All Outputs (2)

Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases (2024)
Journal Article
Shek, N., Choy, A., Lang, C. C., Miller, B. E., Tal-Singer, R., Bolton, C. E., …Huang, J. T. J. (2024). Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases. npj Aging, 10(1), Article 15. https://doi.org/10.1038/s41514-024-00143-7

Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and seve... Read More about Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases.

Accelerated immune ageing is associated with COVID-19 disease severity (2024)
Journal Article
Lord, J. M., Veenith, T., Sullivan, J., Sharma-Oates, A., Richter, A. G., Greening, N. J., …Bolton, C. E. (2024). Accelerated immune ageing is associated with COVID-19 disease severity. Immunity and Ageing, 21(1), Article 6. https://doi.org/10.1186/s12979-023-00406-z

Background: The striking increase in COVID-19 severity in older adults provides a clear example of immunesenescence, the age-related remodelling of the immune system. To better characterise the association between convalescent immunesenescence and ac... Read More about Accelerated immune ageing is associated with COVID-19 disease severity.