All Outputs (140)

Development and validation of risk prediction equations to estimate survival in patients with colorectal cancer: cohort study (2017)
Journal Article

Objective: To develop and externally validate risk prediction equations to estimate absolute and conditional survival in patients with colorectal cancer. Design: Cohort study. Setting: General practices in England providing data for the QResea... Read More about Development and validation of risk prediction equations to estimate survival in patients with colorectal cancer: cohort study.

Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study (2017)
Journal Article

Objectives: To develop and validate updated QRISK3 prediction algorithms to estimate the 10 year risk of cardiovascular disease in women and men accounting for potential new risk factors. Design: Prospective open cohort study. Setting: General... Read More about Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study.

Concerns on 'clinical features of bowel disease paper in patients (eLetter) (2017)
Journal Article

Evaluating implementation of a fire-prevention injury prevention briefing in children's centres: cluster randomised controlled trial (2017)
Journal Article

Background: Many developed countries have high mortality rates for fire-related deaths in children aged 0–14 years with steep social gradients. Evidence-based interventions to promote fire safety practices exist, but the impact of implementing a rang... Read More about Evaluating implementation of a fire-prevention injury prevention briefing in children's centres: cluster randomised controlled trial.

Use of conspicuity aids by cyclists and risk of crashes involving other road users: population based case-control study (2017)
Journal Article

Background: Cycling can improve health and well-being by reducing inactivity. Concern about collision crashes may be a barrier to participation since collision crashes can lead to significant mortality and morbidity. The conspicuity of cyclists may b... Read More about Use of conspicuity aids by cyclists and risk of crashes involving other road users: population based case-control study.

Poison prevention practices and medically attended poisoning in young children: multicentre case-control study (2016)
Journal Article

Introduction Childhood poisonings are common, placing a substantial burden on health services. Case-control studies have found inconsistent evidence about modifiable risk factors for poisonings amongst 0-4 year olds. This study quantifies associat... Read More about Poison prevention practices and medically attended poisoning in young children: multicentre case-control study.

The impact of psychological factors on recovery from injury: a multicentre cohort study (2016)
Journal Article

Purpose Unintentional injuries have a significant long-term health impact in working age adults. Depression, anxiety and post-traumatic stress disorder are common post-injury, but their impact on self-reported recovery has not been investigated in g... Read More about The impact of psychological factors on recovery from injury: a multicentre cohort study.

Psychological morbidity and health related quality of life after injury: multicentre cohort study (2016)
Journal Article

Purpose: To demonstrate the impact of psychological morbidity one month post-injury on subsequent post-injury quality of life (HRQoL) in a general injury population in the UK to inform development of trauma care and rehabilitation services. Method... Read More about Psychological morbidity and health related quality of life after injury: multicentre cohort study.

Modifiable risk factors for scald injury in children under 5 years of age: a multi-centre case–control study (2016)
Journal Article

Objective: To determine the relationship between a range of modifiable risk factors and medically attended scalds in children under the age of 5 years. Methods: Multicentre matched case-control study in acute hospitals, minor injury units and GP pr... Read More about Modifiable risk factors for scald injury in children under 5 years of age: a multi-centre case–control study.

Diabetes treatments and risk of heart failure, cardiovascular disease and all-cause mortality: cohort study in primary care (2016)
Journal Article

Objective: To assess associations between risks of cardiovascular disease, heart failure, and all cause mortality and different diabetes drugs in people with type 2 diabetes, particularly newer agents, including gliptins and thiazolidinediones (glita... Read More about Diabetes treatments and risk of heart failure, cardiovascular disease and all-cause mortality: cohort study in primary care.

Discontinuation and restarting in patients on statin therapy: a cohort study using a primary care database (2016)
Journal Article

Objectives: To estimate rates of discontinuation and restarting of statins, and to identify patient characteristics associated with either discontinuation or restarting. Design: Prospective open cohort study. Setting: 664 general practices con... Read More about Discontinuation and restarting in patients on statin therapy: a cohort study using a primary care database.

Diabetes treatments and risk of amputation, blindness, severe kidney failure, hyperglycaemia, and hypoglycaemia: open cohort study in primary care (2016)
Journal Article

Objective: To assess the risks of amputation, blindness, severe kidney failure, hyperglycaemia, and hypoglycaemia in patients with type 2 diabetes associated with prescribed diabetes drugs, particularly newer agents including gliptins or glitazones (... Read More about Diabetes treatments and risk of amputation, blindness, severe kidney failure, hyperglycaemia, and hypoglycaemia: open cohort study in primary care.

Antidepressant use and risk of cardiovascular outcomes in people aged 20 to 64: Cohort study using primary care database (2016)
Journal Article

© BMJ Publishing Group Ltd 2016. Objective To assess associations between different antidepressant treatments and rates of three cardiovascular outcomes (myocardial infarction, stroke or transient ischaemic attack, and arrhythmia) in people with depr... Read More about Antidepressant use and risk of cardiovascular outcomes in people aged 20 to 64: Cohort study using primary care database.

Missed opportunities to keep children safe? National survey of injury prevention activities of children’s centres (2016)
Journal Article

Objective: To ascertain the activities undertaken by children’s centres to prevent unintentional injuries in the under-fives and, in particular, the prevention of falls, poisoning and scalds. Design: A questionnaire was posted to managers of 851 chi... Read More about Missed opportunities to keep children safe? National survey of injury prevention activities of children’s centres.

The NHS Health Check in England: an evaluation of the first 4?years (2016)
Journal Article

Objectives: To describe implementation of a new national preventive programme to reduce cardiovascular morbidity. Design: Observational study over 4 years (April 2009—March 2013). Setting: 655 general practices across England from the QResear... Read More about The NHS Health Check in England: an evaluation of the first 4?years.

Antidepressant use and risk of epilepsy and seizures in people aged 20 to 64 years: cohort study using a primary care database (2015)
Journal Article

Background: Epilepsy is a serious condition which can profoundly affect an individual’s life. While there is some evidence to suggest an association between antidepressant use and epilepsy and seizures it is conflicting and not conclusive. Antidepres... Read More about Antidepressant use and risk of epilepsy and seizures in people aged 20 to 64 years: cohort study using a primary care database.

Cycling infrastructure for reducing cycling injuries in cyclists (2015)
Journal Article

Background: Cycling is an attractive form of transport. It is beneficial to the individual as a form of physical activity that may fit more readily into an individual’s daily routine, such as for cycling to work and to the shops, than other physical... Read More about Cycling infrastructure for reducing cycling injuries in cyclists.

Risk and protective factors for falls on stairs in young children: multicentre case–control study (2015)
Journal Article

Aim: To investigate risk and protective factors for stair falls in children aged

Risk and protective factors for falls on one level in young children: multicentre case-control study (2015)
Journal Article

Background: Childhood falls are an important global public health problem, but there is a lack of evidence about their prevention. Falls on one level result in considerable morbidity and they are costly to health services. Objective: To estimate o... Read More about Risk and protective factors for falls on one level in young children: multicentre case-control study.

Development and validation of risk prediction equations to estimate future risk of blindness and lower limb amputation in patients with diabetes: cohort study (2015)
Journal Article

Study question: Is it possible to develop and externally validate risk prediction equations to estimate the 10 year risk of blindness and lower limb amputation in patients with diabetes aged 25-84 years? Methods: This was a prospective cohort stud... Read More about Development and validation of risk prediction equations to estimate future risk of blindness and lower limb amputation in patients with diabetes: cohort study.