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Rare central nervous system lymphomas


Furqaan Ahmed Kaji


Vishakha Sovani

Clinical Professor in Haematology


Central nervous system (CNS) lymphomas are rare malignancies characterised by lymphoid infiltration into the brain, spinal cord, cranial nerves, meninges and/or eyes in the presence or absence of previous or concurrent systemic disease. Most CNS lymphomas are of the diffuse large B-cell lymphoma (DLBCL) subtype for which treatment strategies, particularly the use of high-dose methotrexate-based protocols and consolidation with autologous stem cell transplantation, are well established. Other histopathological subtypes of CNS lymphoma are comparatively less common with published data on these rare lymphomas dominated by smaller case series and retrospective reports. Consequently, there exists little clinical consensus on the optimal methods to diagnose and manage these clinically and biologically heterogeneous CNS lymphomas. In this review article, we focus on rarer CNS lymphomas, summarising the available clinical data on incidence, context, diagnostic features, reported management strategies, and clinical outcomes.


Kaji, F. A., Martinez?Calle, N., Sovani, V., & Fox, C. P. (2022). Rare central nervous system lymphomas. British Journal of Haematology, 197(6), 662-678.

Journal Article Type Review
Acceptance Date Feb 23, 2022
Online Publication Date Mar 16, 2022
Publication Date 2022-06
Deposit Date Mar 22, 2022
Publicly Available Date Mar 22, 2022
Journal British Journal of Haematology
Print ISSN 0007-1048
Electronic ISSN 1365-2141
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 197
Issue 6
Pages 662-678
Keywords Hematology
Public URL
Publisher URL


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