Skip to main content

Research Repository

Advanced Search

Antifungal and mucoadhesive properties of an orally administered chitosan-coated amphotericin B 1 nanostructured lipid carrier (NLC)

Ling, Janet Tan Sui; Roberts, Clive; Billa, Nashiru

Authors

Janet Tan Sui Ling

Nashiru Billa



Abstract

Surface - modified nanostructured lipid carriers (NLC) is a promising formulation to prolong the retention time of the therapeutic agent at the site of absorption. Chitosan-coated AmpB-loaded NLC (ChiAmpB NLC) were developed showing particle size of 394.4 ± 6.4 nm, encapsulation efficiency of 86.0 ± 0.3 % and a drug loading of 11.0 ± 0.1 %. ChiAmpB NLC showed biphasic release behaviour with no significant change in its physical properties upon exposure to conditions simulating the gastrointestinal tract. Compared to pure AmpB, ChiAmpB NLC observed not only a comparable antifungal behaviour but showed superior safety profiles, with two times lesser toxicity to the red blood cells and ten times safer to the HT-29 cell line. It was also successfully observed a translation of the in vitro mucoadhesion result to the ex vivo animal study in which ChiAmpB NLC results in higher percentage of retention in the small intestine compared to uncoated formulation. Together, the data strongly offered the possibility of having a non-toxic yet effective oral treatment for systemic fungal infections.

Journal Article Type Article
Publication Date Apr 1, 2019
Journal AAPS PharmSciTech
Electronic ISSN 1530-9932
Publisher American Association of Pharmaceutical Scientists
Peer Reviewed Peer Reviewed
Volume 20
Issue 3
Article Number 136
APA6 Citation Ling, J. T. S., Roberts, C., & Billa, N. (2019). Antifungal and mucoadhesive properties of an orally administered chitosan-coated amphotericin B 1 nanostructured lipid carrier (NLC). AAPS PharmSciTech, 20(3), https://doi.org/10.1208/s12249-019-1346-7
DOI https://doi.org/10.1208/s12249-019-1346-7
Keywords Agronomy and Crop Science; Ecology; Aquatic Science; Ecology, Evolution, Behavior and Systematics; Drug Discovery; Pharmaceutical Science; General Medicine
Publisher URL https://link.springer.com/article/10.1208%2Fs12249-019-1346-7
Related Public URLs https://link.springer.com/journal/12249
Additional Information The original publication is available at www.springerlink.com.

Collab paper with UNM.

Files







You might also like



Downloadable Citations

;