N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells

Abakir, Abdulkadir; Giles, Tom C.; Cristini, Agnese; Foster, Jeremy M.; Dai, Nan; Starczak, Marta; Rubio-Roldan, Alejandro; Li, Miaomiao; Eleftheriou, Maria; Crutchley, James; Flatt, Luke; Young, Lorraine; Gaffney, Daniel J.; Denning, Chris; Dalhus, Bj�rn; Emes, Richard D.; Gackowski, Daniel; Corr�a, Ivan R.; Garcia-Perez, Jose L.; Klungland, Arne; Gromak, Natalia; Ruzov, Alexey

doi:10.1038/s41588-019-0549-x

All Outputs (3)

SnoRNAs in cardiovascular development, function, and disease (2024)
Journal Article
Chabronova, A., Holmes, T. L., Hoang, D. M., Denning, C., James, V., Smith, J. G. W., & Peffers, M. J. (2024). SnoRNAs in cardiovascular development, function, and disease. Trends in Molecular Medicine, https://doi.org/10.1016/j.molmed.2024.03.004

Small nucleolar RNAs (snoRNAs) are emerging as important regulators of cardiovascular (patho)biology. Several roles of snoRNAs have recently been identified in heart development and congenital heart diseases, as well as their dynamic regulation in hy... Read More about SnoRNAs in cardiovascular development, function, and disease.

Transcriptomic Analysis of Cardiomyocyte Extracellular Vesicles in Hypertrophic Cardiomyopathy Reveals Differential snoRNA Cargo (2021)
Journal Article
James, V., Nizamudeen, Z. A., Lea, D., Dottorini, T., Holmes, T. L., Johnson, B. B., …Smith, J. G. (2021). Transcriptomic Analysis of Cardiomyocyte Extracellular Vesicles in Hypertrophic Cardiomyopathy Reveals Differential snoRNA Cargo. Stem Cells and Development, 30(24), 1215-1227. https://doi.org/10.1089/scd.2021.0202

Hypertrophic cardiomyopathy (HCM) is characterised by increased left ventricular wall thickness that can lead to devastating conditions such as heart failure and sudden cardiac death. Despite extensive study, the mechanisms mediating many of the asso... Read More about Transcriptomic Analysis of Cardiomyocyte Extracellular Vesicles in Hypertrophic Cardiomyopathy Reveals Differential snoRNA Cargo.

N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells (2019)
Journal Article
Abakir, A., Giles, T. C., Cristini, A., Foster, J. M., Dai, N., Starczak, M., …Ruzov, A. (2020). N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells. Nature Genetics, 52(1), 48-55. https://doi.org/10.1038/s41588-019-0549-x

© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc. R-loops are nucleic acid structures formed by an RNA:DNA hybrid and unpaired single-stranded DNA that represent a source of genomic instability in mammalian cells1–4. Her... Read More about N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells.