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All Outputs (46)

Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases (2024)
Journal Article
Shek, N., Choy, A., Lang, C. C., Miller, B. E., Tal-Singer, R., Bolton, C. E., …Huang, J. T. J. (2024). Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases. npj Aging, 10(1), Article 15. https://doi.org/10.1038/s41514-024-00143-7

Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and seve... Read More about Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases.

Accelerated immune ageing is associated with COVID-19 disease severity (2024)
Journal Article
Lord, J. M., Veenith, T., Sullivan, J., Sharma-Oates, A., Richter, A. G., Greening, N. J., …Bolton, C. E. (2024). Accelerated immune ageing is associated with COVID-19 disease severity. Immunity and Ageing, 21(1), Article 6. https://doi.org/10.1186/s12979-023-00406-z

Background: The striking increase in COVID-19 severity in older adults provides a clear example of immunesenescence, the age-related remodelling of the immune system. To better characterise the association between convalescent immunesenescence and ac... Read More about Accelerated immune ageing is associated with COVID-19 disease severity.

Balancing the value and risk of exercise-based therapy post-COVID-19: a narrative review (2023)
Journal Article
Singh, S. J., Daynes, E., McAuley, H. J., Raman, B., Greening, N. J., Chalder, T., …Bolton, C. E. (2023). Balancing the value and risk of exercise-based therapy post-COVID-19: a narrative review. European Respiratory Review, 32(170), Article 230110. https://doi.org/10.1183/16000617.0110-2023

Coronavirus disease 2019 (COVID-19) can lead to ongoing symptoms such as breathlessness, fatigue and muscle pain, which can have a substantial impact on an individual. Exercise-based rehabilitation programmes have proven beneficial in many long-term... Read More about Balancing the value and risk of exercise-based therapy post-COVID-19: a narrative review.

Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases (2023)
Preprint / Working Paper
Huang, J., Shek, N., Choy, A., Lang, C., Miller, B., Tal-Singer, R., …Brown, M. Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases

Aging is a major driving force for many diseases but the relationship between age, aging processes and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related... Read More about Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases.

Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19: the PHOSP-COVID analysis (2023)
Journal Article
Dawson, C., Clunie, G., Evison, F., Duncan, S., Whitney, J., Houchen-Wolloff, L., …PHOSP-COVID collaborative Group. (2023). Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19: the PHOSP-COVID analysis. BMJ Open Respiratory Research, 10(1), Article e001647. https://doi.org/10.1136/bmjresp-2023-001647

Objective: Identify prevalence of self-reported swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19. Design: Multicentre prospective observational cohort study using questionnaire data at visit 1 (2–7 mont... Read More about Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19: the PHOSP-COVID analysis.

Association between antidepressants with pneumonia and exacerbation in patients with COPD: a self-controlled case series (SCCS) (2023)
Journal Article
Siraj, R. A., Bolton, C. E., & McKeever, T. M. (2023). Association between antidepressants with pneumonia and exacerbation in patients with COPD: a self-controlled case series (SCCS). Thorax, 79(1), 50-57. https://doi.org/10.1136/thorax-2022-219736

Objective: To assess whether antidepressant prescriptions are associated with an increased risk of pneumonia and chronic obstructive pulmonary disease (COPD) exacerbation. Methods: A self-controlled case series was performed to investigate the rates... Read More about Association between antidepressants with pneumonia and exacerbation in patients with COPD: a self-controlled case series (SCCS).

Circulating testosterone levels and health outcomes in chronic obstructive pulmonary disease: results from ECLIPSE and ERICA (2023)
Journal Article
Pavey, H., Polkey, M. I., Bolton, C. E., Cheriyan, J., McEniery, C. M., Wilkinson, I., …Fisk, M. (2023). Circulating testosterone levels and health outcomes in chronic obstructive pulmonary disease: results from ECLIPSE and ERICA. BMJ Open Respiratory Research, 10(1), Article e001601. https://doi.org/10.1136/bmjresp-2022-001601

The relationship of circulating testosterone levels with health outcomes in people with chronic obstructive pulmonary disease (COPD) is unknown. Aim To determine whether serum testosterone levels predict hospitalised acute exacerbations of COPD... Read More about Circulating testosterone levels and health outcomes in chronic obstructive pulmonary disease: results from ECLIPSE and ERICA.

Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID) (2023)
Preprint / Working Paper
Elneima, O., McAuley, H. J. C., Leavy, O. C., Chalmers, J. D., Horsley, A., Ho, L., …on behalf of the PHOSP-COVID Collaborative Group. Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID)

PHOSP-COVID is a national UK multi-centre cohort study of patients who were hospitalised for COVID-19 and subsequently discharged. PHOSP-COVID was established to investigate the medium- and long-term sequelae of severe COVID-19 requiring hospitali... Read More about Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID).

Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study (2023)
Journal Article
Jackson, C., Stewart, I. D., Plekhanova, T., Cunningham, P. S., Hazel, A. L., Al-Sheklly, B., …Blaikley, J. F. (2023). Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study. Lancet Respiratory Medicine, 11(8), 673-684. https://doi.org/10.1016/S2213-2600%2823%2900124-8

Sleep disturbance is common following hospital admission both for COVID-19 and other causes. The clinical associations of this for recovery after hospital admission are poorly understood despite sleep disturbance contributing to morbidity in other sc... Read More about Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study.

Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study (2023)
Journal Article
McAuley, H. J., Evans, R. A., Bolton, C. E., Brightling, C. E., Chalmers, J. D., Docherty, A. B., …Greening, N. J. (2023). Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study. eClinicalMedicine, 57, Article 101896. https://doi.org/10.1016/j.eclinm.2023.101896

Background: The scale of COVID-19 and its well documented long-term sequelae support a need to understand long-term outcomes including frailty. Methods: This prospective cohort study recruited adults who had survived hospitalisation with clinically d... Read More about Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study.

Device-assessed sleep and physical activity in individuals recovering from a hospital admission for COVID-19: a multicentre study (2022)
Journal Article
Plekhanova, T., Rowlands, A. V., Evans, R. A., Edwardson, C. L., Bishop, N. C., Bolton, C. E., …PHOSP-COVID Collaborative Group. (2022). Device-assessed sleep and physical activity in individuals recovering from a hospital admission for COVID-19: a multicentre study. International Journal of Behavioral Nutrition and Physical Activity, 19(1), Article 94. https://doi.org/10.1186/s12966-022-01333-w

Background: The number of individuals recovering from severe COVID-19 is increasing rapidly. However, little is known about physical behaviours that make up the 24-h cycle within these individuals. This study aimed to describe physical behaviours fol... Read More about Device-assessed sleep and physical activity in individuals recovering from a hospital admission for COVID-19: a multicentre study.

Impact of Coexisting Dementia on Inpatient Outcomes for Patients Admitted with a COPD Exacerbation (2022)
Journal Article
Gupta, A., McKeever, T. M., Hutchinson, J. P., & Bolton, C. E. (2022). Impact of Coexisting Dementia on Inpatient Outcomes for Patients Admitted with a COPD Exacerbation. International Journal of Chronic Obstructive Pulmonary Disease, 2022(17), 535-544. https://doi.org/10.2147/copd.s345751

Purpose: People with COPD are at a higher risk of cognitive dysfunction than the general population. However, the additional impact of dementia amongst such patients is not well understood, particularly in those admitted with a COPD exacerbation. We... Read More about Impact of Coexisting Dementia on Inpatient Outcomes for Patients Admitted with a COPD Exacerbation.

Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19 (2022)
Journal Article
Houchen-Wolloff, L., Poinasamy, K., Holmes, K., Tarpey, M., Hastie, C., Raihani, K., …Evans, R. A. (2022). Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19. Thorax, 77(7), 717-720. https://doi.org/10.1136/thoraxjnl-2021-218582

Given the large numbers of people infected and high rates of ongoing morbidity, research is clearly required to address the needs of adult survivors of COVID-19 living with ongoing symptoms (long COVID). To help direct resource and research efforts,... Read More about Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19.

Whole-body and muscle responses to aerobic exercise training and withdrawal in ageing and COPD (2021)
Journal Article
Latimer, L. E., Constantin-Teodosiu, D., Popat, B., Constantin, D., Houchen-Wolloff, L., Bolton, C. E., …Greenhaff, P. L. (2022). Whole-body and muscle responses to aerobic exercise training and withdrawal in ageing and COPD. European Respiratory Journal, 59(5), Article 2101507. https://doi.org/10.1183/13993003.01507-2021

BACKGROUND: Chronic obstructive pulmonary disease (COPD) patients exhibit lower peak oxygen uptake (V'O2peak), altered muscle metabolism and impaired exercise tolerance compared with age-matched controls. Whether these traits reflect muscle-level dec... Read More about Whole-body and muscle responses to aerobic exercise training and withdrawal in ageing and COPD.

Developing good practice by understanding how UK medical schools address low level concerns: a survey study (2021)
Journal Article
Vivekananda-Schmidt, P., Bolton, C., & Knox, R. (2022). Developing good practice by understanding how UK medical schools address low level concerns: a survey study. Education for Primary Care, 33(1), 6-12. https://doi.org/10.1080/14739879.2021.1948805

In the literature, a distinction is made between low-level concerns and what is regarded as fitness to practise concerns. The General Medical Council expects all UK medical schools to have a transparent process in place about how concerns about its m... Read More about Developing good practice by understanding how UK medical schools address low level concerns: a survey study.

Improving lung health in low-income and middle-income countries: from challenges to solutions (2021)
Journal Article
Meghji, J., Mortimer, K., Agusti, A., Allwood, B. W., Asher, I., Bateman, E. D., …Marks, G. B. (2021). Improving lung health in low-income and middle-income countries: from challenges to solutions. Lancet, 397(10277), 928-940. https://doi.org/10.1016/S0140-6736%2821%2900458-X

Low-income and middle-income countries (LMICs) bear a disproportionately high burden of the global morbidity and mortality caused by chronic respiratory diseases (CRDs), including asthma, chronic obstructive pulmonary disease, bronchiectasis, and pos... Read More about Improving lung health in low-income and middle-income countries: from challenges to solutions.

The feasibility and tolerability of using Inspiratory Muscle Training (IMT) with adults discharged from the hospital with community-acquired pneumonia (CAP) (2021)
Journal Article
Pick, H., Faghy, M., Cresswell, G., Ashton, D., Bolton, C., McKeever, T., …Bewick, T. (2021). The feasibility and tolerability of using Inspiratory Muscle Training (IMT) with adults discharged from the hospital with community-acquired pneumonia (CAP). Advances in Respiratory Medicine, 89, 216-220. https://doi.org/10.5603/ARM.a2021.0002

Background: Patients experience substantial morbidity following discharge from hospital and during recovery from community-acquired pneumonia (CAP). Inspiratory muscle training (IMT) has demonstrated improved functional capacity and reduced patient-r... Read More about The feasibility and tolerability of using Inspiratory Muscle Training (IMT) with adults discharged from the hospital with community-acquired pneumonia (CAP).

Cardiovascular risk prediction using physical performance measures in COPD: results from a multicentre observational study (2020)
Journal Article
Fermont, J. M., Fisk, M., Bolton, C. E., MacNee, W., Cockcroft, J. R., Fuld, J., …Wilkinson, I. B. (2020). Cardiovascular risk prediction using physical performance measures in COPD: results from a multicentre observational study. BMJ Open, 10(12), Article e038360. https://doi.org/10.1136/bmjopen-2020-038360

Objectives Although cardiovascular disease (CVD) is a common comorbidity associated with chronic obstructive pulmonary disease (COPD), it is unknown how to improve prediction of cardiovascular (CV) risk in individuals with COPD. Traditional CV risk s... Read More about Cardiovascular risk prediction using physical performance measures in COPD: results from a multicentre observational study.