All Outputs (12)

A conserved trypanosomatid differentiation regulator controls substrate attachment and morphological development in Trypanosoma congolense (2024)
Journal Article

Trypanosomatid parasites undergo developmental regulation to adapt to the different environments encountered during their life cycle. In Trypanosoma brucei, a genome wide selectional screen previously identified a regulator of the protein family ESAG... Read More about A conserved trypanosomatid differentiation regulator controls substrate attachment and morphological development in Trypanosoma congolense.

A transferrin receptor’s guide to African trypanosomes (2023)
Journal Article

Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition (2021)
Journal Article

Animal African Trypanosomiasis (AAT) is a debilitating livestock disease prevalent across sub-Saharan Africa, a main cause of which is the protozoan parasite Trypanosoma congolense. In comparison to the well-studied T. brucei, there is a major paucit... Read More about Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition.

Reliable, scalable functional genetics in bloodstream-form Trypanosoma congolense in vitro and in vivo (2021)
Journal Article

Copyright: © 2021 Awuah-Mensah et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author a... Read More about Reliable, scalable functional genetics in bloodstream-form Trypanosoma congolense in vitro and in vivo.

Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes (2020)
Journal Article

© 2020 Zoltner et al. Introduced about a century ago, suramin remains a frontline drug for the management of early-stage East African trypanosomiasis (sleeping sickness). Cellular entry into the causative agent, the protozoan parasite Trypanosoma bru... Read More about Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes.

Technical challenges of working with extracellular vesicles (2017)
Journal Article

© 2018 The Royal Society of Chemistry. Extracellular Vesicles (EVs) are gaining interest as central players in liquid biopsies, with potential applications in diagnosis, prognosis and therapeutic guidance in most pathological conditions. These nanosi... Read More about Technical challenges of working with extracellular vesicles.

Lineage-specific proteins essential for endocytosis in trypanosomes (2017)
Journal Article

Clathrin-mediated endocytosis (CME) is the most evolutionarily ancient endocytic mechanism known, and in many lineages the sole mechanism for internalisation. Significantly, in mammalian cells CME is responsible for the vast bulk of endocytic flux an... Read More about Lineage-specific proteins essential for endocytosis in trypanosomes.

The Trypanosome Exocyst: A Conserved Structure Revealing a New Role in Endocytosis (2017)
Journal Article

© 2017 Boehm et al. Membrane transport is an essential component of pathogenesis for most infectious organisms. In African trypanosomes, transport to and from the plasma membrane is closely coupled to immune evasion and antigenic variation. In mammal... Read More about The Trypanosome Exocyst: A Conserved Structure Revealing a New Role in Endocytosis.

ENTH and ANTH domain proteins participate in AP2-independent clathrin-mediated endocytosis (2015)
Journal Article

Clathrin-mediated endocytosis (CME) is a major route of entry into eukaryotic cells. A core of evolutionarily ancient genes encodes many components of this system but much of our mechanistic understanding of CME is derived from a phylogenetically nar... Read More about ENTH and ANTH domain proteins participate in AP2-independent clathrin-mediated endocytosis.

Architecture of a host–parasite interface: complex targeting mechanisms revealed through proteomics (2015)
Journal Article

Surface membrane organization and composition is key to cellular function, and membrane proteins serve many essential roles in endocytosis, secretion, and cell recognition. The surface of parasitic organisms, however, is a double-edged sword; this is... Read More about Architecture of a host–parasite interface: complex targeting mechanisms revealed through proteomics.

Specificity and Function of Archaeal DNA Replication Initiator Proteins (2013)
Journal Article

Chromosomes with multiple DNA replication origins are a hallmark of Eukaryotes and some Archaea. All eukaryal nuclear replication origins are defined by the origin recognition complex (ORC) that recruits the replicative helicase MCM(2-7) via Cdc6 and... Read More about Specificity and Function of Archaeal DNA Replication Initiator Proteins.

Proteomic Analysis of Clathrin Interactions in Trypanosomes Reveals Dynamic Evolution of Endocytosis (2013)
Journal Article

Endocytosis is a vital cellular process maintaining the cell surface, modulating signal transduction and facilitating nutrient acquisition. In metazoa, multiple endocytic modes are recognized, but for many unicellular organisms the process is likely... Read More about Proteomic Analysis of Clathrin Interactions in Trypanosomes Reveals Dynamic Evolution of Endocytosis.