All Outputs (129)

Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting (2021)
Journal Article

OBJECTIVE: To determine the burden of comorbidities in OA and their temporal relationships in the UK. METHODS: The Clinical Practice Research Datalink (CPRD) GOLD was used to identify people with incident OA and age, gender and practice matched n... Read More about Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting.

Hormone replacement therapy and dementia risk: nested case-control studies using CPRD and QResearch (2021)
Journal Article

Introduction: Research from clinical trials of hormone replacement therapy (HRT) has produced conflicting findings about possible risks of dementia after receiving these treatments, and further research on HRT and dementia risk has been identified as... Read More about Hormone replacement therapy and dementia risk: nested case-control studies using CPRD and QResearch.

‘Real world’ effectiveness of the Falls Management Exercise (FaME) programme: an implementation study (2021)
Journal Article

Background Falls incidence increases with age alongside declines in strength and balance. Clinical trials show that the Falls Management Exercise (FaME) programme improves strength and balance, which can reduce falls and improve physical functioning... Read More about ‘Real world’ effectiveness of the Falls Management Exercise (FaME) programme: an implementation study.

Prostate-specific antigen testing and opportunistic prostate cancer screening: a cohort study in England, 1998–2017 (2021)
Journal Article

Background: Prostate cancer is a leading cause of cancer-related death. Interpretation of results from trials of screening with prostate-specific antigen (PSA) are complex in terms of defining optimal prostate cancer screening policy. Aims: Assess... Read More about Prostate-specific antigen testing and opportunistic prostate cancer screening: a cohort study in England, 1998–2017.

Development and validation of a novel algorithm to estimate risk of developing prostate cancer in asymptomatic men: a cohort study (2020)
Journal Article

Abstract Objective: To develop and validate a risk prediction equation to predict absolute risk of prostate cancer in asymptomatic men with prostate specific antigen (PSA) tests in primary care. Design: Open cohort study. Setting: Routine data from 1... Read More about Development and validation of a novel algorithm to estimate risk of developing prostate cancer in asymptomatic men: a cohort study.

Young people, mental health and COVID-19 infection: The canaries we put in the coal-mine (2020)
Journal Article

Background: The number of people testing positive for SARS-COV-2 in the UK, particularly among young adults, is increasing. We report here on the mental health of young adults and related psychological and behavioural responses to the pandemic, and c... Read More about Young people, mental health and COVID-19 infection: The canaries we put in the coal-mine.

Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases (2020)
Journal Article

Objective: To assess breast cancer risks associated with different types and durations of hormone replacement therapy Design: Two nested case-control studies Setting: UK general practices contributing to QResearch or Clinical Practice Research... Read More about Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases.

Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study (2020)
Journal Article

Objective: To derive and validate a risk prediction algorithm to estimate hospital admission and mortality outcomes from coronavirus disease 2019 (covid-19) in adults. Design: Population based cohort study. Setting and participants: QResearch d... Read More about Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study.

Evaluation of the effectiveness, implementation and cost-effectiveness of the Stay One Step Ahead home safety promotion intervention for pre-school children: a study protocol (2020)
Journal Article

Background: Unintentional injuries in children under the age of 5 years commonly occur in the home and disproportionately affect those living in disadvantaged circumstances. Targeted home safety promotion should be offered to families most at risk bu... Read More about Evaluation of the effectiveness, implementation and cost-effectiveness of the Stay One Step Ahead home safety promotion intervention for pre-school children: a study protocol.

Mental health in the UK during the COVID-19 pandemic: cross-sectional analyses from a community cohort study (2020)
Journal Article

Objectives: Previous pandemics have resulted in significant consequences for mental health. Here, we report the mental health sequelae of the COVID-19 pandemic in a UK cohort and examine modifiable and non-modifiable explanatory factors associated wi... Read More about Mental health in the UK during the COVID-19 pandemic: cross-sectional analyses from a community cohort study.

Risk of severe COVID-19 disease with ACE inhibitors and angiotensin receptor blockers: cohort study including 8.3 million people (2020)
Journal Article

Background: There is uncertainty about the associations of angiotensive enzyme (ACE) inhibitor and angiotensin receptor blocker (ARB) drugs with COVID-19 disease. We studied whether patients prescribed these drugs had altered risks of contracting sev... Read More about Risk of severe COVID-19 disease with ACE inhibitors and angiotensin receptor blockers: cohort study including 8.3 million people.

The MRI colonic function test: Reproducibility of the Macrogol stimulus challenge (2020)
Journal Article

Background Magnetic resonance imaging (MRI) of the colonic response to a macrogol challenge drink can be used to assess the mechanisms underlying severe constipation. We measured the intra-subject reproducibility of MRI measures of colonic funct... Read More about The MRI colonic function test: Reproducibility of the Macrogol stimulus challenge.

Incidence and prevalence of primary care antidepressant prescribing in children and young people in England, 1998-2017: A population-based cohort study (2020)
Journal Article

BACKGROUND: The use of antidepressants in children and adolescents remains controversial. We examined trends over time and variation in antidepressant prescribing in children and young people in England and whether the drugs prescribed reflected UK l... Read More about Incidence and prevalence of primary care antidepressant prescribing in children and young people in England, 1998-2017: A population-based cohort study.

Real-world effect of antidepressants for depressive disorder in primary care: protocol of a population-based cohort study (2020)
Journal Article

Introduction: Clinical guidelines recommend antidepressants as the first line of treatment for adults with moderate-to-severe depression. Randomised trials provide the best evidence on the comparative effectiveness of antidepressants for depression,... Read More about Real-world effect of antidepressants for depressive disorder in primary care: protocol of a population-based cohort study.

Comorbidities in Osteoarthritis: a systematic review and meta-analysis of observational studies (2020)
Journal Article

Objectives Osteoarthritis (OA) is a common chronic condition in older people but its association with other chronic conditions is largely unknown. This study aimed to systematically review the literature on comorbidities in people with OA compared... Read More about Comorbidities in Osteoarthritis: a systematic review and meta-analysis of observational studies.

Secondary care specialist visits made by children and young people prescribed antidepressants in primary care: A descriptive study using the QResearch database (2020)
Journal Article

© 2020 The Author(s). Background: Antidepressants may be used to manage a number of conditions in children and young people including depression, anxiety, and obsessive-compulsive disorder. UK guidelines for the treatment of depression in children an... Read More about Secondary care specialist visits made by children and young people prescribed antidepressants in primary care: A descriptive study using the QResearch database.

Trends in incidence and prevalence of osteoarthritis in the United Kingdom: findings from the Clinical Practice Research Datalink (CPRD) (2020)
Journal Article

© 2020 The Authors Objective: This study aimed to explore the incidence and prevalence of OA in the UK in 2017 and their trends from 1997 to 2017 using a large nationally representative primary care database. Design: The UK Clinical Practice Research... Read More about Trends in incidence and prevalence of osteoarthritis in the United Kingdom: findings from the Clinical Practice Research Datalink (CPRD).

Editorial Comment: Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control (2020)
Journal Article

Re: Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case Control Study (2019)
Journal Article

Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets (2019)
Journal Article

Introduction Increasing numbers of children and young people (CYP) are receiving prescriptions for antidepressants. This is the protocol of a study aiming to describe the trends and variation in antidepressant prescriptions in CYP in England, and t... Read More about Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets.