Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses

Weiss, Susan R.; Adedeji, Adeyemi O.; Singh, Kamalendra; Kassim, Ademola; Coleman, Christopher M.; Elliott, Ruth; Frieman, Matthew B.; Sarafianos, Stefan G.

Abstract

We have previously shown that SSYA10-001 blocks severe acute respiratory syndrome coronavirus (SARS-CoV) replication by inhibiting SARS-CoV helicase (nsp13). Here, we show that SSYA10-001 also inhibits replication of two other coronaviruses, mouse hepatitis virus (MHV) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). A putative binding pocket for SSYA10-001 was identified and shown to be similar in SARS-CoV, MERS-CoV, and MHV helicases. These studies show that it is possible to target multiple coronaviruses through broad-spectrum inhibitors. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

• Journal Article Type: Article
• Acceptance Date: May 14, 2014
• Online Publication Date: May 19, 2014
• Publication Date: 2014-08
• Deposit Date: Dec 17, 2019
• Journal: Antimicrobial Agents and Chemotherapy
• Print ISSN: 0066-4804
• Electronic ISSN: 1098-6596
• Publisher: American Society for Microbiology
• Peer Reviewed: Peer Reviewed
• Volume: 58
• Issue: 8
• Pages: 4894-4898
• DOI: https://doi.org/10.1128/AAC.02994-14
• Keywords: Pharmacology (medical); Pharmacology; Infectious Diseases
• Public URL: https://nottingham-repository.worktribe.com/output/3590238