All Outputs (10)

Is rat a good model for assessment of particulate-based taste-masked formulations? (2019)
Journal Article
Ali, J., Chiang, M., Lee, J. B., Voronin, G. O., Bennett, J., Cram, A., Kagan, L., Garnett, M. C., Roberts, C. J., & Gershkovich, P. (2020). Is rat a good model for assessment of particulate-based taste-masked formulations?. European Journal of Pharmaceutics and Biopharmaceutics, 146, 1-9. https://doi.org/10.1016/j.ejpb.2019.11.001

Recently there has been an increased interest to develop specialised dosage forms that are better suited to specific patient populations, such as paediatrics and geriatrics. In these patient populations the acceptability of the oral dosage form can b... Read More about Is rat a good model for assessment of particulate-based taste-masked formulations?.

Making tablets for delivery of poorly soluble drugs using photoinitiated 3D inkjet printing (2019)
Journal Article
Clark, E. A., Alexander, M. R., Irvine, D. J., Roberts, C. J., Wallace, M. J., Yoo, J., & Wildman, R. D. (2020). Making tablets for delivery of poorly soluble drugs using photoinitiated 3D inkjet printing. International Journal of Pharmaceutics, 578, Article 118805. https://doi.org/10.1016/j.ijpharm.2019.118805

© 2019 In this study, we investigate the viability of three-dimensional (3D) inkjet printing with UV curing to produce solid dosage forms containing a known poorly soluble drug, carvedilol. The formulation consists of 10 wt% carvedilol, Irgacure 2959... Read More about Making tablets for delivery of poorly soluble drugs using photoinitiated 3D inkjet printing.

Cetuximab-conjugated chitosan-pectinate (modified) composite nanoparticles for targeting colon cancer (2019)
Journal Article
Sabra, R., Billa, N., & Roberts, C. J. (2019). Cetuximab-conjugated chitosan-pectinate (modified) composite nanoparticles for targeting colon cancer. International Journal of Pharmaceutics, 572, Article 118775. https://doi.org/10.1016/j.ijpharm.2019.118775

© 2019 Elsevier B.V. In the present study, we successfully developed a cetuximab-conjugated modified citrus pectin-chitosan nanoparticles for targeted delivery of curcumin (Cet-MCPCNPs) for the treatment of colorectal cancer. In vitro analyses reveal... Read More about Cetuximab-conjugated chitosan-pectinate (modified) composite nanoparticles for targeting colon cancer.

Pharmacokinetics and tissue distribution of an orally administered mucoadhesive chitosan-coated amphotericin B-Loaded nanostructured lipid carrier (NLC) in rats (2019)
Journal Article
Ling, J. T. S., Roberts, C., & Billa, N. (2019). Pharmacokinetics and tissue distribution of an orally administered mucoadhesive chitosan-coated amphotericin B-Loaded nanostructured lipid carrier (NLC) in rats. Journal of Biomaterials Science, Polymer Edition, 31(2), 141-154. https://doi.org/10.1080/09205063.2019.1680926

© 2019 Informa UK Limited, trading as Taylor & Francis Group. Oral delivery of amphotericin B (AmpB) is desirable because it provides a more patient-friendly mode of administration compared to the current delivery approach akin with the marketed Am... Read More about Pharmacokinetics and tissue distribution of an orally administered mucoadhesive chitosan-coated amphotericin B-Loaded nanostructured lipid carrier (NLC) in rats.

High-throughput characterization of fluid properties to predict droplet ejection for three-dimensional inkjet printing formulations (2019)
Journal Article
Zhou, Z., Ruiz Cantu, L., Chen, X., Alexander, M. R., Roberts, C. J., Hague, R., Tuck, C., Irvine, D., & Wildman, R. (2019). High-throughput characterization of fluid properties to predict droplet ejection for three-dimensional inkjet printing formulations. Additive Manufacturing, 29, Article 100792. https://doi.org/10.1016/j.addma.2019.100792

Inkjet printing has been used as an Additive Manufacturing (AM) method to fabricate three-dimensional (3D) structures. However, a lack of materials suitable for inkjet printing poses one of the key challenges that impedes industry from fully adopting... Read More about High-throughput characterization of fluid properties to predict droplet ejection for three-dimensional inkjet printing formulations.

Nanofibrous scaffolds support a 3D in vitro permeability model of the human intestinal epitheleum (2019)
Journal Article
Patient, J. D., Hajiali, H., Harris, K., Abrahamsson, B., Tannergreen, C., White, L. J., Ghaemmaghami, A. M., Williams, P. M., Roberts, C. J., & Rose, F. R. (2019). Nanofibrous scaffolds support a 3D in vitro permeability model of the human intestinal epitheleum. Frontiers in Pharmacology, 10, Article 456. https://doi.org/10.3389/fphar.2019.00456

Advances in drug research not only depend on high throughput screening to evaluate large numbers of lead compounds but also on the development of in vitro models which can simulate human tissues in terms of drug permeability and functions. Potential... Read More about Nanofibrous scaffolds support a 3D in vitro permeability model of the human intestinal epitheleum.

Water-Based 3D Inkjet Printing of an Oral Pharmaceutical Dosage Form (2019)
Journal Article
Cader, H. K., Rance, G. A., Alexander, M. R., Gonçalves, A. D., Roberts, C. J., Tuck, C. J., & Wildman, R. D. (2019). Water-Based 3D Inkjet Printing of an Oral Pharmaceutical Dosage Form. International Journal of Pharmaceutics, 564, 359-368. https://doi.org/10.1016/j.ijpharm.2019.04.026

Inkjet printing is a form of additive manufacturing where liquid droplets are selectively deposited onto a substrate followed by solidification. The process provides significant potential advantages for producing solid oral dosage forms or tablets, i... Read More about Water-Based 3D Inkjet Printing of an Oral Pharmaceutical Dosage Form.

Antifungal and mucoadhesive properties of an orally administered chitosan-coated amphotericin B 1 nanostructured lipid carrier (NLC) (2019)
Journal Article
Ling, J. T. S., Roberts, C., & Billa, N. (2019). Antifungal and mucoadhesive properties of an orally administered chitosan-coated amphotericin B 1 nanostructured lipid carrier (NLC). AAPS PharmSciTech, 20(3), Article 136. https://doi.org/10.1208/s12249-019-1346-7

Surface - modified nanostructured lipid carriers (NLC) is a promising formulation to prolong the retention time of the therapeutic agent at the site of absorption. Chitosan-coated AmpB-loaded NLC (ChiAmpB NLC) were developed showing particle size of... Read More about Antifungal and mucoadhesive properties of an orally administered chitosan-coated amphotericin B 1 nanostructured lipid carrier (NLC).

Lipids and polymers in pharmaceutical technology: lifelong companions (2019)
Journal Article
Siepmann, J., Faham, A., Clas, S.-D., Boyd, B. J., Jannin, V., Bernkop-Schnürch, A., Zhao, H., Lecommandoux, S., Evans, J. C., Allen, C., Merkel, O. M., Costabile, G., Alexander, M. R., Wildman, R. D., Roberts, C. J., & Leroux, J.-C. (2019). Lipids and polymers in pharmaceutical technology: lifelong companions. International Journal of Pharmaceutics, 558, 128-142. https://doi.org/10.1016/j.ijpharm.2018.12.080

In pharmaceutical technology, lipids and polymers are considered pillar excipients for the fabrication of most dosage forms, irrespective of the administration route. They play various roles ranging from support vehicles to release rate modifiers, st... Read More about Lipids and polymers in pharmaceutical technology: lifelong companions.

Chemical Imaging of Buried Interfaces in Organic-Inorganic Devices Using Focused Ion Beam-Time-of-Flight-Secondary-Ion Mass Spectrometry (2019)
Journal Article
Tiddia, M., Mihara, I., Seah, M. P., Trindade, G. F., Kollmer, F., Roberts, C. J., Hague, R., Mula, G., Gilmore, I. S., & Havelund, R. (2019). Chemical Imaging of Buried Interfaces in Organic-Inorganic Devices Using Focused Ion Beam-Time-of-Flight-Secondary-Ion Mass Spectrometry. ACS Applied Materials and Interfaces, 11(4), 4500-4506. https://doi.org/10.1021/acsami.8b15091

Copyright © 2019 American Chemical Society. Organic-inorganic hybrid materials enable the design and fabrication of new materials with enhanced properties. The interface between the organic and inorganic materials is often critical to the device's pe... Read More about Chemical Imaging of Buried Interfaces in Organic-Inorganic Devices Using Focused Ion Beam-Time-of-Flight-Secondary-Ion Mass Spectrometry.