haemophagocytic lymphohistiocytosis: A population‐based cohort study from England.

Impact of COVID-19 pandemic on prevalence of Clostridioides difficile infection in a UK tertiary centre (2021)
Journal Article

Serious concerns have been raised about a possible increase in cases of Clostridioides difficile infection (CDI) during the COVID-19 pandemic. We conducted a retrospective observational single centre study which revealed that total combined community... Read More about Impact of COVID-19 pandemic on prevalence of Clostridioides difficile infection in a UK tertiary centre.

Chest Radiograph Scoring Alone or Combined with Other Risk Scores for Predicting Outcomes in COVID-19 (2021)
Journal Article

Background Radiographic severity may help predict patient deterioration and outcomes from COVID-19 pneumonia. Purpose To assess the reliability and reproducibility of three chest radiograph reporting systems (radiographic assessment of lung edema [RA... Read More about Chest Radiograph Scoring Alone or Combined with Other Risk Scores for Predicting Outcomes in COVID-19.

Characterizing the risk interplay between alcohol intake and body mass index on cirrhosis morbidity (2021)
Journal Article

Background and Aims: It is thought that alcohol intake and body mass index (BMI) interact supra-additively to modulate the risk of cirrhosis, but evidence for this phenomenon is limited. We investigated the interrelationship between alcohol and BMI o... Read More about Characterizing the risk interplay between alcohol intake and body mass index on cirrhosis morbidity.

A validation study of the identification of haemophagocytic lymphohistiocytosis in England using population-based health data (2021)
Journal Article

We assessed the validity of coded healthcare data to identify cases of haemophagocytic lymphohistiocytosis (HLH). Hospital Episode Statistics (HES) identified 127 cases within five hospital Trusts 2013–2018 using ICD-10 codes D76.1, D76.2 and D76.3.... Read More about A validation study of the identification of haemophagocytic lymphohistiocytosis in England using population-based health data.

Socioeconomic inequalities in the incidence of alcohol-related liver disease: A nationwide Danish study (2021)
Journal Article

Background: There is socio-economic inequality in total alcohol-related harm, but knowledge of inequality in the incidence of specific alcohol-related diseases would be beneficial for prevention. Registry-based studies with nationwide coverage may re... Read More about Socioeconomic inequalities in the incidence of alcohol-related liver disease: A nationwide Danish study.

Planned surgery in the COVID-19 pandemic: a prospective cohort study from Nottingham (2021)
Journal Article

Purpose Globally planned surgical procedures have been deferred during the current COVID-19 pandemic. The study aimed to report the outcomes of planned urgent and cancer cases during the current pandemic using a multi-disciplinary prioritisation gro... Read More about Planned surgery in the COVID-19 pandemic: a prospective cohort study from Nottingham.

Outcomes after non-operative management of perforated diverticular disease: a population-based cohort study (2021)
Journal Article

BACKGROUND: The management of perforated diverticular disease has changed in the past 10 years with a move towards less surgical intervention. This population-based cohort study aimed to define the risk of death and readmission following non-operativ... Read More about Outcomes after non-operative management of perforated diverticular disease: a population-based cohort study.

COVID-19-associated hyperinflammation and escalation of patient care: a retrospective longitudinal cohort study (2020)
Journal Article

Background: A subset of patients with severe COVID-19 develop a hyperinflammatory syndrome, which might contribute to morbidity and mortality. This study explores a specific phenotype of COVID-19-associated hyperinflammation (COV-HI), and its associa... Read More about COVID-19-associated hyperinflammation and escalation of patient care: a retrospective longitudinal cohort study.

Incidence, prevalence and mortality of autoimmune hepatitis in England 1997-2015. A population-based cohort study (2020)
Journal Article

© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Background & Aims: There are few population-based studies of the incidence and mortality of autoimmune hepatitis. The burden of the disease and how it has changed over time have not... Read More about Incidence, prevalence and mortality of autoimmune hepatitis in England 1997-2015. A population-based cohort study.

