All Outputs (6)

Quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 T: A feasibility study (2021)
Journal Article
Alyami, A., Hoad, C. L., Tench, C., Bannur, U., Clarke, C., Latief, K., …Moran, G. W. (2021). Quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 T: A feasibility study. Diagnostics, 11(11), Article 2135. https://doi.org/10.3390/diagnostics11112135

Perianal Crohn’s Disease (pCD) is a common manifestation of Crohn’s Disease. Absence of reliable disease measures makes disease monitoring unreliable. Qualitative MRI has been increasingly used for diagnosing and monitoring pCD and has shown potentia... Read More about Quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 T: A feasibility study.

Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies (2021)
Journal Article
Dellschaft, N., Hoad, C., Marciani, L., Gowland, P., & Spiller, R. (2022). Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies. Alimentary Pharmacology and Therapeutics, 55(3), 327-338. https://doi.org/10.1111/apt.16673

Background: New developments in MRI have allowed the non-invasive, accurate measurement of the small bowel water content (SBWC). Aims: To collate studies measuring SBWC following ingestion of a range of foods in both health and disease to provide dat... Read More about Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies.

Luminal fluid motion inside an in vitro dissolution model of the human ascending colon assessed using magnetic resonance imaging (2021)
Journal Article
O’Farrell, C., Hoad, C. L., Stamatopoulos, K., Marciani, L., Sulaiman, S., Simmons, M. J. H., & Batchelor, H. K. (2021). Luminal fluid motion inside an in vitro dissolution model of the human ascending colon assessed using magnetic resonance imaging. Pharmaceutics, 13(10), Article 1545. https://doi.org/10.3390/pharmaceutics13101545

Knowledge of luminal flow inside the human colon remains elusive, despite its importance for the design of new colon-targeted drug delivery systems and physiologically relevant in silico models of dissolution mechanics within the colon. This study us... Read More about Luminal fluid motion inside an in vitro dissolution model of the human ascending colon assessed using magnetic resonance imaging.

Psyllium reduces insulin-induced colonic gas production in irritable bowel syndrome: MRI and in vitro fermentation studies (2021)
Journal Article
Gunn, D., Abbas, Z., Harris, H., Major, G., Hoad, C., Gowland, P., …Spiller, R. (2022). Psyllium reduces insulin-induced colonic gas production in irritable bowel syndrome: MRI and in vitro fermentation studies. Gut, 71(5), 919-927. https://doi.org/10.1136/gutjnl-2021-324784

Objective: Health promoting dietary fibre including inulin often triggers gastrointestinal symptoms in patients with irritable bowel syndrome (IBS), limiting their intake. Our aim was to test if co-administering psyllium with inulin would reduce gas... Read More about Psyllium reduces insulin-induced colonic gas production in irritable bowel syndrome: MRI and in vitro fermentation studies.

Test–retest assessment of non-contrast MRI sequences to characterise and quantify the small bowel wall in healthy participants (2021)
Journal Article
Alyami, A. S., Williams, H. G., Argyriou, K., Gunn, D., Wilkinson-Smith, V., White, J. R., …Hoad, C. L. (2021). Test–retest assessment of non-contrast MRI sequences to characterise and quantify the small bowel wall in healthy participants. Magnetic Resonance Materials in Physics, Biology and Medicine, 34, 791-804. https://doi.org/10.1007/s10334-021-00931-2

Objective: Quantitative Magnetic Resonance Imaging sequences have been investigated as objective imaging biomarkers of fibrosis and inflammation in Crohn’s disease. Aim: To determine the repeatability and inter- and intra-observer agreement of these... Read More about Test–retest assessment of non-contrast MRI sequences to characterise and quantify the small bowel wall in healthy participants.

Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI (2021)
Journal Article
Sharif, H., Hoad, C. L., Abrehart, N., Gowland, P. A., Spiller, R. C., Kirkham, S., …Marciani, L. (2021). Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI. Diagnostics, 11(6), Article 974. https://doi.org/10.3390/diagnostics11060974

Background: Functional constipation in children is common. Management of this condition can be challenging and is often based on symptom reports. Increased, objective knowledge of colonic volume changes in constipation compared to health could provid... Read More about Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI.