Communication of prostate cancer cells with bone cells via extracellular vesicle RNA; a potential mechanism of metastasis

Probert, C.; Dottorini, T.; Speakman, A.; Hunt, S.; Nafee, T.; Fazeli, A.; Wood, S.; Brown, J. E.; James, V.

doi:10.1038/s41388-018-0540-5

All Outputs (3)

Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts (2023)
Journal Article

Purpose This 3D in vitro cancer model for propagation of patient-derived cells, using a synthetic self-assembling peptide gel, allows the formation of a fully characterised, tailorable tumour microenvironment. Unlike many existing 3D cancer models,... Read More about Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts.

A 3D Heterotypic Breast Cancer Model Demonstrates a Role for Mesenchymal Stem Cells in Driving a Proliferative and Invasive Phenotype (2020)
Journal Article

Communication of prostate cancer cells with bone cells via extracellular vesicle RNA; a potential mechanism of metastasis (2018)
Journal Article

© 2018, The Author(s). The role of extracellular vesicles (EVs) as vehicles for cell-to-cell communication between a tumour and its environment is a relatively new concept. The hypothesis that EVs may be critical in co-opting tissues by tumours to ge... Read More about Communication of prostate cancer cells with bone cells via extracellular vesicle RNA; a potential mechanism of metastasis.