Changes in the testing for and incidence of celiac disease in the UK 2005-2015: a population based cohort study (2019)
Journal Article

The diagnosis rates of coeliac disease differ substantially between countries. Intriguingly, there has been recent evidence from Olmstead County, USA and Finland that in the last 5-10 years incidence has plateaued or even declined. In most population... Read More about Changes in the testing for and incidence of celiac disease in the UK 2005-2015: a population based cohort study.

A validation study of the CirCom comorbidity score in an English cirrhosis population using the Clinical Practice Research Datalink (2018)
Journal Article

Purpose: The CirCom score has been developed from Danish data as a specific measure of comorbidity for cirrhosis to predict all-cause mortality. We compared its performance with the Charlson Comorbidity Index (CCI) in an English cirrhosis population.... Read More about A validation study of the CirCom comorbidity score in an English cirrhosis population using the Clinical Practice Research Datalink.

The risk of Clostridium difficile infection in patients with pernicious anaemia: a retrospective cohort study using primary care database. (2017)
Journal Article

Background: Studies have found an association between proton pump inhibitor (PPI) use and Clostridium difficile infection. The purpose of this study was to determine whether the mechanism by which PPIs induce an increased risk of C. difficile infecti... Read More about The risk of Clostridium difficile infection in patients with pernicious anaemia: a retrospective cohort study using primary care database..

Community acquired pneumonia incidence before and after proton pump inhibitor prescription: population based study (2016)
Journal Article

Objective To examine the risk of community acquired pneumonia before and after prescription of proton pump inhibitor (PPI) and assess whether unmeasured confounding explains this association. Design Cohort study and self controlled case series. S... Read More about Community acquired pneumonia incidence before and after proton pump inhibitor prescription: population based study.

The use of a bayesian hierarchy to develop and validate a co-morbidity score to predict mortality for linked primary and secondary care data from the NHS in England (2016)
Journal Article

Background: We have assessed whether the linkage between routine primary and secondary care records provided an opportunity to develop an improved population based co-morbidity score with the combined information on co-morbidities from both health ca... Read More about The use of a bayesian hierarchy to develop and validate a co-morbidity score to predict mortality for linked primary and secondary care data from the NHS in England.

Proton pump inhibitor prescribing patterns in the UK: a primary care database study (2016)
Journal Article

Purpose: To determine the prevalence and pattern of proton pump inhibitor (PPI) prescription and the practices employed to reduce PPI use in the UK general population. Methods: The UK's Clinical Practice Research Database was used to identify indi... Read More about Proton pump inhibitor prescribing patterns in the UK: a primary care database study.

The risk of community-acquired pneumonia among 9803 patients with coeliac disease compared to the general population: a cohort study (2016)
Journal Article

Background: Patients with coeliac disease are considered as individuals for whom pneumococcal vaccination is advocated. Aim: To quantify the risk of community-acquired pneumonia among patients with coeliac disease, assessing whether vaccination ag... Read More about The risk of community-acquired pneumonia among 9803 patients with coeliac disease compared to the general population: a cohort study.

When are breast cancer patients at highest risk of venous thromboembolism? A cohort study using English healthcare data (2015)
Journal Article

Breast cancer patients are at increased risk of VTE, particularly in the peri-diagnosis period. However, no previous epidemiological studies have investigated the relative impact of breast cancer treatments in a time-dependent manner. We aimed to det... Read More about When are breast cancer patients at highest risk of venous thromboembolism? A cohort study using English healthcare data.

Causes of death in people with liver cirrhosis in England compared to the general population: a population-based cohort study (2015)
Journal Article

Introduction Liver cirrhosis is increasing worldwide and associated with high mortality. Precise estimates of cause-specific mortality compared to the general population, by underlying aetiology, are lacking. Such information may demonstrate areas w... Read More about Causes of death in people with liver cirrhosis in England compared to the general population: a population-based cohort study.