Timing of high-dose methotrexate CNS prophylaxis in DLBCL: a multicenter international analysis of 1384 patients

Wilson, Matthew R.; Eyre, Toby A.; Kirkwood, Amy A.; Wong Doo, Nicole; Soussain, Carole; Choquet, Sylvain; Martinez-Calle, Nicolás; Preston, Gavin; Ahearne, Matthew; Schorb, Elisabeth; Moles-Moreau, Marie-Pierre; Ku, Matthew; Rusconi, Chiara; Khwaja, Jahanzaib; Narkhede, Mayur; Lewis, Katharine L.; Calimeri, Teresa; Durot, Eric; Renaud, Loïc; Øvlisen, Andreas Kiesbye; McIlroy, Graham; Ebsworth, Timothy J.; Elliot, Johnathan; Santarsieri, Anna; Ricard, Laure; Shah, Nimish; Liu, Qin; Zayac, Adam S.; Vassallo, Francesco; Lebras, Laure; Roulin, Louise; Lombion, Naelle; Manos, Kate; Fernandez, Ruben; Hamad, Nada; Lopez-Garcia, Alberto; O'Mahony, Deirdre; Gounder, Praveen; Forgeard, Nathalie; Lees, Charlotte; Agbetiafa, Kossi; Strüßmann, Tim; Htut, Thura Win; Clavert, Aline; Scott, Hamish; Guidetti, Anna; Barlow, Brett R.; Tchernonog, Emmanuelle; Smith, Jeffery; Miall, Fiona; Fox, Christopher P.; Cheah, Chan Y.; El Galaly, Tarec Christoffer; Ferreri, Andrés J. M.; Cwynarski, Kate; McKay, Pamela

doi:10.1182/blood.2021014506

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BACKGROUND: falls in care homes are common, costly and hard to prevent.Multifactorial falls programmes demonstrate clinical and cost-effectiveness, but the heterogeneity of the care home sector is a barrier to their implementation. A fuller appreciat... Read More about A realist evaluation of a multifactorial falls prevention programme in care homes.

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Background: Primary diffuse large B-cell lymphoma (DLBCL) of the central nervous system (PCNSL) is a rare disorder with an increasing incidence over the past decades. High-level evidence has been reported for the MATRix regimen (high-dose methotrexat... Read More about Optimizing MATRix as remission induction in PCNSL: de-escalated induction treatment in newly diagnosed primary CNS lymphoma.

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Timing of high-dose methotrexate CNS prophylaxis in DLBCL: a multicenter international analysis of 1384 patients (2022)
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Prophylactic high-dose methotrexate (HD-MTX) is often used for diffuse large B-cell lymphoma (DLBCL) patients at high risk of central nervous system (CNS) relapse, despite limited evidence demonstrating efficacy or the optimal delivery method. We con... Read More about Timing of high-dose methotrexate CNS prophylaxis in DLBCL: a multicenter international analysis of 1384 patients.

All Outputs (10)