The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling

Matthews, Krystal L.; Coleman, Christopher M.; van der Meer, Yvonne; Snijder, Eric J.; Frieman, Matthew B.

doi:10.1099/vir.0.062059-0

All Outputs (6)

Treating MERS-CoV during an outbreak (2014)
Journal Article

Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection (2014)
Journal Article

Outbreaks of emerging infections present health professionals with the unique challenge of trying to select appropriate pharmacologic treatments in the clinic with little time available for drug testing and development. Typically, clinicians are left... Read More about Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection.

Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses (2014)
Journal Article

We have previously shown that SSYA10-001 blocks severe acute respiratory syndrome coronavirus (SARS-CoV) replication by inhibiting SARS-CoV helicase (nsp13). Here, we show that SSYA10-001 also inhibits replication of two other coronaviruses, mouse he... Read More about Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses.

Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice (2014)
Journal Article

Development of vaccination strategies for emerging pathogens are particularly challenging because of the sudden nature of their emergence and the long process needed for traditional vaccine development. Therefore, there is a need for development of a... Read More about Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice.

Coronaviruses: Important Emerging Human Pathogens (2014)
Journal Article

The identification of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 reaffirmed the importance of understanding how coronaviruses emerge, infect, and cause disease. By comparing what is known about severe acute respiratory syndrome c... Read More about Coronaviruses: Important Emerging Human Pathogens.

The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling (2014)
Journal Article

The recently emerged Middle East respiratory syndrome coronavirus (MERS-CoV), a betacoronavirus, is associated with severe pneumonia and renal failure. The environmental origin of MERS-CoV is as yet unknown; however, its genome sequence is closely re... Read More about The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling.