Rapid nano-gram scale screening method of micro-arrays to evaluate drug-polymer blends using high-throughput printing technology

Taresco, Vincenzo; Louzao, Iria; Scurr, David J.; Turpin, Eleanor R.; Laughton, Charles A.; Alexander, Cameron; Burley, Jonathan C.; Garnett, Martin

doi:10.1021/acs.molpharmaceut.7b00182

All Outputs (4)

Development of a series of bis-triazoles as G-quadruplex ligands (2017)
Journal Article

Maintenance of telomeres – specialized complexes that protect the ends of chromosomes – is provided by the enzyme complex telomerase, which is a key factor that is activated in more than 80% of cancer cells, but absent in most normal cells. Targeting... Read More about Development of a series of bis-triazoles as G-quadruplex ligands.

Covariance analysis for temporal data, with applications to DNA modelling (2017)
Journal Article

We introduce methodology for analysing the mean size-and-shape and covariance matrix of landmark data that are collected over time. Motivated by a study of DNA damage, we study some permutation based tests for investigating significant differences in... Read More about Covariance analysis for temporal data, with applications to DNA modelling.

Unveiling a novel transient druggable pocket in BACE-1 through molecular simulations: conformational analysis and binding mode of multisite inhibitors (2017)
Journal Article

The critical role of BACE-1 in the formation of neurotoxic ß-amyloid peptides in the brain makes it an attractive target for an efficacious treatment of Alzheimer’s disease. However, the development of clinically useful BACE-1 inhibitors has proven t... Read More about Unveiling a novel transient druggable pocket in BACE-1 through molecular simulations: conformational analysis and binding mode of multisite inhibitors.

Rapid nano-gram scale screening method of micro-arrays to evaluate drug-polymer blends using high-throughput printing technology (2017)
Journal Article

A miniaturized, high-throughput assay was optimized to screen polymer-drug solid dispersions using a 2-D Ink-jet printer. By simply printing nanoliter amounts of polymer and drug solutions onto an inert surface, drug:polymer micro-dots of tunable com... Read More about Rapid nano-gram scale screening method of micro-arrays to evaluate drug-polymer blends using high-throughput printing technology.